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1.
Int J Cardiol ; 215: 120-6, 2016 Jul 15.
Article in English | MEDLINE | ID: mdl-27111173

ABSTRACT

BACKGROUND: We evaluated the association between sodium intake and plasma renin levels in the cross sectional study and meta-analysis of randomized controlled trials, whether there is a persistent elevation of plasma renin by longer-term sodium intake restriction. METHODS: Plasma renin activity (PRA) and 24-h urine sodium (24HUNa) excretion were measured from individuals randomly selected from a community. Simple and multiple linear regression analyses adjusted for age, 24-h systolic blood pressure, 24-h average heart rate, fasting blood glucose and gender were performed. For meta-analysis, 74 studies published from 1975 to mid-2014 were identified in a systematic literature search using EMBASE, CINAHL, and MEDLINE. Random effects meta-analyses and a meta-regression analysis were performed. RESULTS: Among the 496 participants recruited, 210 normotensive and 87 untreated hypertensive subjects were included in the analysis. There was no significant association between PRA and 24HUNa in the total population, or hypertensive and normotensive individuals. In the meta-analysis, the standard mean difference (SMD) of renin level by sodium intake reduction was 1.26 (95% CI: 1.08 to 1.44, Z=12.80, P<0.001, I(2)=87%). In the meta-regression analysis, an increase in a day of intervention was associated with a fall in SMD by -0.04 (95% CI: -0.05 to -0.02, Z=-5.27, P<0.001, I(2)=86%), indicating that longer duration of reduced sodium intake would lead to lesser SMD of renin level. CONCLUSIONS: The present population based cross-sectional study and meta-analysis suggests that prolonged reduction in sodium intake is very unlikely associated with elevation of plasma renin levels.


Subject(s)
Population Surveillance , Randomized Controlled Trials as Topic , Renin/blood , Sodium Chloride, Dietary/administration & dosage , Sodium/urine , Blood Pressure/drug effects , Blood Pressure/physiology , Cross-Sectional Studies , Humans , Hypertension/blood , Hypertension/diagnosis , Hypertension/urine , Population Surveillance/methods , Randomized Controlled Trials as Topic/methods
2.
Am J Cardiol ; 86(7): 791-5, A9, 2000 Oct 01.
Article in English | MEDLINE | ID: mdl-11018205

ABSTRACT

We evaluated the influences of minor edge dissections on late angiographic in-stent restenosis in 327 patients with 348 lesions (281 lesions without edge dissection and 67 lesions [19.3%] with edge dissection); the angiographic restenosis rate was 29.9% in the lesions with edge dissections versus 25.3% without edge dissections (p = 0.540). The minor non-flow-limiting dissections at the edge of stents may not be associated with the development of late angiographic in-stent restenosis.


Subject(s)
Coronary Disease/therapy , Coronary Vessels/injuries , Stents/adverse effects , Coronary Angiography , Coronary Disease/diagnostic imaging , Coronary Vessels/diagnostic imaging , Female , Follow-Up Studies , Humans , Male , Middle Aged , Recurrence , Treatment Outcome , Ultrasonography, Interventional
3.
Eur Heart J ; 21(21): 1785-9, 2000 Nov.
Article in English | MEDLINE | ID: mdl-11052843

ABSTRACT

AIMS: Angioplasty of lesions in small coronary arteries remains a significant problem because of the increased risk of restenosis. The aim of this study was to compare the efficacy of elective coronary stent placement and optimal balloon angioplasty in small vessel disease. METHODS: One hundred and twenty patients with lesions in small coronary arteries (de novo, non-ostial lesion and reference diameter <3 mm) were randomly assigned to either balloon angioplasty or elective stent placement (7-cell NIR stent). The primary end-point was restenosis at 6 months follow-up. Optimal balloon angioplasty was defined as diameter stenosis less than or = 30% and the absence of major dissection after the angioplasty, and crossover to stenting was allowed. RESULTS: Baseline clinical and angiographic characteristics were similar in the two groups. Procedure was successful in all patients, and in-hospital events did not occur in any patient. However, 12 patients in the angioplasty group were stented because of suboptimal results or major dissection. Postprocedural lumen diameter was significantly larger in the stent group than in the angioplasty group (2.44 +/- 0.36 mm vs 2.14 +/- 0.36, P<0.05, respectively), but late loss was greater in the stent group (1.12 +/- 0.67 mm vs 0.63 +/- 0.48, P<0.01, respectively). The angiographic restenosis rate was 30.9% in the angioplasty group, and 35.7% in the stent group (P = ns). Clinical follow-up was available in all patients (15.9 +/- 5.7 months) and clinical events during the follow-up were similar in both groups. CONCLUSIONS: These results suggest that optimal balloon angioplasty with provisional stenting may be a reasonable approach for treatment of lesions in small coronary arteries.


Subject(s)
Angioplasty, Balloon, Coronary/methods , Coronary Disease/therapy , Coronary Vessels , Stents , Adult , Aged , Chi-Square Distribution , Coronary Angiography , Coronary Disease/diagnostic imaging , Coronary Vessels/pathology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Probability , Reference Values , Treatment Outcome
4.
Am J Cardiol ; 86(5): 499-503, 2000 Sep 01.
Article in English | MEDLINE | ID: mdl-11009265

ABSTRACT

This study evaluates the impact of cilostazol on post-stenting restenosis. Cilostazol is a potent antiplatelet agent with antiproliferative properties. Few data are available about the effect of cilostazol on poststenting restenosis. Four hundred nine patients (494 lesions) who were scheduled for elective stenting were randomized to receive aspirin plus ticlopidine (group I, n = 201, 240 lesions) or aspirin plus cilostazol (group II, n = 208, 254 lesions), starting 2 days before stenting. Ticlopidine was given for 1 month and cilostazol for 6 months. Follow-up angiography was performed at 6 months, and clinical evaluation at regular intervals. Baseline characteristics were similar between the 2 groups. The procedural success rate was 99.6% in group I and 100% in group II. There were no cases of stent thrombosis after stenting. Angiographic follow-up was performed in 380 of the 494 eligible lesions and the angiographic restenosis rate was 27% in group I and 22.9% in group II (p = NS). However, diffuse type in-stent restenosis was more common in group I than in group II (54.2% vs 26.8%, respectively, p <0.05). In diabetic patients, the angiographic restenosis rate was 50% in group I and 21.7% in group II (p <0.05). Clinical events during follow-up did not differ between the 2 groups. In conclusion, aspirin plus cilostazol seems to be an effective antithrombotic regimen with comparable results to aspirin plus ticlopidine, but it does not reduce the overall angiographic restenosis rate after elective coronary stenting.


Subject(s)
Platelet Aggregation Inhibitors/therapeutic use , Stents , Tetrazoles/therapeutic use , Angioplasty, Balloon, Coronary , Aspirin/adverse effects , Aspirin/therapeutic use , Cilostazol , Coronary Angiography , Coronary Disease/therapy , Disease-Free Survival , Drug Therapy, Combination , Follow-Up Studies , Humans , Phosphodiesterase Inhibitors/adverse effects , Phosphodiesterase Inhibitors/therapeutic use , Platelet Aggregation Inhibitors/adverse effects , Recurrence , Tetrazoles/adverse effects , Ticlopidine/adverse effects , Ticlopidine/therapeutic use
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