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1.
Int J Biol Macromol ; 268(Pt 1): 131590, 2024 May.
Article in English | MEDLINE | ID: mdl-38621563

ABSTRACT

This work aimed to prepare a new system for daunorubicin (DNR) delivery to improve therapeutic efficiency and decrease unwanted side effects. Typically, at first, a carboxylic acid functional group containing metal-organic framework (UiO-66-COOH) was synthesized in a simple way. Then, a third generation of citric acid dendrimer (CAD G3) was grown on it (UiO-66-COOH-CAD G3). Finally, the system was functionalized with pre-modified hyaluronic acid (UiO-66-COOH-CAD-HA). SEM analysis displayed that the synthesized particles have a spherical shape with an average particle size ranging from 260 to 280 nm. An increase in hydrodynamic diameter from 223 nm for UiO-66-COOH to 481 nm for UiO-66-COOH-CAD-HA is a sign of success in the performed reactions. Also, the average pore size was calculated at about 4.04 nm. The DNR loading efficiency of UiO-66-COOH-CAD-HA was evaluated at ∼74 % (DNR@UiO-66-COOH-CAD-HA). It was observed that the drug release rate at a lower pH is more than higher pH. The maximum hemolysis of <3 % means that the UiO-66-COOH-CAD-HA is hemocompatible. The use of DNR-loaded UiO-66-COOH-CAD-HA led to cell-killing of 77.9 % for MDA-MB 231. These results specified the great potential of UiO-66-COOH-CAD-HA for tumor drug delivery, so it could be proposed as a new carrier for anticancer agents to minimize adverse effects and improve therapeutic efficacy.


Subject(s)
Citric Acid , Daunorubicin , Dendrimers , Drug Carriers , Drug Liberation , Hyaluronic Acid , Daunorubicin/chemistry , Daunorubicin/pharmacology , Hyaluronic Acid/chemistry , Citric Acid/chemistry , Dendrimers/chemistry , Humans , Drug Carriers/chemistry , Metal-Organic Frameworks/chemistry , Hemolysis/drug effects , Biocompatible Materials/chemistry , Drug Delivery Systems , Particle Size , Cell Line, Tumor , Animals , Hydrogen-Ion Concentration , Phthalic Acids
2.
Chemosphere ; 352: 141397, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38325613

ABSTRACT

Currently, the presence of drugs used in the COVID-19 pandemic in water bodies is worrisome due to their high toxicity, which necessitates their critical removal by developing highly efficient adsorbents. Hence, in this study, alginate hydrogel beads of magnetic graphene oxide@MIL-88 metal-organic framework (GO@Fe3O4@MIL-88@Alg) were prepared for the first time and then utilized as a new absorption system for the removal of COVID-19 drugs such as doxycycline (DOX), hydroxychloroquine (HCQ), naproxen (NAP), and dipyrone (DIP) from aqueous solutions by batch adsorption manner. The effects of different experimental factors, such as adsorbent dosage, contact time, pH, drug concentration, temperature, ionic strength, presence of an external magnetic field (EMF), and magnet distance from the adsorption flask were optimized for the removal of COVID-19 drugs. The adsorption equilibrium isotherm proved that the adsorption process of DOX, HCQ, NAP, and DIP drugs on GO@Fe3O4@MIL-88@Alg hydrogel beads conformed to the Langmuir model and followed the pseudo-second-order adsorption kinetics. The maximum adsorption capacities of DOX, HCQ, NAP, and DIP drugs obtained for GO@Fe3O4@MIL-88@Alg hydrogel beads with the Langmuir model were 131.57, 79.92, 55.55, and 49.26 mg/g at 298 K, respectively. The thermodynamic study suggested a spontaneous endothermic adsorption process. Also, the conclusion from this study confirmed the validity of GO@Fe3O4@MIL-88@Alg hydrogel beads for excellent removal of COVID-19 drugs from water samples. It was also found that the GO@Fe3O4@MIL-88@Alg hydrogel beads could be reused with satisfactory removal efficiency in six cycles. Based on the study, the GO@Fe3O4@MIL-88@Alg hydrogel beads could be considered a sustainable, simple, economical, environmentally friendly absorption system for the removal of pharmaceutical contaminants from water.


