[Prospects of drinking mineral water in the rehabilitation of patients with coronavirus (COVID-19) infection: analysis of the main sanogenetic mechanisms]. / Perspektivy primeneniya pit'evykh mineral'nykh vod v reabilitatsii patsientov s koronavirusnoi (COVID-19) infektsiei: analiz osnovnykh sanogeneticheskikh mekhanizmov.

This review provides an analysis of the main mechanisms of the therapeutic and prophylactic effects of drinking mineral water concerning the rehabilitation of new coronavirus infection convalescents. When considering the sanogenetic potential of mineral water for drinking, it was noted that in the mechanisms of their systemic effects, a major role belongs to the nonspecific hormone-stimulating effect in the form of a pronounced activation of the gastroenteropancreatic endocrine system, capable of integrating substance and energy exchange following the current needs of the body and excrete vasoactive factors modulating the vital functional systems activity. The maximum effect of this system is promoted by the intake of mineral water with a high content of hydrocarbonate ions, magnesium, and sodium, as well as carbon dioxide saturation, but with general mineralization of water within the range from 5-6 to 11-13 g/L. The observed stimulating effect of mineral water on the adaptation processes allowed us to theoretically substantiate and convincingly prove the benefits of using this natural healing factor for the primary prevention of disorders in various functional systems and their hormonal regulation. The effects of drinking mineral water on various inflammatory states, resistance to hypoxia, microcirculatory tissue perfusion, and the state of the cardiovascular system were shown. It is concluded that the potential effectiveness of drinking mineral water as a part of comprehensive programs of medical rehabilitation of new coronavirus infection convalescents.

[Predictive significance of initial morpho-functional characteristics for the evaluation of effectiveness of remedial correction of arterial hypertension].

Analysis of effectiveness of spa-and-resort treatment of 154 patients with arterial hypertension and metabolic disturbances has demonstrated predictive value of variations of biological characteristics which suggests their important contribution to beneficial outcome of rehabilitative therapy. Results of the study made it possible to distinguish the most essential aspects of metabolism and its regulation related to the success of spa-and-resort treatment.

[Investigation of antioxidative effects of phytotherapy combined with vetoron treatment in patients presenting with arterial hypertension].

Biochemical effects of phytoinhalation and oral administration of biologically active additives containing beta-carotene (e.g. vetoron) are evaluated with special reference to changes in lipid peroxidation. Systemic analysis of the mechanisms of antioxidative effects of phytotherapy demonstrated the leading role of activation of vegetative homeostasis-regulating centres and central stress-limiting systems as well as direct action of antioxidative ingredients comprising the formulation. The study showed that combination of phytotherapy and vetoron allowed the overall antioxidative efficiency of these treatments to be considerably increased due to their action on different targets. It is concluded that the proposed method promotes effectiveness of combined rehabilitative treatment in patients with arterial hypertension due to correction of disturbed lipid peroxidation.

[Efficiency of non-medicamentous therapy and evaluation of intersystemic relationship between functional reserves of the organism and periodontal status in patients with chronic generalized periodontitis].

Mechanisms of mutual influence and aggravation of splanchnic organ and oral cavity diseases are discussed in the context of the integral anthropological approach. The systemic character of analysis of pathogenetic mechanisms of chronic generalized periodontitis dictates the necessity of an absolutely new conceptual outlook of organization and implementation of medical and preventive measures designed to activate sanogenetic responses and to enhance the regulatory potential and functional reserves of the organism in the presence of developing periodontitis. It was shown that inclusion of intermittent hypoxic training in the combined rehabilitative treatment of the patients with chronic periodontitis substantially promotes corrective influences on periodontal tissues and ensures stable clinical effect.

[Phytotherapy of arterial hypertension with concomitant obesity in sanatorium-resort conditions].

Efficiency of different phytotherapeutic modalities (per os, baths, inhalation) in patients with arterial hypertension was evaluated under conditions of balneologic treatment. Modes of their curative action and mechanisms of the disease are considered. Comparative analysis of non-medicamentous technologies used in balneologic practice is presented. It is shown that hormonal regulation of carbohydrate and lipid metabolism plays the key role in the realization of therapeutic effects of phytopreparations. The improvement of functional activity of the cardiovascular system turns out to correlate with reduced clinical manifestations of metabolic syndrome.

[Influence of food biologically active supplements on the immune status of healthy volunteers].

The authors show that use of biologically active additions to food Bio-Normalizer, Oxine, Gonsyn and Lovsin is effective method of immune correction of human functional state. These biologically active additions to food lead to increase 15-25 per cent of T-helper activity, activates 20-32 per cent of B-component of immune system, enhance of immunocompetent cells cooperation and rise human antibacterial resistance. That all optimizes immune response and increases resistance to extreme impacts.

