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Photoinduced cytotoxicity of a photochromic diarylethene via caspase cascade activation.

Okuda, Jun-ya; Tanaka, Yukimi; Kodama, Ryuhei; Sumaru, Kimio; Morishita, Kana; Kanamori, Toshiyuki; Yamazoe, Seiji; Hyodo, Kengo; Yamazaki, Shohei; Miyatake, Tomohiro; Yokojima, Satoshi; Nakamura, Sinichiro; Uchida, Kingo.

Chem Commun (Camb) ; 51(54): 10957-60, 2015 Jul 11.

Article in English | MEDLINE | ID: mdl-26063471

ABSTRACT

The photo-generated closed-ring isomer of bis(5-methyl-2-phenylthiazoyl)perfluorocyclopentene shows cytotoxicity to Madin-Darby canine kidney (MDCK) cells through a caspase cascade and induces apoptosis of cells.

Subject(s)

Caspases/metabolism , Cyclopentanes/chemistry , Fluorocarbons/chemistry , Animals , Apoptosis/drug effects , Apoptosis/radiation effects , Cyclopentanes/toxicity , Dogs , Fluorocarbons/toxicity , Isomerism , Madin Darby Canine Kidney Cells , Polymers/chemistry , Ultraviolet Rays

ABSTRACT

Subject(s)

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