Subject(s)
COVID-19 , Graphite , Metal-Organic Frameworks , Water Pollutants, Chemical , Humans , Hydrogels , Adsorption , Alginates , Pandemics , Doxycycline , Magnetic Fields , Water , Water Pollutants, Chemical/analysis , Kinetics , Hydrogen-Ion Concentration
3.
Colloids Surf B Biointerfaces ; 231: 113585, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37837689

ABSTRACT

In this study, a pH-responsive hydrogels based on laponite rapid dispersion (Lap®)/chitosan (CS)/polyvinyl alcohol (PVA) designed and was used for controlled delivery of the anticancer drug curcumin (CUR). First, it was accomplished by dissolving CUR in Lap® dispersion under the influence of the pH of the environment. Then, in the presence of Lap®CUR cross-linking was incorporated between CS and PVA polymers. The structural features of Lap®CUR/CS@PVA hydrogels are characterized using FT-IR, XRD, SEM/EDS, TEM, TGA, Zeta potential, and XPS. The in vitro drug release profiles confirmed a pH-responsive controlled release of CUR in acidic pH for all hydrogels. During 12 h, the cumulative release of CUR from Lap®CUR/0.1CS@PVA hydrogel was 27.9% and 12.3%, at pH 5.5 and 7.4, respectively. While during three days the release rate reached 48.5% and 18.5%. The CUR release kinetic from hydrogels also suggests that the kinetic data well fitted to the Korsmeyer-Peppas, diffusion-controlled and Fickian diffusion. Furthermore, in vitro cytotoxicity and DAPI staining study clearly illustrated that Lap®CUR/0.1CS@PVA hydrogel had lower cytotoxicity than CUR against MDA-MB 231 cancer cells, which confirmed the controlled release of drug through hydrogels. Meanwhile, in vitro hemolysis, antioxidant and antibacterial tests revealed that the prepared hydrogels have good blood compatibility, excellent antioxidant properties, and antibacterial activity. Based on the obtained results, the designed hydrogels could be potentially applied as pH-controlled drug delivery systems for cancer therapy.


Subject(s)
Breast Neoplasms , Chitosan , Curcumin , Humans , Female , Polyvinyl Alcohol/chemistry , Curcumin/chemistry , Delayed-Action Preparations , Chitosan/chemistry , Spectroscopy, Fourier Transform Infrared/methods , Antioxidants , Breast Neoplasms/drug therapy , Hydrogels/chemistry , Anti-Bacterial Agents/chemistry , Hydrogen-Ion Concentration , Drug Liberation , Drug Carriers/chemistry
4.
ACS Omega ; 8(37): 33202-33228, 2023 Sep 19.
Article in English | MEDLINE | ID: mdl-37744789

ABSTRACT

Diabetes mellitus is a prevalent chronic health condition that has caused millions of deaths worldwide. Monitoring blood glucose levels is crucial in diabetes management, aiding in clinical decision making and reducing the incidence of hypoglycemic episodes, thereby decreasing morbidity and mortality rates. Despite advancements in glucose monitoring (GM), the development of noninvasive, rapid, accurate, sensitive, selective, and stable systems for continuous monitoring remains a challenge. Addressing these challenges is critical to improving the clinical utility of GM technologies in diabetes management. In this concept, cyclodextrins (CDs) can be instrumental in the development of GM systems due to their high supramolecular recognition capabilities based on the host-guest interaction. The introduction of CDs into GM systems not only impacts the sensitivity, selectivity, and detection limit of the monitoring process but also improves biocompatibility and stability. These findings motivated the current review to provide a comprehensive summary of CD-based blood glucose sensors and their chemistry of glucose detection, efficiency, and accuracy. We categorize CD-based sensors into four groups based on their modification strategies, including CD-modified boronic acid, CD-modified mediators, CD-modified nanoparticles, and CD-modified functionalized polymers. These findings shed light on the potential of CD-based sensors as a promising tool for continuous GM in diabetes mellitus management.

5.
Int J Biol Macromol ; 242(Pt 1): 124739, 2023 Jul 01.
Article in English | MEDLINE | ID: mdl-37148933

ABSTRACT

In this study, the magnetite nanoparticles were immobilized on the sepiolite needles via co-precipitation of iron ions. Then, the resulted magnetic sepiolite (mSep) nanoparticles were coated with chitosan biopolymer (Chito) in the presence of citric acid (CA) to prepare mSep@Chito core-shell drug nanocarriers (NCs). TEM images showed magnetic Fe3O4 nanoparticles with small sizes (less than 25 nm) on the sepiolite needles. Sunitinib anticancer drug loading efficiencies were ⁓45 and 83.7 % for the NCs with low and high content of Chito, respectively. The in-vitro drug release results exhibited that the mSep@Chito NCs have a sustained release behavior with high pH-dependent properties. Cytotoxic results (MTT assay) showed that the sunitinib-loaded mSep@Chito2 NC had a significant cytotoxic effect on the MCF-7 cell lines. Also, the in-vitro compatibility of erythrocytes, physiological stability, biodegradability, and antibacterial and antioxidant activities of NCs was evaluated. The results showed that the synthesized NCs had excellent hemocompatibility, good antioxidant properties, and were sufficiently stable and biocompatible. Based on the antibacterial data, the minimal inhibitory concentration (MIC) values for mSep@Chito1, mSep@Chito2, and mSep@Chito3 were obtained as 125, 62.5, and 31.2 µg/mL towards S. aureus, respectively. All in all, the prepared NCs could be potentially used as a pH-triggered system for biomedical applications.


