ABSTRACT
The study shows the development and optimization of locust bean gum (LBG)-alginate mucoadhesive macromolecules containing aceclofenac through ionotropic-gelation using 3(2) factorial design. The effect of amount of LBG and sodium alginate on drug entrapment efficiency (%DEE), % mucoadhesion at 8h (M8) and % in vitro drug release at 10h (%Q10h) were optimized. The percentage yield, average size and DEE of macromolecules were found within the range of 93.19 to 96.65%, 1.328 ± 0.11 to 1.428 ± 0.13 µm, and 56.37 to 68.54%, respectively. The macromolecules were also characterized by SEM, FTIR and DSC. The in vitro drug release from these macromolecules (84.95 ± 2.02 to 95.33 ± 1.56% at 10h) exhibited sustained release (first-order) pattern with super case-II transport mechanism. The swelling and mucoadhesivity of these macromolecules were affected by pH of the medium. The design established the role of derived polynomial equations and plots in predicting the values of dependent variables for the preparation and optimization.
Subject(s)
Alginates/chemistry , Diclofenac/analogs & derivatives , Drug Carriers/chemistry , Galactans/chemistry , Mannans/chemistry , Plant Gums/chemistry , Adhesiveness , Delayed-Action Preparations , Diclofenac/administration & dosage , Glucuronic Acid/chemistry , Hexuronic Acids/chemistryABSTRACT
Polysaccharides have been finding, in the last decades, very interesting and useful applications in the biomedical and, specifically, in the biopharmaceutical field. Galactomannans are a group of storage polysaccharides from various plant seeds that reserve energy for germination in the endosperm. There are four major sources of seed galactomannans: locust bean (Ceratonia siliqua), guar (Cyamopsis tetragonoloba), tara (Caesalpinia spinosa Kuntze), and fenugreek (Trigonella foenum-graecum L.). Through keen references of reported literature on galactomannans, in this review, we have described occurrence of various galactomannans, its physicochemical properties, characterization, applications, and overview of some major galactomannans.
Subject(s)
Mannans/chemistry , Galactose/analogs & derivatives , Hydrogen Bonding , Molecular Structure , Plant Gums , Polysaccharides/chemistry , Seeds/chemistry , ViscosityABSTRACT
Biopolymers or natural polymers are an attractive class of biodegradable polymers since they are derived from natural sources, easily available, relatively cheap and can be modified by suitable reagent. Locust bean gum is one of them that have a wide potentiality in drug formulations due to its extensive application as food additive and its recognized lack of toxicity. It can be tailored to suit its demands of applicants in both the pharmaceutical and biomedical areas. Locust bean gum has a wide application either in the field of novel drug delivery system as rate controlling excipients or in tissue engineering as scaffold formation. Through keen references of reported literature on locust bean gum, in this review, we have described critical aspects of locust bean gum, its manufacturing process, physicochemical properties and applications in various drug delivery systems.
