Effects of a foot bath containing green tea polyphenols on interdigital tinea pedis.

BACKGROUND: It has been shown that green tea polyphenols (GTP) can directly kill Trichophyton in vitro; however, there are no published clinical studies that show anti-fungal activity of GTP. OBJECTIVES: To identify the effects of GTP on interdigital tinea pedis in elderly patients. METHOD: Ninety-four patients with interdigital tinea pedis were enrolled and were either given a lukewarm water foot bath containing GTP or placebo treatment. Effects of GTP were assessed based on changes in the size of the affected area, the rate of recurrence, microscopy findings, and overall assessment of skin changes. RESULTS: After 12 weeks of treatment with either GTP or placebo, a significant reduction in the size of the affected area was observed (p<0.001). There were no significant differences between the GTP or placebo groups in the size of the affected area (p=0.638), the recurrence rate (p=0.172), or the microscopy findings (p=1.000). However, the overall assessment demonstrated significant improvements (p=0.010) in the GTP group. CONCLUSIONS: These results show that GTP was effective in improving the symptoms of tinea pedis in comparison to only lukewarm water. Our results suggest that GTP could have anti-fungal activity.

[Case of infectious spondylitis presenting as exudative pleural effusion].

A 59-year-old woman with lumbago, presented with cough and right chest pain. Her chest X-ray showed right pleural effusion, and laboratory studies revealed elevated levels of serum C-reactive protein. Right bacterial pleuritis and empyema was diagnosed based on an analysis of the pleural effusion and pus. She was treated with antibiotics and both the right pleural effusion and pus were drained with a chest tube. Staphylococcus aureus was cultured from the pleural effusion and pus. Her fever and chest pain improved after this treatment, however, the lumbago took a sharp turn for the worse. A spinal MRI showed an increased signal intensity at the level of T11-12, thus suggesting a disk space infection and spondylitis with an epidural abscess. Thereafter, she developed left pleural effusion, and the effusion was drained. Her infection was cured with long-term administration of antibiotics. However, the infectious spondylitis relapsed after four months, and she therefore had to undergo surgery. This case suggested that infectious spondylitis produced the exudative pleural effusion. Bacterial pleuritis, empyema and exudative pleural effusion must therefore be treated while keeping in mind the possibility of infectious spondylitis.