ABSTRACT
Five acute schizophrenic patients were given a standard thioridazine dose (4 mg/kg/day po). Their plasma concentrations of thioridazine and its metabolites were determined by GLC, and their ECG's were recorded routinely. In four of the five patients, abnormal ECG's (malformation of the T-wave or lengthening of the repolarization time) were found whenever plasma concentrations of the thioridazine ring sulfoxide were elevated. No relationship could be detected between the appearance of ECG abnormalities and the concentrations of thioridazine and its other metabolites.
Subject(s)
Electrocardiography , Thioridazine/blood , Adult , Biotransformation , Humans , Kinetics , Middle Aged , Schizophrenia/blood , Schizophrenia/physiopathology , Thioridazine/adverse effectsSubject(s)
Thioridazine/blood , Biotransformation , Chromatography, Gas , Humans , Mesoridazine/blood , Spectrometry, Fluorescence , Time FactorsABSTRACT
A GLC method for measuring thioridazine, mesoridazine, their metabolites, and possibly other phenothiazines was developed. By using this method, seven different phenothiazine derivatives, thioridazine, and six known thioridazine metabolites were extracted and separated. This method was tested by assaying plasma samples from 30 hospitalized psychiatric patients receiving thioridazine or mesoridazine.
