ABSTRACT
The relationship between glucose-6 phosphate dehydrogenase (G6PD) deficiency and jaundice in the newborn period is well recognized. However, there is concern about the increasing incidence of kernicterus being reported worldwide, especially due to unrecognized G6PD deficiency and early discharge from hospital after birth. We report a case series of kernicterus from a set-up where the high prevalence rate of G6PD deficiency is known. Fourteen cases of kernicterus were seen during a time period of 6 years, 71 per cent of them had G6PD deficiency. Recent literature is reviewed and possible preventive measures in the light of current information and practices are suggested.
Subject(s)
Glucosephosphate Dehydrogenase Deficiency/complications , Jaundice, Neonatal/complications , Kernicterus/etiology , Female , Humans , Infant, Newborn , Jaundice, Neonatal/diagnosis , Jaundice, Neonatal/prevention & control , MaleABSTRACT
Fifteen low birth weight premature infants with a diagnosis of PDA were administered 0·2 mg/kg of indomethacin orally, 3 doses at 12 hourly intervals. The results were compared with 18 prematures who were managed by fluid restriction (80-100 ml/kg/day) and decongestive therapy. Nine out of the 15 cases who received indomethacin met with the criteria of response, compared with only 2 out of 18 in whom there was spontaneous closure (P<0·01). Eleven of 15 cases who received indomethacin survived compared to only 6 of 18 in the control group (P<0·01). Overall mortality due to PDA alone was 58·9 per cent. Indomethacin when administered orally and sufficiently early, is safe and effective in closing PDA in premature infants. This modality of treatment is feasible in the Indian set up.
