1.
Org Biomol Chem
; 21(31): 6289-6292, 2023 Aug 09.
Article
in English
| MEDLINE
| ID: mdl-37505101
ABSTRACT
Total syntheses of fawcettimine-class Lycopodium alkaloids having an imino bridge between C5 and C13 were accomplished. Fawcettimine was first prepared in 10 steps from a known compound, and the characteristic structures, including the imino bridge, were constructed via the formation of a bridgehead imine.
2.
Org Lett
; 24(44): 8228-8232, 2022 11 11.
Article
in English
| MEDLINE
| ID: mdl-36305771
ABSTRACT
A synthetic route to ecteinascidin 743 has been established via an intramolecular cascade Heck reaction to construct the diazabicyclo[3.3.1]nonane skeleton while controlling the two contiguous stereogenic centers. The strategically formed five-membered ring was oxidatively cleaved to generate a dialdehyde intermediate, from which the B ring of ecteinascidin 743 was constructed.