Subject(s)
Antineoplastic Agents , Chitosan , Magnetite Nanoparticles , Humans , Sunitinib , Drug Carriers , Citric Acid , Antioxidants , Staphylococcus aureus , Antineoplastic Agents/pharmacology , Antineoplastic Agents/therapeutic use , Magnetic Phenomena , Anti-Bacterial Agents/pharmacology , Hydrogen-Ion Concentration , Drug Liberation , Drug Delivery Systems
6.
Int J Biol Macromol ; 239: 124322, 2023 Jun 01.
Article in English | MEDLINE | ID: mdl-37019202

ABSTRACT

To develop a new more efficient colon cancer treatment bio-vehicle, in frontier research, for the first time, an attempt has been made to design a unique colon-targeted bio-carrier containing polysaccharides along with nanoporous materials. So, at first, an imine-based covalent organic framework (COF-OH) with respectively an average pore diameter and surface area at 8.5058 nm and 208.29 m2·g-1 was fabricated. In the next step, about 41.68 % and 95.8 % of 5-fluorouracil (5-Fu) and curcumin (CUR) respectively were loaded on COF-OH, and 5-Fu + CUR@COF-OH was achieved. Due to the higher rate of drug releases in simulated stomach media, 5-Fu + CUR@COF-OH was coated with a mixture of alginate (Alg) and carboxymethyl starch (CMS) via the ionic crosslinking (Alg/CMS@(5-Fu + CUR@COF-OH)). Findings displayed that the use of polysaccharide coat reduce the drug releases in simulated gastric and improved it in simulated intestinal and colonic fluids. The beads swelled about 93.33 % under simulated gastrointestinal conditions, but this value was found higher in the simulated colonic environment and reached 326.67 %. The hemolysis rate lower than 5 %, as well as the cell viability higher than 80 %, were the main showing signs of system biocompatibility. Altogether, the results of the preliminary investigations can highlight the potential of the Alg/CMS@(5-Fu + CUR@COF-OH) for colon-specific drug delivery.


Subject(s)
Colonic Neoplasms , Curcumin , Metal-Organic Frameworks , Humans , Alginates/therapeutic use , Colonic Neoplasms/drug therapy , Fluorouracil/pharmacology , Fluorouracil/therapeutic use , Curcumin/pharmacology , Curcumin/therapeutic use , Pharmaceutical Preparations , Excipients , Hydrogen-Ion Concentration , Drug Carriers/therapeutic use
7.
Int J Pharm ; 636: 122804, 2023 Apr 05.
Article in English | MEDLINE | ID: mdl-36889416

ABSTRACT

In this study, the Fe3O4 nanoparticles were encapsulated in the hyperbranched poly L-lysine citramid (HBPLC). The Fe3O4-HBPLC nanocomposite modified with L-arginine and quantum dots (QDs) to obtain Fe3O4-HBPLC-Arg/QDs as a new photoluminescent and magnetic nanocarrier for the pH-responsive release and targeted delivery of Doxorubicin (DOX). The prepared magnetic nanocarrier was fully characterized using different techniques. Its various potential as a magnetic nanocarrier was evaluated. The in-vitro drug release studies exhibited that the prepared nanocomposite has pH-responsive behavior. The antioxidant study revealed good antioxidant properties of the nanocarrier. Also, the nanocomposite revealed excellent photoluminescence with a quantum yield of 48.5 %. Cellular uptake studies showed that Fe3O4-HBPLC-Arg/QD has high cell uptake in MCF-7 cells and can be used for bioimaging applications. In-vitro cytotoxicity, colloidal stability, and enzymatic degradability studies revealed that the prepared nanocarrier is non-toxic (with cell viability of 94%), stabile and biodegradable (about 37%). The nanocarrier was hemocompatible with 8% hemolysis. Also, according to the apoptosis and MTT assays, the Fe3O4-HBPLC-Arg/QD-DOX induced greater toxicity and cellular apoptosis against breast cancer cells about 47.0 %.


