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Liver Int ; 27(5): 627-32, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17498247

ABSTRACT

BACKGROUND: The highest incidence of hepatitis B virus (HBV)-associated vasculitis in the world has been reported in Alaska Natives. We examined the incidence of HBV-associated vasculitis before and after mass HBV vaccine immunization and the association between HBV genotype and vasculitis in a population-based cohort study in Alaska natives chronically infected with HBV. METHODS: Genotyping was performed in vasculitis cases and 644 hepatitis B-positive controls without vasculitis using polymerase chain reaction and sequencing of the S gene. Occurrence of HBV vasculitis from 1974 to 2004 was calculated. HBV vasculitis patients and controls were also tested for basal core promoter and precore mutations. RESULTS: Fifteen cases of HBV-associated vasculitis were identified: 13 (86%) had genotype D and one each genotype A and F. Genotype D was more commonly found in patients with vasculitis than controls [odd ratio (OR)=5.9, confidence interval (95% CI) 1.2, 21.8; P<0.015). CONCLUSIONS: HBV-associated vasculitis was associated with genotype D.


Subject(s)
DNA, Viral/blood , Hepatitis B virus/genetics , Hepatitis B/complications , Inuit , Vasculitis/etiology , Adolescent , Adult , Aged , Case-Control Studies , Child , Child, Preschool , Female , Genes, Viral , Genotype , Hepatitis B/ethnology , Hepatitis B/virology , Humans , Male , Middle Aged , Mutation , Treatment Outcome , Vasculitis/ethnology
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