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Tumori ; 89(4 Suppl): 7-8, 2003.
Article in Italian | MEDLINE | ID: mdl-12903531

ABSTRACT

A prospective phase II study was conducted to evacuate toxicity and results of preoperative radiochemotherapy in locoregionally advanced rectal cancer (LARC). A total of 33 patients entered the study and received 45 Gy to the pelvis plus a supplemental boost of 5.4-9 Gy concurrently with 5 FU c.i. at a dose of 225-275 mg/m2. Thirty patients were operated after 5-7 weeks (20 anterior resection and 10 abdominoperineal excision). In 14 patients (47%) a downstaging was observed, 5 patients experienced a complete clearance of the primary tumor. After a median of 14 months (range, 5-27), 23 patients, are alive and well. And 8 patients experienced a disease progression (4 local-regional and 4 distant). Our results provide further evidence of the utility and effectiveness of preoperative radiochemotherapy in LARC.


Subject(s)
Adenocarcinoma/therapy , Antimetabolites, Antineoplastic/therapeutic use , Chemotherapy, Adjuvant , Fluorouracil/therapeutic use , Neoadjuvant Therapy , Radiotherapy, Adjuvant , Radiotherapy, High-Energy , Rectal Neoplasms/therapy , Adenocarcinoma/drug therapy , Adenocarcinoma/mortality , Adenocarcinoma/radiotherapy , Adenocarcinoma/surgery , Adult , Aged , Combined Modality Therapy , Disease Progression , Disease-Free Survival , Female , Humans , Male , Middle Aged , Photons/therapeutic use , Prospective Studies , Rectal Neoplasms/drug therapy , Rectal Neoplasms/mortality , Rectal Neoplasms/radiotherapy , Rectal Neoplasms/surgery , Remission Induction , Treatment Outcome
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