Subject(s)
Drug Carriers , Nanocomposites , Humans , Drug Carriers/chemistry , Polymers , Amino Acids , Antioxidants , Drug Delivery Systems/methods , Doxorubicin/chemistry , MCF-7 Cells , Hydrogen-Ion Concentration , Drug Liberation
8.
Int J Pharm ; 634: 122675, 2023 Mar 05.
Article in English | MEDLINE | ID: mdl-36736967

ABSTRACT

Recently, metal-organic frameworks (MOFs) have attracted tremendous attention as promising porous drug delivery systems for cancer treatment. In this work, for the first time, a novel magnetic maltose disaccharide molecule modified with MIL-88 metal-organic framework (Fe3O4@C@MIL-88) was prepared, and then this targeted system was used for the delivery of the doxorubicin (DOX) drug. Eventually, Fe3O4@C@MIL-88-DOX were successfully decorated with folic acid conjugated chitosan (Fe3O4@C@MIL-88-DOX-FC) as a new targeted and controlled release drug system for treatment of MCF-7 breast cancer. The encapsulation efficiency of the DOX in the Fe3O4@C@MIL-88 was obtained at ∼83.6%. The in vitro drug release profiles showed a pH-responsive controlled release of DOX in acidic pH confirming the performance of the systems in the cancerous environment. The DOX release mechanism from systems at pH 5 also showed that the kinetic data well fitted to the Korsmeyer-Peppas and Fickian diffusion. Furthermore, in vitro cytotoxicity and DAPI staining study clearly illustrated that the synthesized Fe3O4@C@MIL-88 system had low cytotoxicity and good biocompatibility against MCF-7 cancer cells and MCF-10A normal cells. Whereas, Fe3O4@C@MIL-88-DOX and Fe3O4@C@MIL-88-DOX-FC exhibited good antitumor activity as a result of targeted delivery of DOX, which indicated the MCF-7 cell death with apoptotic effects. Based on these findings, the resulting carriers could be used as promising targeted drug delivery systems for cancer therapy.


Subject(s)
Chitosan , Metal-Organic Frameworks , Humans , Chitosan/chemistry , Metal-Organic Frameworks/chemistry , Maltose , Delayed-Action Preparations , Folic Acid/chemistry , Doxorubicin , Drug Delivery Systems/methods , Hydrogen-Ion Concentration , Magnetic Phenomena , Drug Carriers/chemistry
9.
Int J Biol Macromol ; 234: 123778, 2023 Apr 15.
Article in English | MEDLINE | ID: mdl-36822289

ABSTRACT

In recent years, the fabrication of new drug delivery systems (DDSs) based on functionalization by multi-component reactions (MCRs) has received special attention. In this regard, to obtain a new oral administration system for colon-specific cancer treatment, the CMC@MWCNTs@FCA carrier was designed and prepared from the functionalization of the CMC@MWCNTs as a biocompatible raw material with carboxamide group by the Ugi reaction. FT-IR analysis confirmed the successful synthesis of the product through the change in the functional groups of reagents. Additionally, the crystalline structure and porosity of the samples were studied by XRD and BET techniques. After a detailed characterization, the curcumin (CUR) was loaded on CMC@MWCNTs and CMC@MWCNTs@FCA, respectively, about 29 % and 38 %. In vitro drug release behavior studies for CUR-loaded CMC@MWCNTs@FCA showed the controlled release for it, so 11.6 % and 76.5 % of CUR, respectively were released at pH 1.2 and pH 7.4. Toxicological analysis displayed the IC50 of CMC@MWCNTs@FCA@CUR is 752 µg/mL. In conclusion, the obtained findings display that the fabricated system can be proposed as a biocompatible carrier for specific colon cancer treatment.


Subject(s)
Colonic Neoplasms , Curcumin , Nanotubes, Carbon , Humans , Curcumin/chemistry , Nanotubes, Carbon/chemistry , Carboxymethylcellulose Sodium , Spectroscopy, Fourier Transform Infrared , Drug Delivery Systems , Colonic Neoplasms/drug therapy , Drug Carriers/chemistry
10.
Int J Biol Macromol ; 221: 256-267, 2022 Nov 30.
Article in English | MEDLINE | ID: mdl-36067851

