ABSTRACT
The paper presents the changes found in the lipid spectrum in 48, platelet aggregation in 23 and microcirculation in 35 patients with coronary heart disease after plasmapheresis. In patients with Functional Classes III and IV angina, repeated procedures of plasmapheresis were found to result in a clinical improvement of its course in 92% of the patients and in conversion to a lower functional class of angina in 71%. Massive plasmapheresis performed by the developed methods caused a significant improvement in the lipid spectrum, blood rheology, and microcirculation, which persisted for 1 to 6 months after plasmapheresis in relation to the type of hyperlipoproteinemia.
Subject(s)
Angina Pectoris/therapy , Lipid Metabolism , Microcirculation , Plasmapheresis , Platelet Aggregation , Adult , Aged , Angina Pectoris/blood , Angina Pectoris/metabolism , Angina, Unstable/blood , Angina, Unstable/metabolism , Angina, Unstable/therapy , Cholesterol/blood , Humans , Lipids/blood , Middle Aged , Triglycerides/bloodSubject(s)
Anti-Arrhythmia Agents/therapeutic use , Coronary Disease/drug therapy , Dibenzazepines/therapeutic use , Adult , Aged , Anti-Arrhythmia Agents/administration & dosage , Anti-Arrhythmia Agents/pharmacology , Arrhythmias, Cardiac/drug therapy , Coronary Disease/physiopathology , Dibenzazepines/administration & dosage , Dibenzazepines/pharmacology , Drug Evaluation , Electrocardiography , Female , Heart/drug effects , Heart/physiopathology , Heart Conduction System/drug effects , Humans , Injections, Intravenous , Male , Middle AgedSubject(s)
Angina Pectoris/therapy , Plasmapheresis , Work Capacity Evaluation , Adult , Aged , Angina Pectoris/rehabilitation , Exercise Test , Female , Humans , Male , Middle AgedABSTRACT
Investigation of the hypotensive action of minipress, a drug belonging to the group of selective blockers of alpha 1-adrenoreceptors, shows its efficacy in 56.3 percent of patients with stage II essential hypertension. The side-effects were recorded in 16.6 percent of the patients. It is noted that application of minipress at a mean daily dose of 3.4 ml for a long time reduces the total peripheral vascular resistance without inducing any substantial changes in the stroke volume of the heart or in the pulse rate. At the same time minipress produces a beneficial effect on the microcirculatory blood flow.
Subject(s)
Hypertension/drug therapy , Prazosin/therapeutic use , Adult , Aged , Erythrocyte Aggregation/drug effects , Female , Hemodynamics/drug effects , Humans , Hypertension/physiopathology , Male , Middle Aged , Prazosin/adverse effects , Pulse/drug effects , Stroke Volume/drug effectsSubject(s)
Arrhythmias, Cardiac/drug therapy , Conjunctiva/blood supply , Lidocaine/therapeutic use , Platelet Aggregation/drug effects , Pyrrolidines/therapeutic use , Adult , Aged , Arrhythmias, Cardiac/physiopathology , Clinical Trials as Topic , Female , Humans , Male , Microcirculation/drug effects , Middle AgedABSTRACT
Platelet aggregation, prostacyclin and thromboxane were studied in 35 individuals: 20 coronary patients with angina of effort and 15 high-risk patients before and after treatment with lidocaine and pyromecaine. Oral administration of lidocaine and pyromecaine pills considerably depresses platelet aggregation and even causes platelet disaggregation. However, lidocaine disaggregating effect is greater than that of pyromecaine. Both agents affect vascular hemostasis by reducing thrombaxane and raising prostacyclin levels. Hence, the anti-aggregant effect of anti-arrhythmic proocaines may be attributed to changes in vascular hemostasis. The results obtained are expanding the range of indications for the use of these drugs.
