ABSTRACT
Two new bisindole alkaloids, named cinereapyrrole A (1) and B (2), were isolated from wild fruit bodies of Arcyria cinerea and three new bisindole alkaloids (3-5) were isolated from wild fruit bodies of Lycogala epidendrum. Seven known bisindoles (6-12) were concomitantly obtained from them. The structures of the new compounds were elucidated by spectral data. Among these bisindole alkaloids, compound 12 showed cytotoxicity against cultured tumor cell lines.
Subject(s)
Dictyosteliida , Indole Alkaloids/chemistry , Indole Alkaloids/isolation & purification , Myxomycetes/chemistry , Myxomycetes/isolation & purification , Animals , Cytotoxins/chemistry , Cytotoxins/isolation & purification , HeLa Cells , HumansABSTRACT
Cycloanthranilylproline (1) and its derivatives (2--4) were isolated from field-collected fruit-bodies of a myxomycete Fuligo candida and their structures were elucidated by spectral data. Compound 4, which was contained in the water-soluble fraction of the extract of this myxomycete, was unstable and quite susceptible to decarboxylation to yield compound 2, which was a major constituent of the EtOAc-soluble fraction of this extract.
Subject(s)
Myxomycetes/chemistry , Proline/isolation & purification , Isatis/chemistry , Japan , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Proline/analogs & derivatives , Proline/chemistryABSTRACT
From a myxomycete Arcyria ferruginea, dihydroarcyriarubin C (1), a new bisindole alkaloid, has been isolated together with two known bisindoles, arcyriarubin C (2) and arcyriaflavin C (3), and arcyriaflavin C (3) was also isolated from Tubifera casparyi together with arcyriaflavin B (4). Arcyriaflavin C (3) exhibited cell cycle inhibition effect at G1 and G2/M stage at 10 and 100ng/mL, respectively.