ABSTRACT

Herein, for the first time, the photoluminescent graphene quantum dots@Bio-metal organic framework (GQDs@Bio-MOF) nanohybrid was prepared. BET analysis obtained the average pore diameter of GQDs@Bio-MOF about 11.97 nm. The existence of nanoscale porosity in GQDs@Bio-MOF displays its suitability for 5-Fu loading owing to the smaller size of 5-Fu. 5-Fu entrapment efficiency and loading capacity were found to be ~42.04 % and ~4.20 %, respectively (5-Fu@GQDs@Bio-MOF). The 5-Fu@GQDs@Bio-MOF was capped with starch biopolymer (St@5-Fu@GQDs@Bio-MOF), fabricated sample displayed 4.67 for pHPZC. SEM analysis displayed that the St@5-Fu@GQDs@Bio-MOF microspheres have a spherical shape with a diameter of ~2 µm. The in vitro drug release assay displayed better release behavior for St@5-Fu@GQDs@Bio-MOF than 5-Fu@GQDs@Bio-MOF, releasing about 62.3 % of the entrapped 5-Fu within 96 h of incubation. The 5-Fu release showed the best fitting with the Higuchi model with R2 0.9884. The in vitro cytotoxicity screening outcomes displayed that the St@GQDs@Bio-MOF is a promising biocompatible carrier, with cell viability of higher than 84 %. Accumulation of the results revealed that the St@5-Fu@GQDs@Bio-MOF is a new system with advantages of sustained drug release and biocompatibility that are the main criteria for each newly designed anticancer drug carrier.


Subject(s)
Graphite , Metal-Organic Frameworks , Quantum Dots , Fluorouracil/pharmacology , Starch , Drug Liberation , Colon , Drug Delivery Systems
11.
Int J Pharm ; 625: 122112, 2022 Sep 25.
Article in English | MEDLINE | ID: mdl-35970281

ABSTRACT

Commonly the directly administered chemotherapy drugs lack targeting in tumor treatment. Thus, trying to improve cancer treatment efficiency led us to design a new intelligent system for cancer treatment. Considering these, in the current work, at first, the 2-aminoterephthalic acid (NH2-BDC) intercalated layered double hydroxides (MgAl-(NH2-BDC) LDH) were synthesized simply. Afterward, the in situ growth of the iron-based metal-organic frameworks in the presence of MgAl-(NH2-BDC) LDH occurred (MgAl-LDH/Fe-MOF). In the end, the reaction of MgAl-LDH/Fe-MOF with D-mannose (D-Man) achieved the MgAl-LDH/Fe-MOF/D-Man ternary hybrid nanostructure. Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analysis confirmed the formation of the monodisperse Fe-MOF with nanosize in the presence of MgAl-LDH. Importantly, methotrexate (MTX) and doxorubicin (DOX) entrapment efficiency reached respectively about 28 wt% and 21% for MgAl-LDH/Fe-MOF/D-Man. The in vitro drug release experiments revealed a higher drug release at pH 5.0 in comparison with pH 7.4 which revealed its promising potential for anticancer drug delivery applications. Bioassay results revealed that the co-drug-loaded MgAl-LDH/Fe-MOF/D-Man has higher cytotoxicity on MDA-MB 231 cells. At last, fluorescence microscopy and flow cytometric analysis confirmed the successful uptake of MgAl-LDH/Fe-MOF/D-Man into MDA-MB 231 cell lines, as well as its bioimaging potential. A survey in the published literature approved that this work is the first report on the evaluation of the MgAl-LDH/Fe-MOF/D-Man for targeted co-delivery of both MTX and DOX. Finally, results collectively demonstrate the importance of the biocompatible MgAl-LDH/Fe-MOF/D-Man as a hopeful candidate for biomedicinal applications from the targeted co-drug delivery and bioimaging potential viewpoints.


Subject(s)
Methotrexate , Nanocomposites , Doxorubicin/chemistry , Doxorubicin/pharmacology , Humans , Hydroxides/chemistry , Mannose , Methotrexate/chemistry , Nanocomposites/chemistry
12.
Int J Biol Macromol ; 205: 128-140, 2022 Apr 30.
Article in English | MEDLINE | ID: mdl-35181320

