ABSTRACT
Two new iridoid glycosides (1 and 2), together with the known compounds barlerin (3) and verbascoside (4), were isolated from Barleria prionitis. The new iridoid glycosides were determined to be 6-O-trans-p-coumaroyl-8-O-acetylshanzhiside methyl ester (1) and its cis isomer (2) by using spectroscopic, especially 2D NMR, data. A 3:1 mixture of 1 and 2 was shown to have potent in vitro activity against respiratory syncytial virus (EC50 2.46 microgram/mL, IC50 42.2 microgram/mL).
Subject(s)
Antiviral Agents/isolation & purification , Glycosides/isolation & purification , Plants, Medicinal/chemistry , Respiratory Syncytial Viruses/drug effects , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Cytopathogenic Effect, Viral , Glycosides/chemistry , Glycosides/pharmacology , Magnetic Resonance Spectroscopy , ThailandABSTRACT
Two new lignans, rhinacanthin E (1) and rhinacanthin F (2), were isolated from the aerial parts of the plant Rhinacanthus nasutus. Their structures were established by detailed spectroscopic analysis. These compounds show significant antiviral activity against influenza virus type A.
Subject(s)
Antiviral Agents/isolation & purification , Influenza A virus/drug effects , Lignans/isolation & purification , Plants, Medicinal/chemistry , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/isolation & purification , Antineoplastic Agents, Phytogenic/pharmacology , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Drug Screening Assays, Antitumor , Lignans/chemistry , Lignans/pharmacology , Magnetic Resonance Spectroscopy , Mass Spectrometry , Plant Leaves/chemistry , Spectrophotometry, Ultraviolet , Thailand , Viral Plaque AssayABSTRACT
Two new naphthoquinones, rhinacanthin-C (1) and rhinacanthin-D (2), exhibit inhibitory activity against cytomegalovirus (CMV), with EC50 values of 0.02 and 0.22 microgram/mL, respectively, against human CMV. They were isolated from the medicinal plant Rhinacanthus nasutus (Acanthaceae). The structures of the compounds were determined by analysis of their spectroscopic data, in particular, 2D NMR.
Subject(s)
Antiviral Agents/isolation & purification , Cytomegalovirus/drug effects , Naphthoquinones/isolation & purification , Plants, Medicinal , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Chemical Fractionation , Humans , Lethal Dose 50 , Magnetic Resonance Spectroscopy , Mass Spectrometry , Naphthoquinones/chemistry , Naphthoquinones/pharmacology , Plant Extracts/chemistry , Plant Extracts/isolation & purification , Plant Extracts/pharmacologyABSTRACT
Curcuma comosa is a member of the economically important plant family, Zingiberaceae. A methanolic extract of C. comosa was shown to be nematocidal when tested against the free-living nematode Caenorhabditis elegans. Five diphenylheptanoids [1-5], one new and four known, have been isolated and shown to be responsible for the activity. This is the first report of three of these compounds [1, 2, 4] being isolated from a natural source.
