An unusual six-co-ordinate platinum(II) complex containing a neutral I2 ligand.

The present paper deals with a rare platinum(II) complex containing the kappa-I2 ligand, which is an unusual example of a six-co-ordinated octahedral platinum(II) complex.

Sexual transmission and reinfection of group B streptococci between spouses.

OBJECTIVE: To study how GBS infection takes place between pregnant GBS-carriers and their husbands. METHODS: Pregnant women in whom GBS infections could be detected during 26 to 30 weeks of pregnancy and their husbands were studied during the two periods of August 1994 through May 1995 (Period A, 243 couples) and June through September 1997 (Period B, 141 couples). A urine sample was collected from a husband in the same morning when the vagina of his wife was tested for GBS. GBS were also classified according to their serotypes in 34 couples during Period A and B. RESULTS: In the two periods, GBS was detected in 18.1 and 19.3% of the wive's vaginal cultures, and in 19.1 and 17.0% of husbands' urinary cultures, respectively. There were no significant differences of the rate of GBS detection between the spouses, and also between the two trials. A high possibility of GBS infection was found in a couple when either of the spouses was possible to GBS. The serotypes of 31 of the 34 couples (91.2%) were identical. CONCLUSION: It is suggested that GBS can be sexually transmitted, and cause reinfection between spouses in spite of antepartum medication.

[Clinical results of repeated intraperitoneal administration of CDDP in patients with ovarian cancer].

CDDP was intraperitoneally administered to 45 ovarian cancer patients (9 cases in Stage Ic, 9 cases in Stage II, 19 cases in Stage III and 8 cases in Stage IV) as the first line chemotherapy to examine response rates and cumulative survival rates by Kaplan-Meier method. Among 18 cases with measurable tumor, there were 5 CR cases, 6 PR cases, 4 NC cases and 3 PD cases. Eleven out of 18 responded, for a response rate of 61.1%. The 3- and 5-year survival rates were 88.9% and 88.9% in Stage I, 46.7% and 0% in Stage II, 48.6% and 41.7% in Stage III, and 0% and 0% in Stage IV, respectively. The 3- and 5-year survival rates in patients with residual tumor smaller than 2 cm in diameter after the first surgery in Stage III or IV were 76.9% and 61.4% respectively, in contrast to 11.5% and 11.5% in patients with residual tumor of 2 cm or larger in diameter. Thus, a significantly better prognosis was demonstrated in patients with residual tumor smaller than 2 cm. These results indicate that intraperitoneal administration of CDDP demonstrated high response rates and proved to be useful as the first line chemotherapy, yet did not manage to improve the long-term prognosis of patients with progressive cancer.

[Positive rate of Chlamydia trachomatis antigen detected by the simultaneous sampling of the uterine cervix, uterine cavity and urinary tract and its relation to serum antibody titers].

The presence or absence of Chlamydia trachomatis antigen in the uterine cervix, uterine cavity and urinary tract was investigated by EIA (Chlamydiazyme) in 159 patients, in addition to the measurement of serum antibody titers in 120 of them by indirect enzyme immunoassay (IPAzyme). The results obtained were as follows. 1. The antigen was detected from one of the 3 sites in 13.8%. Patients in their twenties or younger had the highest positive rate (22.2%) and also the highest incidence of multiple lesions. 2. Patients with irregular hemorrhage from the uterine cavity had a high detection rate. 3. Detection rates for the uterine cervix, uterine cavity and urinary tract were 11.9%, 6.9% and 9.4% respectively. 4. As for overlap infection, the antigen was detected from 1, 2 and 3 sites in 7, 7 and 8 of 22 patients, respectively. 5. The incidence of active infection was significantly higher in antigen-positive patients than in antigen-negative patients, while no difference was observed in antibody titers by the increasing number of antigen-positive sites. These results suggested that the examination of the Chlamydia trachomatis antigen in the uterine cervix alone is insufficient, to determine the true actual prevalence of the organism.

[Cumulative survival rate of chemotherapy with CDDP for malignant ovarian tumors].

The current study covered 159 patients with primary malignant ovarian carcinoma who underwent various kinds of chemotherapy between 1977 and 1987. The cases in each stage were first divided into two groups. Group A (CDDP Group) and Group B (non-CDDP Group), for comparative analysis. The stage I Group was further divided into Subgroup A (CAP Group) and Subgroup B (FAM Group). Similarly, the Stage III Group was subdivided into Subgroup A (three or more courses of ip administration of CDDP). Subgroup B (three or more courses of iv administration of CDDP centering on CAP), Subgroup C (FAM Group), and Subgroup D (non-CDDP Group). In Stage I, the five-year survival rate in Group A was 94% and the comparable figure in Group B was 59%. In Stage III, the two-year and five-year survival rates were 31% and 11% for Group A as opposed to 24% and 18% for Group B. In Stage Ia, the five-year survival rate for Subgroup A was 90% as compared to 75% for Subgroup B. In Stage III, the two-year survival rate for Subgroup A was 67% as compared to 28% for Subgroup B and 30% for Subgroup C. This indicated a very good prognosis in Subgroup A as compared with the other two subgroups.

[Development of gamete intrafallopian transfer with preincubated preovulatory oocytes (new GIFT) and analysis of clinical data].

We developed a new treatment, Gamete Intrafallopian Transfer with the preincubated oocyte (New GIFT) and applied this method to all kinds of infertility where the patient had at least one tube. We performed 114 New GIFTs and dealt with the factors which influenced the establishment of pregnancy. 1. The pregnancy rate was 37%/cycles (42/114), 42%/patients (42/100) and the abortion rate was 19% (8/42). These results show that the New GIFT was more efficient than the original GIFT. 2. The most important factor for the establishment of pregnancy among the semen parameters was sperm motility, especially at the time of insemination. The pregnancy rate increased as sperm motility became higher. The sperm count did not influence the pregnancy rate significantly except in severe cases of oligozoospermia. 3. The most important factor in oocyte assessment was the number of mature oocytes. The number of oocytes in the pregnant group was much more than that in the nonpregnant group, but the total number of follicles in the pregnant group was found to be from 3 to 7 follicles. No pregnancy occurred when the number of follicles was greater than 11. These results suggested that existence an optimum number of oocytes. Conditions of the corona-cumulus component complex closely related to the establishment of pregnancy. The pregnancy rate was about 60% when more than 2C (-) oocytes (almost all cumulus cells were dispersed) were transferred, but it was only 5% when only C (+) oocytes (hardly any cumulus cells were dispersed) were transferred. 4. The most effective luteal support regimen was the pill. The administration of progesterone induced a high percentage of abortions.