1.
Pediatr Infect Dis J
; 34(11): 1214-7, 2015 Nov.
Article
in English
| MEDLINE
| ID: mdl-26226442
ABSTRACT
In 188 HIV-infected children receiving efavirenz, a lower mid-dose (C12) was associated with a higher risk of HIV-1 viral load >400 copies/mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C12 below target threshold (<1.0 mg/L) with a 23% risk of viral replication.
Subject(s)
Benzoxazines/blood , HIV Infections/drug therapy , HIV Infections/virology , Reverse Transcriptase Inhibitors/blood , Viral Load/drug effects , Alkynes , Benzoxazines/pharmacokinetics , Benzoxazines/pharmacology , Benzoxazines/therapeutic use , Child , Cohort Studies , Cyclopropanes , Female , HIV-1/drug effects , Humans , Male , Reverse Transcriptase Inhibitors/pharmacokinetics , Reverse Transcriptase Inhibitors/pharmacology , Reverse Transcriptase Inhibitors/therapeutic use
2.
J Acquir Immune Defic Syndr
; 62(1): e27-9, 2013 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-23262981
