ABSTRACT
BACKGROUND: Whole-body cryotherapy (WBC) is used as a conditioning method for athletes. However, the scientific evidence for its effects is still insufficient. OBJECTIVE: To elucidate the effects of transient WBC on the expression of heat shock protein (HSP) 70 and the secretion of related hormones in humans. MATERIALS AND METHODS: The participants in this study were six healthy adult men. WBC was performed for 3 min in a booth at a temperature in the range of -150 to -120 degree C, and measurements were taken immediately before (Pre), immediately after (Post), and 60 min after WBC (Post60). For measurement of core body temperature (gastrointestinal temperature), participants ingested a capsule-type wireless temperature sensor. The body surface temperature was measured using a noncontact thermometer, and measurements were taken at four sites on the body surface (chest, abdomen, front of the thigh, and front of the lower thigh). Leukocyte count, lactate dehydrogenase, creatine kinase, hemoglobin, hematocrit, adrenaline, noradrenaline, cortisol, adrenocorticotropic hormone (ACTH), erythropoietin, and HSP70 in the collected blood were measured. RESULTS: The results showed a decrease in body surface temperature and an increase in noradrenaline and ACTH immediately after WBC. In addition, the core body temperature decreased 60 min after WBC, accompanied by an increase in HSP70 expression. CONCLUSION: WBC may increase HSP70 expression via noradrenaline and ACTH. The results of this study suggest the usefulness of WBC in triggering protein synthesis and the maintenance of immune function after training. doi.org/10.54680/fr22210110512.
Subject(s)
Cryopreservation , Cryotherapy , Male , Adult , Humans , Cryotherapy/methods , Adrenocorticotropic Hormone , NorepinephrineABSTRACT
The effectiveness and the safety of panipenem/betamipron, new antibiotics of the carbapenems for burn infections, were studied and the following results were obtained: 1. The preparation, 0.5 g/0.5 g, was administered by intravenous drip infusion twice a day to 11 cases of patients with burn infections. In 10 cases for which clinical effects were evaluable, results were rated as "excellent" in 2 cases, "good" in 2 cases and "fair" in 6 cases, with an efficacy rate of 40%. 2. Penetration to the affected tissue was studied in 2 cases. The tissue level of panipenem was 0.20 micrograms/g immediately after the end of drip infusion and 6.86 micrograms/g 60 minutes thereafter. 3. As for the safety, a slight increase in GOT, GPT and Al-P was noted in 1 case; a slight increase in GPT, NAG and beta 2MG was found in 1 case; and a slight increase in GOT, GPT, Al-P and LAP was noted in 1 case, as abnormal variations in laboratory test results.
Subject(s)
Burns/complications , Skin Diseases, Infectious/drug therapy , Surgery, Plastic , Thienamycins/therapeutic use , Wound Infection/drug therapy , beta-Alanine/analogs & derivatives , Adolescent , Aged , Aged, 80 and over , Burns/metabolism , Burns/surgery , Child , Drug Evaluation , Drug Therapy, Combination/pharmacokinetics , Drug Therapy, Combination/therapeutic use , Female , Humans , Male , Middle Aged , Skin Diseases, Infectious/etiology , Skin Diseases, Infectious/metabolism , Thienamycins/pharmacokinetics , Tissue Distribution , Wound Infection/etiology , Wound Infection/metabolism , beta-Alanine/pharmacokinetics , beta-Alanine/therapeutic useABSTRACT
We studied the three-dimensional (3D) deformities in patients with congenital facial anomalies, such as cleft lip and palate or hemifacial microsomia using three-dimensional CT (3DCT) images. At the same time, the data from the 3DCT was processed and analyzed using a 3DCT measurement system which we have recently developed. The coordinates of the 67 test points on the craniofacial bones were determined on a 3D image prepared by the 3DCT measurement system. Using this system, we prepared the 'skeletograms', which present deformities of craniofacial bones in detail as a 3D wire frame model, for detailed analysis of the craniofacial bones' deformities.
