Subject(s)
Antibodies, Monoclonal , Psoriasis , Humans , Psoriasis/drug therapy , Italy , Treatment Outcome , Severity of Illness IndexSubject(s)
Antibodies, Monoclonal , Psoriasis , Humans , Psoriasis/drug therapy , Genitalia , Treatment Outcome , Severity of Illness IndexSubject(s)
Biological Products , Psoriasis , Humans , Aged , Psoriasis/drug therapy , Antibodies, Monoclonal, Humanized , Italy , Treatment Outcome , Severity of Illness IndexSubject(s)
COVID-19 , Exanthema , Psoriasis , Skin Diseases, Vesiculobullous , Antibodies, Monoclonal , BNT162 Vaccine , COVID-19 Vaccines , Humans , Psoriasis/drug therapy , RNA, MessengerSubject(s)
COVID-19 , Dermatology , Humans , Italy/epidemiology , Pandemics , SARS-CoV-2 , Time FactorsABSTRACT
INTRODUCTION: This is an Italian single-center retrospective study evaluating safety and efficacy of biologic agents in psoriatic patients with a previous diagnosis of malignant cancer. AIM: Management of moderate and severe psoriasis patients with a past medical history of malignancies could be difficult because biologic agents are historically associated with a presumptive increased risk of neoplastic reactivation or of a new incoming cancer. The aim of this study is to assess the safety of biologics in patients with a previous cancer diagnosis. MATERIAL AND METHODS: The study analyzed 16 moderate to severe psoriasis patients with a diagnosis of malignant cancer in the previous 10 years treated with biologic agents for up to at least 96 weeks. In five of these patients, cancer was diagnosed in the previous 5 years. RESULTS: We observed a rapid decrease in PASI (psoriasis area severity index) reaching a 90% improvement in 100% of patients. Oncologic follow up did not show any worsening or reactivation of cancer during the entire observation period. No new malignancies were observed in the analyzed sample. CONCLUSIONS: Biologic agents in our experience have demonstrated to be safe and effective in psoriatic patients with a past medical history of malignant cancer.
Subject(s)
Biological Therapy , Neoplasms , Psoriasis , Antibodies, Monoclonal/therapeutic use , Humans , Neoplasms/chemically induced , Neoplasms/complications , Psoriasis/pathology , Retrospective Studies , Severity of Illness Index , Treatment OutcomeABSTRACT
Gastrointestinal (GI) diseases, such as inflammatory bowel diseases (IBD), can manifest themselves with intestinal and extra-intestinal symptoms. Among the latter, cutaneous manifestations, such as pyoderma gangraenosum (PG) and metastatic Crohn's disease (MCD), represent a possible onset of IBD, with or without simultaneous bowel alterations. In such cases, intestinal and skin lesions are supported by the same immune-mediated mechanism. We hereby report two cases of patients with skin manifestations together with signs and symptoms suggestive of IBD. IBD and some skin lesions arise from the same immune-mediated mechanism. A multidisciplinary approach to these immune-mediated diseases is needed for an early and correct diagnosis, which in turn may lead to the use of the right drug avoiding useless treatment.
Subject(s)
Inflammatory Bowel Diseases/diagnosis , Skin Diseases/etiology , Adult , Crohn Disease/complications , Crohn Disease/diagnosis , Female , Humans , Inflammatory Bowel Diseases/complications , Middle Aged , Pyoderma Gangrenosum/etiologySubject(s)
Dermatitis/psychology , Self-Injurious Behavior/psychology , Self-Injurious Behavior/therapy , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/therapeutic use , Dermatitis/drug therapy , Dermatitis/etiology , Female , Histamine Antagonists/administration & dosage , Histamine Antagonists/therapeutic use , Humans , Male , Mental Disorders , Middle Aged , Naloxone/therapeutic use , Pruritus/psychologySubject(s)
Tinea Versicolor/diagnosis , Adolescent , Antifungal Agents/therapeutic use , Forearm/microbiology , Humans , Itraconazole/therapeutic use , Knee/microbiology , Malassezia/isolation & purification , Male , Tinea Versicolor/drug therapy , Tinea Versicolor/microbiology , Tinea Versicolor/pathologyABSTRACT
Systemic non-Hodgkin lymphomas are often accompanied by cutaneous manifestations, which are not always looked out for. Nevertheless, these alterations can be very important because their presence is lied to the clinical behaviour of the underlying malignancy, with an early recognition being fundamental. The aim of this study was to make order in this topic and propose a preliminary classification of the cutaneous manifestations associated with non-Hodgkin lymphomas. We performed a retrospective chart review of 62 haematological patients affected by non-Hodgkin systemic lymphomas with dermatological manifestations, who were evaluated from January 2007 to December 2011, and combined these results with a systematic review of Pub medical literature from 1937 to 2011 on this topic. A preliminary classification of these manifestations has been proposed, dividing them in specific and non-specific ones, along with a description of the clinical features and those cases observed in our department. A preliminary approach has been proposed for the study of these manifestations that could be helpful in understanding the biological behaviour and aid early recognition of a flare up in systemic non-Hodgkin lymphomas.
