Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Inflamm Res ; 59(11): 971-8, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20473630

ABSTRACT

OBJECTIVE AND DESIGN: A 6-month, randomized clinical study was conducted to evaluate the effect of a ribonuclease-enriched lactoferrin (R-ELF) supplement on the circulating cytokine levels and bone health of postmenopausal women. SUBJECTS: Thirty-eight healthy postmenopausal women, aged 45-60 years, were randomized into placebo and R-ELF groups. TREATMENT: The R-ELF group was supplemented with R-ELF (2 × 125 mg/day) and calcium (100% RDA), while the placebo group received only the calcium supplement. METHODS: Serum levels of receptor activator for NF-κB ligand (RANKL), C-reactive protein (CRP) and various pro- and anti-inflammatory cytokines were determined by ELISA. RESULTS: Pro-inflammatory cytokines IL-6 and TNF-α decreased significantly (-44 and -10%, respectively) while anti-inflammatory IL-10 increased (140%) due to R-ELF supplementation at the end of study. RANKL and CRP were modestly reduced (-50%) relative to their placebo levels, although RANKL elevated initially. CONCLUSIONS: R-ELF supplementation showed beneficial effects towards improvement of inflammatory status in postmenopausal women.


Subject(s)
Dietary Supplements , Inflammation/immunology , Lactoferrin , Milk/enzymology , Postmenopause , Ribonucleases/administration & dosage , Animals , Cattle , Cytokines/blood , Cytokines/immunology , Female , Humans , Inflammation/blood , Lactoferrin/administration & dosage , Lactoferrin/chemistry , Middle Aged , Placebos
SELECTION OF CITATIONS
SEARCH DETAIL
...