[Fat loading test: biochemical criteria and informative value of the physical endurance assessment]. / Biokhimicheskie kriterii zhirovoi nagruzochnoi proby i ee informativnost' v otsenke perenosimosti fizicheskikh nagruzok.

Biochemical criteria of the fat loading test (FLT) were established and the search for interrelations between FLT biochemical variables and physiological parameters of dynamic physical testing (bicycle ergometry) was conducted in the experiment with participation of male volunteers. Relative gain in glucose, triglycerides, total cholesterol concentrations in blood, atherogenicity factor and insulin decrease after 3-hr FLT and reduction in blood concentrations of total cholesterol, insulin, hydrocortisone and testosterone after 9-hr FLT were ranked as reliable criteria. Rise in blood glucose and decrease in blood insulin after 3-hr FLT, and decrease in serum testosterone after 9-hr FLT were found to have prognostic value. Correlation between the FLT biochemical variables and physiological parameters as well as the package of regression analysis equations allow prediction for physical endurance. Yet, analysis of the correlation suggested that desensitization to insulin of the cell membrane cells should be a pathogenic mechanism of physical endurance decrement.

[Antioxidant effects of vetoron in flying personnel with arterial hypertension]. / Antioksidantnaia éffektivnost' vetorona u lits letnogo sostava s arterial'noi gipertenziei.

The purpose of the investigation was to assess the possibility to control free radical oxidation in patients with cardiovascular pathologies with the help of vetoron. This was the first attempt to study effects of a beta-carotene (vetoron) on lipid peroxidation and the activity of antioxidant defense enzymes in flying personnel with cardiovascular pathologies (hypertension and neurocirculatory dystonia). Therapeutic effect of the medicament was evaluated by its action on peroxide metabolism (malonic dialdehyde, acyl hydroperoxides and trien conjugates, Schiff bases) and stimulation of the antioxidant defense enzymes (catalase and glutathione reductase). Results of the investigation pointed to the inhibition of lipid peroxidation against activation of the antioxidant defense enzymes in patients with hypertension who had been given the course of vetoron; however, in patients with neurocirculatory dystonia.

[Metabolic effects of static physical load under the conditions of pharmakologicheskoi mobilization of physical endurance]. / Metabolicheskie éffekty staticheskoi fizicheskoi nagruzki v usloviiakh farmakologicheskoi vynoslivosti.

The model of static physical loading (SPL) was used to study the biochemical effects of graded static tension and potentiality for pharmacological mobilization of physical endurance with participation of male volunteers. A close pathogenetic linkage between the established metabolic effects of the model and their adaptive adequacy to the stressing factor show that there is every reason to arrange the observed shifts in a SPL syndrome. The SPL syndrome is primarily manifested by exaggerated tone of the adrenoactive structures, inhibition of insulin production by the pancreas, activation of the neuropeptide anti-stress mechanisms, predominant utilization of the lipid substrate in energy production, intensification of protein catabolism, and increase in myocyte membrane permeability due to energy deficit. The investigation demonstrated that improvement of static physical endurance can be attained with a mobilizing stimulator (sidnocarb) and a combination of sidnocarb with a nonmediatory preparation (bemytil). This pharmacological combination levels side-effects of exorbitant activation of the adrenal system. On the contrary, a metabolic vitamin-microelements complex ("cocktail C") perceivably enhances SPL endurance (sidnocarb dose was lowered in three times), possesses the stress-protective effect, the ability to moderate the intensity of free (uninvolved in phosphorylation) oxidation and to optimize energy-plastic processes with predominant utilization of the lipid substrate.

[Informational assets of glucose tolerance test in evaluation of endurance to psychoemotional stress]. / Informativnost' testa tolerantnosti k gliukoze v otsenke perenosimosti psikhoémotsional'nykh nagruzok.

Psychoemotional stresses were simulated in male volunteers in order to evaluate the predictive value of the glucose-tolerance test patterns. As was found, the predictive information is provided by the following parameters: Rafalsky and Boduen coefficients, glucose levels during 60-min testing, and the hypoinsulinemia coefficient. Operator's performance under the condition of time constraint is directly dependent on the insulin content. Based on results of the discriminative analysis key guidelines for classification of individuals by their resistance to the psychoemotional factor were proposed. In view of the informational assets the authors suggest that this approach should be more actively used in development of programs of functional testing of humans in extreme environments. Analysis of determined relationships gave rise to the supposition that desensitization of cell membrane receptors to insulin is the most probable cause for the detriment of the resistance to psychoemotional stresses.