Subject(s)
Lymphoma, B-Cell/complications , Lymphoma, T-Cell/complications , Paraneoplastic Syndromes/classification , Skin Diseases/classification , Skin Diseases/etiology , Adult , Aged , Female , Humans , Lymphoma, B-Cell/pathology , Lymphoma, T-Cell/pathology , Male , Middle Aged , Paraneoplastic Syndromes/etiology , Retrospective Studies , Skin Diseases, Infectious/etiology , Skin Neoplasms/etiology , Young AdultABSTRACT
We report a case of Lichen Sclerosus in a 73-year-old man who had been treated for epilepsy with carbamazepine. Lichen sclerosus et atrophicus (LSA), also called lichen sclerosus (LS), is a chronic inflammatory cutaneous condition characterized by white plaques with epidermal atrophy and scarring. To date no cases of LSA has been linked to carbamazepine, although in a few cases lichenoid eruptions but without sclero-atrophy have been described after exposure to this drug. Therefore, to our knowledge, this is the first report of a Lichen sclerosus et atrophicus induced by carbamazepine.
Subject(s)
Anticonvulsants/adverse effects , Carbamazepine/adverse effects , Drug Eruptions/etiology , Epilepsy, Tonic-Clonic/drug therapy , Lichen Sclerosus et Atrophicus/chemically induced , Administration, Topical , Aged , Carbamazepine/analogs & derivatives , Carbamazepine/therapeutic use , Drug Eruptions/diagnosis , Drug Eruptions/drug therapy , Drug Substitution , Humans , Lichen Sclerosus et Atrophicus/diagnosis , Lichen Sclerosus et Atrophicus/drug therapy , Male , Steroids/administration & dosage , Treatment OutcomeABSTRACT
Magnesium stearate is a substance often used as a diluent in the manufacture of medical tablets, capsules and powders. Moreover it is usually found as a food additive or pharmaceutical excipient. We report the first case of a 28 years old woman affected by an allergic reaction from this substance with an urticarial manifestation.
Subject(s)
Allergens/immunology , Stearic Acids/immunology , Urticaria/etiology , Adult , Female , HumansABSTRACT
Dopamine is a neurotransmitter which plays an important role in many human organs including the skin. In this study we will examine the presence and the distribution of D1 and D2 dopamine receptors in a particular zone of the human skin. Samples of the human plantar skin were harvested during autopsies after the consent of relatives of the dead donors. In this study the following experimental procedures were performed: 1) drawing of the human plantar skin; 2) cutting of tissues; 3) staining of tissues; 4) staining of the nerve fibres; 5) radio-binding methods for labelling D1 and D2 dopamine receptors; 6) light microscope autoradiography; 7) quantitative analysis of images and 8) statistical analysis of data. The dopamine receptors D1 are distributed particularly in the dermis layer of the human plantar skin. They are numerous in lower epidermal layers (with exclusion of the corneal layer) and few in subcutaneous tissue. On the contrary D2 dopamine receptors are prominent in the subcutaneous tissue near the vessels. Quantitative analysis of images and statistical analysis of the data confirm all our results. The specific distribution of D1 and D2 dopamine receptors in the human plantar skin is in close relation with the functions of a particular zone of the human skin that supports the weight of all the body. Moreover the character of dopamine receptors distribution is very important for further understanding the role of these receptors in the human skin.
Subject(s)
Receptors, Dopamine D1/analysis , Receptors, Dopamine D2/analysis , Skin/chemistry , Autoradiography , Benzazepines/metabolism , Humans , Nerve Fibers/chemistry , Spiperone/metabolismABSTRACT
Airborne contact dermatitis is a dermatological disease manifesting predominantly on the face, neck and arms, which is caused by volatile substances which settle on exposed skin. Although the diagnosis is not difficult, the finding of causative allergens and the exclusion of differential diagnoses are still lacking by the treating dermatologists.