ABSTRACT
This retrospective review of hospital records analysed pregnancy outcome with 2 different treatments for women with recurrent miscarriage diagnosed with antiphospholipid syndrome in the index pregnancy. Of 64 women, 29 had received aspirin and 35 aspirin plus heparin. Pregnancy-induced hypertension, prematurity, intrauterine growth restriction and neonatal death were considered as maternal and fetal complications. There were no significant differences in antenatal and maternal complications between the groups. HOwever, there were significant differences in mean anticardiolipin IgG antibody levels. Aspirin alone or in combination with parin was equally efficacious in women with antiphospholipid syndrome and recurrent miscarriage.
Subject(s)
Antiphospholipid Syndrome/drug therapy , Aspirin/therapeutic use , Fibrinolytic Agents/therapeutic use , Heparin/therapeutic use , Pregnancy Complications/drug therapy , Pregnancy Outcome/epidemiology , Adult , Antibodies, Anticardiolipin/blood , Antibodies, Anticardiolipin/drug effects , Antiphospholipid Syndrome/blood , Antiphospholipid Syndrome/complications , Antiphospholipid Syndrome/immunology , Aspirin/pharmacology , Chi-Square Distribution , Drug Therapy, Combination , Female , Fibrinolytic Agents/pharmacology , Heparin/pharmacology , Humans , Immunoglobulin G/blood , Immunoglobulin G/drug effects , Immunoglobulin M/blood , Immunoglobulin M/drug effects , Pakistan/epidemiology , Pregnancy , Pregnancy Complications/blood , Pregnancy Complications/immunology , Retrospective Studies , Treatment OutcomeABSTRACT
This retrospective review of hospital records analysed pregnancy outcome with 2 different treatments for women with recurrent miscarriage diagnosed with antiphospholipid syndrome in the index pregnancy. Of 64 women, 29 had received aspirin and 35 aspirin plus heparin. Pregnancy-induced hypertension, prematurity, intrauterine growth restriction and neonatal death were considered as maternal and fetal complications. There were no significant differences in antenatal and maternal complications between the groups. However, there were significant differences in mean anticardiolipin IgG antibody levels. Aspirin alone or in combination with heparin was equally efficacious in women with antiphospholipid syndrome and recurrent miscarriage
Subject(s)
Pregnancy Outcome , Retrospective Studies , Antibodies, Anticardiolipin , Antiphospholipid Syndrome , Abortion, Spontaneous , Heparin , Aspirin , Treatment OutcomeSubject(s)
Ascites/complications , Endometriosis/complications , Escherichia coli Infections/complications , Ovarian Cysts/complications , Pleural Effusion/complications , Adult , Ascites/pathology , Ascites/surgery , Endometriosis/pathology , Endometriosis/surgery , Escherichia coli Infections/pathology , Escherichia coli Infections/surgery , Female , Humans , Ovarian Cysts/pathology , Ovarian Cysts/surgery , Pleural Effusion/pathology , Pleural Effusion/surgeryABSTRACT
Intracellular free calcium is regulated by Ca(++)-ATPase, one form present on the plasma membrane (PM Ca(++)-ATPase) and the other on sarcoplasmic (endoplasmic) reticulum (SR/ER Ca(++)-ATPase). An endogenous inhibitor of SR Ca(++)-ATPase from human placenta was shown to be present in normal placenta and the activity was not detectable in placenta from preeclamptic patients. The inhibitor was distributed in cytosol and microsomes. The inhibition of Ca(++)-ATPase by this inhibitor was concentration- and time-dependent. The inhibitor neither bound to DEAE- nor CM-sepharose resins at pH 7.5 and 8.5. Furthermore, it was heat stable for 15 min up to 55 degrees C and completely destroyed at 80 degrees C in a few minutes. It was also observed to be stable at room temperature for at least 3 months. The purification and characterization of this inhibitor would be valuable in achieving an understanding of the normal regulation of Ca(++)-ATPase in the placenta during pregnancy.
Subject(s)
Calcium-Transporting ATPases/antagonists & inhibitors , Enzyme Inhibitors/metabolism , Placenta/metabolism , Animals , Cytosol/metabolism , Female , Humans , Microsomes/metabolism , Pregnancy , Rabbits , TemperatureABSTRACT
This is a retrospective case control study. Out of a total of 1238 births occurring over a period of 8 months at the Aga Khan University Medical Centre, Karachi, 9.4% were preterm. Factors found to be associated with preterm labour were age > 35, height < 156 cm, anaemia or urinary tract infection in pregnancy, abruptio placentae, polyhydramnios, preterm rupture of membranes, intrauterine growth retardation, fetal distress and intrauterine death. Previous bad obstetric history was also relevant. A preterm baby was found to be at higher risk of postnatal complications resulting in neonatal death or admission to the Neonatal Intensive Care Unit (NICU) than a full term baby.
