Response of plastic scintillator to gamma sources.

In this study, we developed a method for directly determining the energy deposited over the entire energy range by monitoring the light output from a plastic scintillator under gamma irradiation. The relative light output was analyzed based on Birks' semi-empirical formula for ionization to obtain the quenching parameter as kB = 0.016 ± 0.0004 g cm-2 MeV-1. Comparisons of experimental and calculated results for the light output spectra showed that considering the quenching effect, background subtraction, source casing, and energy sampling were essential for achieving good agreement.

PHOTON FIELD OF ~100-200 KEV FOR ENVIRONMENTAL DOSEMETER CALIBRATION.

As a reference photon field, several radionuclides have been used frequently, such as 241Am,137Cs and60 Co for calibration. These nuclides provide mono-energy photons for dosemeters covering few tens of keV-MeV. The main energy around 200 keV is important for both environmental and medical fields since the former should consider scattering photons and the later should measure photons from X-ray generator. In our previous work, a backscattered layout can provide a uniform photon field spectra and dose rate with an energy of 190 keV by using an affordable intensity 137 Cs gamma source. Several other quasi-monoenergetic photon fields in the range of 100-200 keV could be obtained by using several available gamma sources. Two calibrated environmental CsI(Tl) survey meters, Horiba PA-1000 and Mr. Gamma A2700, had been measured with the developed backscattered photon field to understand energy-dependent features in order to confirm dosemeter readings. Consequently, both scintillator instruments are sensitive for measurements of the relatively low dose rates at 190 keV.

Analysis of the effect of structural materials in a wall-less tissue-equivalent proportional counter irradiated by 290 MeV u(-1) carbon beam.

Effects of structural materials in a wall-less tissue-equivalent proportional counter were evaluated based on the calculation of energy deposits by EGS5 and the measurement of lineal energy distributions using 290 MeV u(-1) carbon beams. It is found that the correction of measured data based on simulation is necessary for understanding the energy deposition spectra in the homogeneous condition in tissues.

Response of GafChromic MD-55 radiochromic film to synchrotron radiation.

Synchrotron radiation has been increasingly and extensively used for materials science, biology and medical research. For measurement of high dose from the low energy photons, tissue-equivalent dosemeters having linearity in the Gy region are required. In this study, energy and dose responses of double-layer Gafchromic film MD-55 were measured using 10-40 keV monoenergetic photons from synchrotron radiation. The result showed that the energy responses normalised at 60Co gamma rays were 0.58-0.59 at 10-20 keV, 0.66 at 30 keV and 0.72 at 40 keV in air. The linearity was confirmed to extend from 2 Gy to 100 Gy.

Dose measurements in inhomogeneous bone/tissue and lung/tissue phantoms for angiography using synchrotron radiation.

For angiography using synchrotron radiation we measured the absorbed dose distribution in inhomogeneous phantoms with thin LiF:Mg, Cu, P, LiF:Mg, Ti thermoluminescent dosimeters (TLDs) in tissue and lung substitutes, and with Mg2SiO4:Tb TLDs in bone substitute for 33.32 keV monoenergetic photons from synchrotron radiation. The energy responses of the TLDs were measured in air for 10-40 keV monoenergetic photons. The values at 30 keV became smaller by 30% for LiF:Mg, Cu, P and larger by 22% for Mg2SiO4:Tb than the ratio of the mass energy absorption coefficients of the TLDs to that of air. These values were used to modify the calculated response of the TLDs in each phantom material. The absorbed dose distribution obtained was compared with that calculated using the Monte Carlo transport code EGS4 expanded to a low-energy region, and their agreement was confirmed taking linear polarization into account. In the bone substitute the dose increased by a factor of 3.9, while behind the bone the dose decreased drastically because of photon attenuation. In the lung substitute a slight dose difference from that in soft tissue was observed because of its different density. The LiF:Mg, Cu, P TLDs exhibited a better energy response, higher sensitivity and wider linear regions than did the other tissue-equivalent TLDs in the low-energy region.

Comparison of in-phantom dose distributions for coronary angiography using an x-ray machine and synchrotron radiation.

Coronary cineangiography using synchrotron radiation is anticipated, owing to the high intensity and availability of monoenergy. To investigate allowable dose levels in clinical application, absorbed dose distribution in a tissue substitute phantom for a conventional x-ray machine was measured with thermoluminescent dosimeters at the University of Tsukuba under the practical conditions used for digital angiography. The dose rate at a 0.5-cm depth was 0.145 Gy/s, and the dose per frame was 0.725 mGy for the irradiation period of 5 ms per frame. For synchrotron radiation, the dose distribution measurement was made at a 5-GeV AR (Accumulation Ring) of the High Energy Accelerator Research Organization, in which a polymethylmethacrylate (PMMA) phantom was irradiated with the strongest beam available at the facility, which was 33.32 keV, 5.2 x 6.2 cm2 beam. Using this beam, a 1-mm-diameter coronary artery has been visualized at 1% iodine concentration at the AR. Nonhomogeneous strength distribution in the beam was observed in the vertical direction. The maximum dose rate was 0.556 Gy/s, and it attenuated to 1/3000 at a 30-cm depth in the beam center. At the deep positions, the doses were influenced by the high harmonics, which was confirmed with an EGS4 Monte Carlo calculation. Outside the beam, beam contamination on both sides of the main beam affected the doses. For comparison to the x-ray machine, the measured dose was analytically converted to that needed for a 5.2 x 16 cm2 beam that is used for clinical application. The dose rate at 0.5-cm depth was found to be 0.215 Gy/s, which is 1.48 times larger than that for x-rays. Moreover, the attenuation rate in the phantom was significantly greater than that of the x-ray machine, because of the difference of the energy spectra between the x-rays and synchrotron radiation used.

