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J Nat Prod ; 62(6): 868-72, 1999 Jun.
Article in English | MEDLINE | ID: mdl-10395505

ABSTRACT

Nine 3,4-secoapotirucallanes, argentinic acids A-I, were isolated from the bark of Aglaia argentea and transformed to their methyl esters 1-9. The structures were determined by spectral and chemical means. Compounds 1-8 showed moderate cytotoxic activity against KB cells (IC50 1.0-3.5 microg/mL).


Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Plants, Medicinal/chemistry , Triterpenes/isolation & purification , Antineoplastic Agents, Phytogenic/pharmacology , Chromatography, Thin Layer , Drug Screening Assays, Antitumor , Humans , Hydrolysis , KB Cells , Magnetic Resonance Spectroscopy , Malaysia , Plant Extracts/chemistry , Triterpenes/pharmacology , Tumor Cells, Cultured
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