ABSTRACT

The release of antibiotic drugs into aquatic environments is a serious environmental and health problem in recent years. Therefore, the development of potential adsorbents for the effective removal of tetracycline (TC) and amoxicillin (AMX) of aqueous media is of great importance. In this study, new alginate beads were successfully prepared by encapsulation of Fe3O4@maltose-functionalized triazine dendrimer in alginate (Alg/Fe3O4@C@TD) for the first time. The obtained beads were utilized as a well adsorbent for the removal of TC and AMX antibiotics from aqueous solutions by batch adsorption procedure. The characteristics of the synthesized beads were investigated using FT-IR, Zeta potential, SEM, XRD, EDX, VSM, and BET. The effects of various operation factors such as adsorbent dose, pH of the solution, contact time, antibiotic initial concentration, temperature, and ionic strength on the removal of antibiotics were studied. Moreover, Langmuir and Freundlich adsorption isotherm results showed that the Langmuir model fitted well for the adsorption of both antibiotics onto Alg/Fe3O4@C@TD beads. Based on the Langmuir model, the maximum adsorption capacity of TC and AMX onto Alg/Fe3O4@C@TD beads at 25 °C was 454.54 and 400 mg/g, respectively. Kinetic and thermodynamic studies also indicated that the TC and AMX adsorption were found to be well fitted with a pseudo-second-order kinetic model, feasible, endothermic, and spontaneous in nature. In addition, the Alg/Fe3O4@C@TD beads showed excellent reusability for removal from both antibiotics after six adsorption cycles. Overall, the obtained results suggest that Alg/Fe3O4@C@TD beads could be considered as a low-cost and eco-friendly adsorbent for antibiotic contaminants removal from aquatic media.


Subject(s)
Tetracycline , Water Pollutants, Chemical , Adsorption , Alginates , Amoxicillin , Anti-Bacterial Agents , Hydrogen-Ion Concentration , Kinetics , Magnetic Phenomena , Spectroscopy, Fourier Transform Infrared
13.
Int J Biol Macromol ; 201: 193-202, 2022 Mar 15.
Article in English | MEDLINE | ID: mdl-35007629

ABSTRACT

Achieving a new oral drug delivery system with controlled drug release behavior is valuable in cancer therapy. Therefore, for the first time, doxorubicin (DOX) and 5-fluorouracil (5-Fu) were simultaneously co-loaded on the as-synthesized layered double hydroxides LDH(MgAl). The resulted system was encapsulated with carboxymethyl starch to improve its efficiency for colon cancer therapy. Several characterization techniques were used to evaluate the successful synthesis of the CMS@LDH(MgAl)@DOX,5-Fu microspheres. The scanning electron microscopy result showed that the size of prepared microspheres is about 72 µm. Additionally, the presence of one broad peak at 2θ ~ 20 of the X-ray diffraction spectrum approved its amorph nature. The drug release study showed a controlled release profile with ~22% of DOX and 29% of 5-Fu. In addition, the cell viability test outcome confirmed the sustained drug release pattern from CMS@LDH(MgAl)@DOX,5-Fu against the colon cancer cell line. The results suggest that the prepared microspheres are capable to operate as an acceptable formulation for oral co-drug delivery.


Subject(s)
Fluorouracil , Hydroxides , Doxorubicin/pharmacology , Drug Delivery Systems , Drug Liberation , Fluorouracil/chemistry , Hydroxides/chemistry , Starch/analogs & derivatives
14.
Int J Biol Macromol ; 200: 247-262, 2022 Mar 01.
Article in English | MEDLINE | ID: mdl-35007630

ABSTRACT

This work aimed to fabricate a new photoluminescent bionanogel with both targeted anticancer drug delivery and bioimaging potentials. Briefly, at first photoluminescent carbon dots (CDs) were synthesized from the low-cost and more available black pepper with traditional medicinal properties. The as-synthesized dialdehyde carboxymethyl cellulose (DCMC) was used as a safe crosslinker for gelatin crosslinking in the presence of CDs (CDs/DCMC-Gel). Eventually, the residual amine functional groups of gelatin were used for the conjugation of CDs/DCMC-Gel with folic acid (FA) ((CDs/DCMC-Gel)-FA bionanogels). All employed physicochemical characterization methods approved the (CDs/DCMC-Gel)-FA bionanogels fabrication route. SEM analysis specified the spherical morphology with a diameter of ~70-90 nm for it. Curcumin (CUR) and doxorubicin (DOX) respectively were loaded with drug entrapment efficiency of about 44.0% and 41.4%. The release rate for both drugs in acidic conditions was higher than in physiological conditions. In vitro antitumor experiments; MTT, DAPI staining, cellular uptake, and cell cycle tests showed the superior anticancer effect of the CUR@DOX@(CDs/DCMC-Gel)-FA in comparison with free CUR@DOX. Moreover, the (CDs/DCMC-Gel)-FA acted as a hopeful bio-imaging tool. Taken together, the designed (CDs/DCMC-Gel)-FA could be proposed as a promising nanosystem for efficient chemotherapy.