Monte Carlo simulation of dose distributions from a synchrotron-produced microplanar beam array using the EGS4 code system.

Microbeam therapy is established as a general concept for brain tumour treatment. A synchrotron based x-ray source was chosen for experimental research into microbeam therapy, and therefore new simulations were essential for investigating the therapy parameters with a proper description of the synchrotron radiation characteristics. To design therapy parameters for tumour treatments, the newly upgraded LSCAT (Low energy SCATtering) package of the EGS4 Monte Carlo simulation code was adapted to develop an accurate self-written user code for calculating microbeam radiation dose profiles with a precision of 1 microm. LSCAT is highly suited to this purpose due to its ability to simulate low-energy x-ray transport with detailed photon interactions (including bound electron incoherent scattering functions, and linear polarized coherent scattering). The properties of the synchrotron x-ray microbeam, including its polarization, source spectrum and beam penumbra, were simulated by the new user codes. Two concentric spheres, an inner sphere, defined as a brain, and a surrounding sphere, defined as a skull, represented the phantom. The microbeam simulation was tested using a 3 x 3 cm array beam for small treatment areas and a 6 x 6 cm array for larger ones, with different therapy parameters, such as beam width and spacing. The results showed that the microbeam array retained an adequate peak-to-valley ratio, of five times at least, at tissue depths suitable for radiation therapy. Dose measurements taken at 1 microm resolution with an 'edge-on' MOSFET validated the basics of the user code for microplanar radiation therapy.

Monte Carlo modelling of radiotherapy kV x-ray units.

To obtain accurate information for absorbed dose calculations in water for kilovoltage x-rays, the photon spectrum, planar fluence and the angular distribution of the photons at the collimator exit of the x-ray unit have to be known. The only way to obtain this information is by Monte Carlo (MC) simulation. Compared with the situation for high-energy photons and electrons, where in recent years numerous papers have been devoted to MC modelling of complete clinical accelerator units, there is a lack of similar work for kV x-ray units. A reliable MC model for a kV x-ray unit would allow the output information to be used in a treatment planning system for regular and irregular treatment fields. Furthermore, with MC simulation, perturbation factors of dose-measuring devices, such as those specified in codes of practice, can be calculated. In this work, the MC code EGS4/BEAM was used to build realistic models of two complete x-ray units. The tungsten target, exit window, collimator, additional filtration and applicator were taken into account. For some aspects of the work, a comparison was made with the simulations from another MC code, MCNP4B. The contribution to the characteristic radiation from electron impact ionization and from the photoelectric effect of reabsorbed bremsstrahlung photons was studied. Calculated and measured photon fluence spectra in air and half-value layers for a Philips MCN410 tube were compared for several anode voltages and additional filtrations. Results from the two codes agreed well, and the agreement with measured spectra was found to be good for energies above 50 keV but rather less good below that energy. For a Siemens Stabilipan 2 Th300 x-ray tube, HVLs and dose distributions in water were compared with measurements for several clinical x-ray qualities. For most of the combinations of radiation qualities and applicators, good agreement was obtained, although there were also some cases where the agreement was not so good. Electron contamination and photon build-up at the water surface were studied using MC simulation. The influence of depth on the photon spectral distribution was investigated. Both EGS4/BEAM and MCNP4B, in their default versions, handle inadequately the production of characteristic x-rays. This was found to have only a minor influence on the calculated dosimetric quantities. Simulations with MCNP4B required the use of several variance reduction techniques in order to obtain results within reasonable calculation times.

Absorbed dose measurements and calculations in phantoms for 1.5 to 50 keV photons.

A Monte Carlo code EGS4 expanded for low energy photon transport was validated by measuring absorbed doses in a phantom for 30 and 10 keV monoenergetic photons from synchrotron radiation. Using the EGS4 code, depth doses at 0.07 mm, 0.02 to 0.1 mm, and 10 mm in the ICRU slab phantoms were calculated for 1.5 to 50 keV photons using the updated photon cross section data PHOTX. The results show that the doses at 0.02 to 0.1 mm below 10 keV are practical indices of effective dose as calculated by others, based on the 1990 ICRP recommendations (1991).