[The characteristics of the development of immunity with a primary immunization complex using adsorbed DTP vaccine]. / Osobennosti formirovaniia immuniteta pri pervichnom komplekse immunizatsii AKDS-vaktsinoi.

The intensity of immunity, depending on immune response variants characterized by the definite composition of the T and B lymphocyte subpopulation in peripheral blood, was studied in 70 practically healthy young children after the primary complex of immunization with adsorbed DPT vaccine. The most stable immune reaction was shown to appear in children with the hyperergic and normoergic variants of immune response to diphtheria and tetanus toxoids, while the reaction to pertussis antigen was essentially weaker both after the second vaccination and after the first revaccination. In children with the hypoergic variant of immune response to all components of adsorbed DPT vaccine the resulting immune reaction was 2.5-3 times weaker than in children of other groups.

[The effect of fenibut on the ultrastructure of the brain mitochondria in traumatic edema and swelling]. / Vliianie fenibuta na ul'trastrukturu mitokhondrii mozga pri travmaticheskom oteke-nabukhanii.

Rat experiments using electron microscopy have established that profound destructive changes occur in the mitochondria in the intra- and perifocal traumatic area in dynamics of traumatic edema-swelling. With phenibut, 50 mg/kg, there is an increase in the number of mitochondria in the brain tissue of the perifocal area, their destructive changes are less pronounced. It is assumed that the positive effect of phenibut on brain bioenergetic processes in the posttraumatic period is associated with the changes.

[Specifics of endocrine regulation of digestion in patients with esophageal neoplasms after esophagogastroplasty]. / Osobennosti éndokrinnoi reguliatsii pishchevareniia u bolnykh rakom pishchevoda posle ézofagogastroplastiki.

In 67 patients with esophageal cancer, the peculiarities of endocrine regulation of alimentation after resection and plasty of the esophagus, using an isoperistaltic gastric tube were studied. Of these patients, 15 underwent correction of the disorders revealed. Accelerated evacuation of the content from a gastric transplant is accompanied by atony of the pylorus and is due to relative incompetence of neuroendocrine elements in gastric and duodenal mucosa (presence of a small amount of EC- and P-cells). Use of pentagastrin at the early postoperative period permits to accelerate the process of formation of the compensatory-adjusting mechanisms in the system of alimentation due to increase in functional activity of EC- and I-cells.

[Characteristics of the morphologic changes in an experimental suppurative wound of the perimandibular soft tissues treated by some types of laser radiation]. / Osobennosti morfologicheskikh izmenenii v gnoinoi rane okolocheliustnykh miagkikh tkanei v éksperimente pri lechenii nekotorymi vidami lazernogo izlucheniia.

In rabbits isolated CO2 and He-Ne laser irradiation promotes early granulation of wounds and accelerates epithelialization with more complete restitution of the regenerated skin organ specificity. The best effect was achieved when combined laser irradiation was applied. This was further corroborated by the immunohistochemical investigation.

[Somatic cell hybridization as 1 of the mechanisms explaining the inadequacy of immunologic surveillance]. / Somaticheskaia gibridizatsiia kletok pri rake kak odin iz mekhanizmov, ob"iasniaiushchikh nesostoiatel'nost' immunologicheskogo nadzora.

The literature analysis has shown that somatic cell hybridization is one of the mechanisms of tumour progression in vivo. This mechanism is suggested to underlie the establishment and development of human tumours, in particular of human breast cancer. Somatic hybridization of cells in human breast cancer is supposed to be one of the mechanisms responsible for the inadequacy of immunologic surveillance. The latter appears to occur in those cases when antigenic determinants of unchanged original cells predominate on the surface of hybrid formations.

[Role of modern methods of morphological research in the exact definition of the biological characteristics and morphogenesis of human breast cancer]. / Rol' sovremennykh metodov morfologicheskogo issledovaniia v utochnenii biologicheskikh osobennostei i morfogeneza raka molochnoi zhelezy cheloveka.

Combined use of modern methods of morphologic investigation will allow one in every diagnosed case of breast carcinoma to determine its histogenesis, make a differential diagnosis. Knowledge of biological features of malignant cells will allow one to apply an individual approach to treatment and prognosis. To clarify the morphogenesis of breast carcinoma, it is important to study the stromal component, as parenchymal-stromal relationship is a fundamental link in structural homeostasis.

[Ultrastructural characteristics of the parenchymatous and stromal components and their interrelationship in breast cancer]. / Ul'trastrukturnaia kharakteristika parenkhimatoznogo i stromal'nogo komponentov i ikh vzaimootnosheniia pri rake molochnoi zhelezy.

Ultrastructure of the epithelial components of mammary carcinoma is well studied; detection of the organ and tissue specific features enables the differential diagnostics with tumours of different histogenesis both in the metastatic nodes and in the mammary tumour tissue. Moreover, establishing a certain complex of the electron microscopic features for separate histological variants of mammary carcinoma favours the differential diagnostics between them. Including the ultracytochemical methods into the investigation complex will give an opportunity to clarify the role of some enzymes in he tumour growth. A detailed study of the mammary carcinoma stromal component will help in determining the function of tumour tissue.