Subject(s)
Folic Acid
15.
Med Res Rev ; 42(2): 800-849, 2022 03.
Article in English | MEDLINE | ID: mdl-34693555

ABSTRACT

Nontoxic materials with natural origin are promising materials in the designing and preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted a great deal of attention because of its special features; green nature, biocompatibility, low price, biodegradability, and commercially available property. So, CA has been employed in the preparation of the various platforms to induce a suitable property on their structure. Recently, several research groups investigated the CA-based platforms in different forms like tablets, dendrimers, hyperbranched polymers, (co)polymer, hydrogels, and nanoparticles as efficient DDSs. By considering an increasing amount of published articles in this field, for the first time, in this review, an overview of the published works regarding CA applications in the design of various DDSs is presented with a detailed and insightful discussion.


Subject(s)
Citric Acid , Nanoparticles , Drug Delivery Systems , Humans , Hydrogels , Polymers
16.
Int J Biol Macromol ; 191: 531-539, 2021 Nov 30.
Article in English | MEDLINE | ID: mdl-34571120

ABSTRACT

Fabrication of porous materials with a high surface area affords a great interest to achieve a system with a prolonged drug release manner. In this context, the subject of this work is to describe a novel green one-pot synthesis route for the growth of metal-organic framework (MOF) from zinc metal (Zn) and 1, 4-benzene dicarboxylic acid (BDC) in the vicinity of the carboxymethyl cellulose (CMC), which homogeneously confined in the biopolymeric chains. The synthesized Zn (BDC)@CMC was characterized and confirmed using different analyses. N2 adsorption/desorption isotherms determined the mean diameter of pore size of about 2.3993 nm. Ibuprofen (IBU) as a model drug was highly loaded to the Zn(BDC)@CMC by immersing in the drug solution; 50.95%. The in vitro IBU release study indicated that the Zn(BDC)@CMC has more attractive performances than pristine Zn(BDC). The IBU release occurred via the Fickian mechanism. Isotherm studies showed that the IBU adsorption on obeys from Langmuir isotherm; R2 0.9623. The MTT results revealed the HEK 293A cell viability of higher than 90% for Zn(BDC)@CMC that confirms its cytocompatibility. Overall, obtained results confirm the functionality of CMC biopolymer for in situ growth of MOF in the presence of it due to having the reactive nature.


Subject(s)
Carboxymethylcellulose Sodium/chemistry , Drug Carriers/chemical synthesis , Metal-Organic Frameworks/chemical synthesis , Zinc/chemistry , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Cell Survival/drug effects , Drug Carriers/toxicity , HEK293 Cells , Humans , Ibuprofen/administration & dosage , Metal-Organic Frameworks/toxicity
17.
Int J Biol Macromol ; 191: 108-117, 2021 Nov 30.
Article in English | MEDLINE | ID: mdl-34537293

ABSTRACT

In this work, for the first time, a new magnetic cadmium-based MOFs (Fe3O4@Cd-MOF) was successfully synthesized in a green way and then modified with chitosan (CS) in the microsphere form (Fe3O4@Cd-MOF@CS). The obtained materials were fully characterized by several techniques. In the following, the efficiency of Fe3O4@Cd-MOF@CS was explored for the removal of amoxicillin (AMX). The outcome of the adsorption study showed that the removal efficiency is affected by CS and reaches its optimum at pH 8 and contact time of 240 min. Under optimized conditions, over 75% of AMX was removed. The kinetic and the isotherm of the adsorption were fit with the pseudo-second-order model and the Langmuir adsorption isotherm respectively. Eventually, the maximum adsorption capacity was obtained ~103.09 mg/g. Interestingly, these findings convince that the newly prepared Fe3O4@Cd-MOF@CS could be proposed as a promising magnetically separable adsorbent for antibiotic contaminants removal from the aqueous solution.


Subject(s)
Amoxicillin/chemistry , Anti-Bacterial Agents/chemistry , Ferric Compounds/chemistry , Metal-Organic Frameworks/chemistry , Microspheres , Water Purification/methods , Adsorption , Amoxicillin/analysis , Anti-Bacterial Agents/analysis
18.
Carbohydr Polym ; 258: 117654, 2021 Apr 15.
Article in English | MEDLINE | ID: mdl-33593542

ABSTRACT

Conventional drug administrations are associated with low bioavailability, high cost, more side effects, uncontrolled release profile, and patient noncompliance. Therefore, the development of an alternative to traditional drug delivery systems (DDSs) is of crucial significance. Up to now, various materials have been investigated for these purposes, among them, carboxymethyl starch (CMS) owing to its specific advantages has been studied for extensively drug delivery, particularly for oral administration. This review for the first time provides an outline of the CMS application in all areas of drug delivery. Thus, the major focus of this review is the detailed highlighting of the recent advances in CMS based DDSs to offer comprehensive information for overcoming traditional DDSs. The perspectives and the challenges of the CMS-based DDSs are briefly commented as well as. Hopefully, the current review will help to promotion of new innovative types of CMS-based systems for drug delivery applications in the near future.


