[Remineralization effect of casein phosphopeptide-amorphous calcium phosphate for enamel demineralization: a system review].

OBJECTIVE: This study  aims  to  assess  the  remineralization effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP) on enamel demineralization by  performing  system review of  randomized  controlled  trials (RCT)  involving  the  treatment of enamel demineralization with  CPP-ACP. METHODS: The  study  was  developed  based  on  the 
Cochrane handbook  for  systematic  reviews of  interventions (Version 5.1.0) and included  the  following: search  strategy, selection  criteria, data  extraction, and  risk  of  bias  assessment. We  searched electronic  databases  such  as  PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP up  to  September  2016. RCT of  treating  enamel demineralization with  CPP-ACP were  included. Data  extraction  and  domain-based  risk  of  bias  assessment  were independently  performed  by  two  reviewers. RESULTS: Twelve  RCTs  were  included.  Because of the difference of experimental design and evaluation standards, the quantitative analysis can not be carried out. CONCLUSIONS: There is no strong evidence that CPP-ACP is superior to conventional fluoride formulations in enamel remineralization. However, due  to the limitations of sample size, follow-up time and study design,  more high quality and large-sample RCT are needed to  further  verify  the evidence.

Remineralization effect of casein phosphopeptide-amorphous calcium phosphate for enamel demineralization: a system review / 华西口腔医学杂志

<p><b>OBJECTIVE</b>This study  aims  to  assess  the  remineralization effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP) on enamel demineralization by  performing  system review of  randomized  controlled  trials (RCT)  involving  the  treatment of enamel demineralization with  CPP-ACP.</p><p><b>METHODS</b>The  study  was  developed  based  on  the 
Cochrane handbook  for  systematic  reviews of  interventions (Version 5.1.0) and included  the  following: search  strategy, selection  criteria, data  extraction, and  risk  of  bias  assessment. We  searched electronic  databases  such  as  PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP up  to  September  2016. RCT of  treating  enamel demineralization with  CPP-ACP were  included. Data  extraction  and  domain-based  risk  of  bias  assessment  were independently  performed  by  two  reviewers.</p><p><b>RESULTS</b>Twelve  RCTs  were  included.  Because of the difference of experimental design and evaluation standards, the quantitative analysis can not be carried out.</p><p><b>CONCLUSIONS</b>There is no strong evidence that CPP-ACP is superior to conventional fluoride formulations in enamel remineralization. However, due  to the limitations of sample size, follow-up time and study design,  more high quality and large-sample RCT are needed to  further  verify  the evidence.</p>

[Research progress on the cellular and molecular mechanisms of tooth eruption].

Tooth eruption is a series of complicated physiological processes occurring once the crown is formed completely, as well as when the tooth moves toward the occasion plane. As such, the tooth moves through the alveolar bone and the oral mucosa until it finally reaches its functional position. Most studies indicate that the process of tooth eruption involves the alveolar bone, dental follicles, osteoclasts, osteoblasts, and multiple cytokines. Dental follicles regulate both resorption and formation of the alveolar bone, which is required for tooth eruption. Furthermore, root formation with periodontal ligament facilitates continuous tooth eruption. However, the exact mechanism underlying tooth eruption remains unclear. Hence, this review describes the recent research progress on the cellular and molecular mechanisms of tooth eruption.

Orthodontists' and laypeople's perception of smile height aesthetics in relation to varying degrees of transverse cant of anterior teeth.

AIMS: To determine the effect of varying the transverse cant of the anterior teeth on orthodontists' and laypeople's perceptions of smile aesthetics, and the influence that smile height has on this perception. MATERIALS AND METHODS: A 20-year-old Chinese female with an aesthetic smile and normal occlusion was chosen and agreed to participate. Digital pictures of her posed smile were taken and manipulated to create three smile height variations: low, medium, or high. Each variation was further manipulated to create varying degrees of transverse anterior tooth cant. Fifty-six laypeople and 40 orthodontists participated as raters of the dental and facial impact of the altered smile images. RESULTS: The orthodontists more commonly and precisely identified the transverse cants of the anterior teeth and the detracting influence on smile aesthetics compared with laypersons. The orthodontists accepted a lesser range of anterior transverse cant. Increased smile heights enhanced the capability of all raters to detect a transverse cant and reduced the acceptable cant range. In addition, an increased smile height worsened the detracting effects of the transverse anterior cant in all raters' perceptions of smile aesthetics. An increased display of teeth and angulation of an anterior cant increased the ability of raters in both groups to detect differences. CONCLUSION: Transverse cants of anterior teeth can affect orthodontists' and laypeople's perceptions of smile aesthetics. Smile height and incisor display were significant factors that affected the orthodontist's and layperson's perceptions of smile aesthetics, and suggested that a description of the detracting effect of an anterior transverse cant should also consider smile height. CLINICAL RELEVANCE: A transverse occlusal cant is an important aesthetic factor used by clinicians during orthodontic diagnosis and review. It is important to appreciate that there is a difference in perception between orthodontic professionals and patients (laypeople). The extent of this perceptual difference and influencing factors could help the clinician set more appropriate treatment goals.

Skeletal Class Ⅲ patients treated with Fränkel function regulator type Ⅲ in the early and late mixed dentition / 中华口腔医学杂志

<p><b>OBJECTIVE</b>To investigate the outcome of skeletal Class Ⅲ patients treated with Fränkel function regulator type Ⅲ (FR Ⅲ)in the early mixed and late mixed dentition.</p><p><b>METHODS</b>The samples consisted of 45 mild and moderate skeletal Class Ⅲ patients(26 males, 19 females; meanage, [7.9±1.3] years) treated with FR Ⅲ. According to Hellman's dental developmental stages, these samples were divided into early-treated group(n=24) and late-treated group(n=21). Lateral cephalograms were taken at the beginning and the end of treatment. Twenty-one measurements on hard and soft tissue were included.</p><p><b>RESULTS</b>After treatment, SNA, ANB, NA-Apo, Wits, U1-SN, U1-NA, Overjet, UL-EP were significantly increased (1.0±1.9)°, (1.2±1.6)°, (2.6±4.2)°, (1.8±2.7) mm, (4.2±7.6)°, (2.6±7.5)°, (3.6±2.3) mm and (0.8±2.2) mm(P<0.05). OP-SN and IMPA were significantly decreased (1.5±3.7)°and (1.4±4.2)°(P<0.05). There were significant differences in SNA, ANB, UL-EP, IMPA, L1-NB between early-treated group and late-treated group(P<0.05).</p><p><b>CONCLUSIONS</b>FR Ⅲ was suitable for the treatment of mild and moderate skeletal Class Ⅲ patients. The result was better in the early-treated patients than in late-treated ones.</p>

Research progress on the cellular and molecular mechanisms of tooth eruption / 华西口腔医学杂志

Tooth eruption is a series of complicated physiological processes occurring once the crown is formed completely, as well as when the tooth moves toward the occasion plane. As such, the tooth moves through the alveolar bone and the oral mucosa until it finally reaches its functional position. Most studies indicate that the process of tooth eruption involves the alveolar bone, dental follicles, osteoclasts, osteoblasts, and multiple cytokines. Dental follicles regulate both resorption and formation of the alveolar bone, which is required for tooth eruption. Furthermore, root formation with periodontal ligament facilitates continuous tooth eruption. However, the exact mechanism underlying tooth eruption remains unclear. Hence, this review describes the recent research progress on the cellular and molecular mechanisms of tooth eruption.