[Serum lactate dehydrogenase isoenzyme spectrum in malignant neoplasm patients]. / Izofermentyi spektr laktatdegidrogenazy syvorotki krovi bol'nykh zlokachestvennymi opukholiami.

The isoenzymic spectrum of lactate dehydrogenase of blood sera was studied in 170 patients with malignant and benign tumors, chronic inflammatory lesions and in healthy persons. The characteristic changes in patients with malignant tumors were as follows: an increased activity of slow fractions and a decreased one in rapidly migrating fractions. The level of the 5th isoenzyme activity and the frequency of its increased activity in serum correlated well with the degree of cancer spread. The determination of a percentual content of the isoenzyme may be used as a supplementary test for diagnosing metastic involvement of the liver. The examination of the serum lactate dehydrogenase spectrum in patients with benign tumors and chronic inflammatory disease revealed no changes characteristic of malignant neoplasms.

[Effect of cobamide coenzyme on the growth of several transplantable tumors in rats and on prolonging the life of rats with grafted Zajdel ascitic tumor]. / Vliianie kobamidnogo kofermenta na rost nekotorykh privivaemykh opukholei u krys i na prodlenie zhizni krys s privitoi astsitnoi geptaomoi Zaidelia

The effect of the cobamide coenzyme (5,6-dimethylbenzimidazolyl-Co-5'-deoxyadenozylcobamide, DBC) on the growth of some forms of rat tumours and on the prolongation of survival of rats with implanted Zajdela ascites hepatoma was compared with that of cyanocobalamine (5,6-dimethylbenzimidazolyl-Co-cyanocobamide, CN-B12). The effect of DBC was shown to differ from that of CN-B12. DBC did not stimulate the growth of the investigated forms of tumours and prolonged survival of rats with implanted Zajdela ascites hepatoma. The rats displayed cancer resistance when DBC or CN-B12 were injected before implantation of tumours or Zajdela ascites hepatoma.