ABSTRACT
BACKGROUND: To discuss the experience of diagnosis and treatment of ovarian cyst in infants. MATERIALS AND METHODS: A retrospective review was conducted on 20 infants who suffered from ovarian cyst. RESULTS: There were no dysplasia ovarian was found in children which were preoperatively diagnosed simplex cyst. Within thirteen children preoperatively detected mixed cystic-solid lesion, six cases ovarian cysts disappeared and two cases underwent poor blood supply in the following time. CONCLUSION: Adverse effects for ovarian cyst in infants can be prevented by agressive surgical intervention. Harmful effects of ovarian cyst can be prevented by positive surgical intervention despite the diagnostic difficulties in children with clinical symptoms of this condition.
ABSTRACT
Objective: To study the chemical constituents of the ethyl acetate (EtOAc) extract from Zanthoxylum avicennae and their bioactivities. Methods: The compounds were isolated by Diaion HP-20, Toyopearl HW-40, MCI-Gel CHP-20, Sephadex LH-20, RP18, and silica gel column chromatographic methods. Their structures were identified on the basis of physicochemical and spectroscopic analyses; The antibacterial activity and toxicity of compounds 1-3 were investigated by the lethal-to-prawn larva bioactivity experiment and the slanting test-tube experiment. Results: Nine constituents were isolated from the EtOAc and n-BuOH fractions of Z. avicennae. Their structures were identified as dihydrokaempferide (1), scoparone (2), 1H-indole-3-carboxylic acid (3), 6-oxo-2(4-hydroxy-3,5-dimethoxyphenyl)-3,7-dioxabicyclo-[3.3.0]-octane (4), suberic acid (5), 4,4-dinethyl-1,7-heptanedioic acid (6), methyl syringate (7), β-sitosterol (8), and preskimmianine (9). Compound 2 displayed more stronger antifungal activity against Exserohilum turcicum Pass and Fusarium graminearum Schwabe, with the MIC value of 15.63 μg/mL. Compounds 1-3 had shown more stronger toxicity towards brine shrimp, with LC50 values of 9.8, 2.6, and 4.9 μg/mL, respectively. Conclusion: All the compounds are isolated from Z. avicennae for the first time except preskimmianine. Compound 2 displays more stronger antifungal activity, while compounds 1-3 have shown more stronger cytotoxicity towards brine shrimp.
ABSTRACT
OBJECTIVE: To review the applications of D-α-tocopherol polyethylene glycol succinate (TPGS) as a drug carrier in pharmaceutical preparation.