[Predictive information of basic indices of biochemical status of a man in evaluating the tolerance to acute hypoxia]. / Prognosticheskaia informativnost iskhodnykh pokazatelei biokhimicheskogo statusa cheloveka v otsenke perenosimosti ostroi gipoksicheskoi gipoksii.

Under simulation of acute hypoxic hypoxia with participating the volunteers (men) there has been studied the predictor significance of the biochemical indices characterising an intensity of lipoperoxidation process, hormonal status and level of fermentemia. It is indicated that the following indices, namely, LDH, a [symbol: see text]-DPDH, MPD, secondary products of POL, SOD, insulin, cAMP and cAMP/cGMP have the prognostic validity. The revealed combination of the reliable relations was approximated by the equations of one-factor regression. As this takes place, the analysis of the presented dependencies between tolerance for hypoxia and biochemical indices allowed one to recognize the most probable mechanisms of resistance to the effect of this factor. The performed discrimination analysis for 6 biochemical variables (cAMP, LDH, SOD, MPO, MDA, TC) made it possible to create discriminant equations and to formulate the decisive rules to class the individuals into the ranks with different tolerance to the oxygen deficiency. The high informative capacity of the mentioned approach is recommended by the authors for a more wide use when developed the expert system to evaluate the human functional state as applied to the effect of extreme environmental factors and activity.

[Pharmacological correction of lipid peroxidation during hypoxia and possibility to enhance human resistance to high altitude by using preparations of the metabolic type of action]. / Farmakologicheskaia korrektsiia protsessa lipoperoksidatsii pri gipoksii i vozmozhnost' povysheniia vysotnoi ustoichivosti cheloveka s pomoshch'iu preparatov metabolicheskogo tipa deistviia.

In simulating acute hypoxic hypoxia with the participation of male volunteers, the authors investigated the antihypoxic and antioxidative activity of metabolic drugs (jakton, amtizole succinate, nootropil, probucol, and a mixture which consists of jakton, amtizole succinate, and probucol). The pharmaceuticals were shown to have heterodirectional effects on lipid peroxidative processes. Drugs having a pronounced antioxidative activity (such as probucol and the mixture) promotes oxygen utilization during hypoxia and posthypoxic reoxygenation chiefly by the oxygenase pathway. This rearrangement of oxygen utilization processes caused an increase in human high-altitude resistance. The use of the above drugs is a promising trend in the development of an adaptative response to hypoxia in persons engaged in hazardous jobs.

[Methodological aspects of pharmacological regulation of emotional stress in persons with dangerous occupations]. / Metodologicheskie aspekty farmakologicheskoi reguliatsii émotional'nogo stressa u lits opasnykh professii.

The significance of the emotional stress problem for persons of dangerous professions makes it necessary to search for the optimal procedure for emotional status correction. However, taking into account the specific features of military specialists' professional activity, it is highly difficult to choose a single drug. The authors apply a differential approach to solving the problem by considering the efficacy of tranquilizers, stimulants, adrenergic blocking agents, and adaptogens. The use of anxiolytics corrects an emotional response to the level which has marked adaptational sense. A combination of tranquilizers with stimulants is beneficial for the prevention or abortion of fatigue states. beta-adrenergic blockers act as stress protective agents in the cases when the implementation of highly coordinated skills is of crucial importance. By evoking physiological and biochemical changes in the body, adaptogens are involved in the elaboration of an adequate behavioral pattern and in adaptive rearrangement under the influence of unfavourable factors of the environment and activities.

[Biochemical evaluation of various respiration conditions during simulation of extended flight]. / Biokhimicheskaia otsenka razlichnykh rezhimov dykhaniia v usloviiakh modelirovaniia dlitel'nogo poleta.

During a simulated long-term mission with participation of male volunteers biochemical effects of various conditions of oxygen supply including breathing the cabin air at 2.4 km, pure oxygen, and intermittent hypoxia/hyperoxia, i.e. breathing the cabin air for 50 min and pure O2 for 10 min every hour in flight were studied. This assessment of respiration conditions by biochemical criteria allowed to recognize the combination of short hyperoxia and cabin air as the optimum to be taken into accounted in attacking the problem of oxygen supply of aviators in extended flights.

[New adenosine derivatives as agents to prevent postischemic disorders]. / Novye proizvodnye adenozina kak sredstva profilaktiki postishemicheskikh narushenii.

The authors studied prophylactic action of adenosine analogs during ischemic liver damage. Hepatoprotective action of adenosine analogs was established.