[A case of lung cancer with small intestine metastasis with perforative peritonitis as the initial symptom].

Herein, we report a case oflung cancer with metastasis to the small intestine, with perforative peritonitis as the initial symptom. An 82-year-old man who had undergone subtotal gastrectomy and Roux-en-Y anastomosis for gastric cancer 8 years previously was admitted to our hospital with abdominal pain. We diagnosed the patient with gastrointestinal perforation, and a chest computed tomography(CT)scan showed a mass in the right lung. A laparotomy revealed a 4×3 cm sized intestinal tumor and intestinal perforation in the immediate vicinity ofthe anastomotic site. Segmentectomy ofthe small intestine was performed. Histological examination indicated that the tumor specimen was squamous cell carcinoma. Four months later, an abdominal CT scan showed multiple liver metastases, and the patient died 6 months after the operation because ofcachexia. At autopsy, a diagnosis ofsmall intestine metastatic tumor originating from squamous cell carcinoma of the lung was made. Although small intestine metastasis from lung cancer is rare, it should be considered when progressive abdominal symptoms are observed.

[A case of advanced gastric cancer effectively treated with weekly paclitaxel as neoadjuvant chemotherapy].

We report a patient with advanced gastric cancer responding remarkably to neoadjuvant chemotherapy consisting of weekly paclitaxel. The patient was a 50-year-old male who had large advanced gastric cancer, suspected of invasion to the duodenum and pancreas and severe lymph node metastasis [cT4 (pancreas), cN2, cH0, cP0, cM0, cStage IV]. He was treated with weekly paclitaxel as neoadjuvant chemotherapy. According to gastroscope and CT findings, a significant tumor reduction was obtained after 3 courses. Therefore, distal gastrectomy with D2 nodal dissection were performed. The histological diagnosis was pT2, pN2, pStage IIIA, and the histological effect of the main tumor was judged to be Grade 2. The patient has now been in good health without recurrence for 3 years after surgery. This case suggests that neoadjuvant chemotherapy with weekly paclitaxel is a potentially effective regimen for advanced gastric cancer.

A case of double gallbladder with adenocarcinoma arising from the left hepatic duct: a case report and review of the literature.

Double gallbladder is a rare congenital biliary anomaly, but an accessory gallbladder arising from the left hepatic duct is a more remarkably rare congenital anomaly. We report a case of double gallbladder with adenocarcinoma and gallstones, which was preoperatively diagnosed by endoscopic retrograde cholangiopancreatography (ERCP) and then confirmed by open laparotomy. A review of the literature is presented.

Tumorigenesis in infant C3H/HeN mice exposed to tritiated water (HTO).

The purpose of this study was to determine the carcinogenicity and retention of tritiated water (HTO) in mice. A two-part study was undertaken. In an HTO-incorporation study, both sexes of 12-day old C3H/HeN mice were i.p. injected with 3.70 MBq/pup of HTO and sacrificed 3 hr and 1, 3, 7, 14 days after HTO administration; in a carcinogenicity study, pups were given a single i.p. injection of HTO at doses of 0, 0.23, 0.92 and 3.70 MBq/mouse, and then observed for 14 months. The survival rates of both sexes slightly decreased upon increasing the HTO administered doses. The results indicated that the administration of HTO to infants led to a significant increase of liver tumors in male mice, but not in females. In female mice, ovarian tumors were observed for the high-dose group of injected HTO.