Subject(s)
Administration, Oral , Chemistry, Pharmaceutical/trends , Drug Carriers , Drug Delivery Systems , Starch/analogs & derivatives , Biocompatible Materials/chemistry , Biological Availability , Chemistry, Pharmaceutical/methods , Humans , Hydrogen-Ion Concentration , Inorganic Chemicals , Nanoparticles/chemistry , Pharmaceutical Preparations , Polymers/chemistry , Solubility , Starch/chemistry , Tablets , Water/chemistry
19.
RSC Adv ; 11(38): 23574-23588, 2021 Jul 01.
Article in English | MEDLINE | ID: mdl-35479775

ABSTRACT

This article describes the synthesis and properties of novel imidazole-based aromatic polyimides (PIs) containing bulky groups from direct polycondensation of two diamines with 3,3',4,4'-benzophenone tetracarboxylic dianhydride (BTDA) and (hexafluoroisopropylidene)diphthalic anhydride (6FDA). The structure-property relationship of the prepared samples was fully determined via FT-IR, 1H and 13C NMR and elemental analysis (CHN) techniques. The inherent viscosity values of the polyimides ranged from 0.51 to 0.73 dL g-1. These PIs showed glass transition temperatures ranging from 273 to 306 °C, and 10% mass loss temperatures within the range of 478-504 °C in a N2 atmosphere. High transparency with a UV-visible absorption cut-off wavelength was found to range between 285 and 300 nm. Good antimicrobial activity can be correlated with the presence of xanthene and imidazole units into the main structure of PIs. Next, SiO2 nanoparticles as inorganic nanoparticles were added to one of the synthesized polyimides (BTDA-PIb), causing changes in the attributes of both the nanoparticles and PI. The data obtained from examining the properties of the prepared BTDA-PIb/HBP@SiO2 demonstrated increased heat resistance, photoluminescence intensity, and antimicrobial inhibition compared to pure PI. Also, in this article, the polymeric samples as adsorbents were evaluated for extraction of heavy metal ions (Hg2+ and Co2+) from water sources.

20.
Int J Biol Macromol ; 164: 2301-2311, 2020 Dec 01.
Article in English | MEDLINE | ID: mdl-32805288

ABSTRACT

Biocompatible drug delivery vehicles with sustained drug release property are valuable in cancer therapy and can reduce some of the side effects. Hence, to achieve the biocompatible system with sustained drug release behavior a new drug carrier was fabricated via in situ synthesis of MIL-53 (MIL = Materials of Institute Lavoisier) within the carboxymethylcellulose/graphene quantum dots matrix (CMC/GQDs) as a biological macromolecule based platform (MIL-53@CMC/GQDs). Fourier transform infrared (FT-IR), and X-ray diffraction (XRD) analysis revealed successful synthesis of MIL-53@CMC/GQDs. The mean pore diameter of MIL-53@CMC/GQDs obtained 18.66 nm. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) exhibited that MIL-53 is well distributed in hydrogel matrix. Doxorubicin (DOX) was loaded about 55.80% and 88.90% into the MIL-53 and MIL-53@CMC/GQDs, respectively. Drug release studies showed the pH-dependent DOX release behavior for DOX@MIL-53@CMC/GQDs. The cytotoxic assay approved the biocompatibility of MIL-53@CMC/GQDs against the human breast cancer cell line (MDA-MB 231). The fragmentation of nuclei and condensation of chromatin after treatment with DOX@MIL-53@CMC/GQDs displayed its capability in cancer treatment. Moreover, an arrest in sub-G1 of cell cycle after treatment with MIL-53@CMC/GQDs showed cell's apoptosis. The results conveyed a new concept that the MIL-53@CMC/GQDs could be proposed as a potential carrier for the delivery.


Subject(s)
Antineoplastic Agents/chemistry , Carboxymethylcellulose Sodium/chemistry , Drug Carriers/chemistry , Graphite/chemistry , Metal-Organic Frameworks/chemistry , Quantum Dots/chemistry , Antineoplastic Agents/pharmacology , Apoptosis/drug effects , Breast Neoplasms/drug therapy , Cell Line, Tumor , Delayed-Action Preparations/chemistry , Delayed-Action Preparations/pharmacology , Doxorubicin/chemistry , Doxorubicin/pharmacology , Drug Delivery Systems/methods , Drug Liberation/physiology , Female , Humans , Hydrogels/chemistry , Nanocomposites/chemistry , Spectroscopy, Fourier Transform Infrared/methods
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