ABSTRACT
Gallic acid (1) and methyl gallate (2) were isolated from Juca, a Brazilian folk medicine, fruits of Caesalpinia ferrea MART (Leguminosae), decreased significantly the average number of papillomas per mouse in the experiment of the promoting effects of 12-O-tetra- decanoylphorbol-13-acetate (TPA) on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene (DMBA).
Subject(s)
Anticarcinogenic Agents/pharmacology , Caesalpinia/chemistry , Gallic Acid/analogs & derivatives , Medicine, Traditional , Plant Extracts/pharmacology , Skin Neoplasms/chemically induced , Skin Neoplasms/prevention & control , 9,10-Dimethyl-1,2-benzanthracene/pharmacology , Animals , Anticarcinogenic Agents/chemistry , Brazil/ethnology , Female , Fruit/chemistry , Gallic Acid/isolation & purification , Gallic Acid/pharmacology , Mice , Mice, Inbred ICR , Papilloma/chemically induced , Papilloma/prevention & control , Phytotherapy , Plant Extracts/chemistry , Tetradecanoylphorbol Acetate/pharmacologyABSTRACT
The anti-tumor promoting effects of fruits of Caesalpinia ferrea MART. (Leguminosae) were tested by the in vitro Epstein-Barr virus early antigen (EBV-EA) activation assay, and its active constituents were identified as gallic acid (1) and methyl gallate (2). A total of 49 related compounds of 1 and 2 were analysed for the effects by this assay, and the structure activity relationships have been proposed. Three acetophenone derivatives, 2,6-dihydroxyacetophenone (48), 2,3,4-trihydroxyacetophenone (50) and 2,4,6-trihydroxy- acetophenone (51) were found to show potent inhibitory activity.
