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1.
J Endocrinol Invest ; 47(7): 1691-1700, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38526837

ABSTRACT

PURPOSE: Patients with beta-thalassemia major (BTM) often develop several endocrine disorders due to chronic iron overload. They are also prone to osteoporosis and vertebral fractures. Plasmatic insulin-like growth factor-1 (IGF-1) levels are often low in subjects with BTM, which origin is multifactorial. The aim of this study was to evaluate a possible relationship between serum IGF-1 levels and the presence of osteoporosis and/or vertebral fractures. METHODS: We retrospectively evaluated the occurrence of vertebral fractures in 30 adult male patients affected by BTM (mean age 43.3 ± 7.9 years) with low serum IGF-1 (median value 52.4 ng/ml, 38.5-83.4). Only 6 of them (20.0%) were diagnosed with GH deficiency (GHD) after GHRH/arginine stimulation test, while 23 (76.7%) had osteoporosis and 12 (40.0%) had known vertebral fractures. All patients except one also showed at least one endocrine disorder. RESULTS: Serum IGF-1 was significantly lower in BTM patients with vertebral fractures compared to patients without vertebral fractures (U = 41.0, p = 0.005) while it was not significantly different between patients with low bone mass compared to patients without low bone mass. The diagnosis of GHD was significantly associated with lower serum IGF-1 (p = 0.001) and vertebral fractures (p = 0.002) but not with low bone mass. After ROC analysis, we found that very low IGF-1 (≤ 50.0 ng/dl) was associated with vertebral fractures (sensitivity 83.3%, specificity 75.0%) and was also predictive of GHD (sensitivity 75.0%, specificity 100.0%). CONCLUSION: Our study shows that, in male patients with BTM, serum IGF-1 ≤ 50.0 ng/dl is a marker of vertebral fractures and it is predictive of a diagnosis of GHD.


Subject(s)
Biomarkers , Insulin-Like Growth Factor I , Spinal Fractures , beta-Thalassemia , Humans , Male , Insulin-Like Growth Factor I/analysis , Insulin-Like Growth Factor I/metabolism , Adult , Spinal Fractures/blood , Spinal Fractures/epidemiology , Spinal Fractures/etiology , Spinal Fractures/diagnosis , Retrospective Studies , beta-Thalassemia/blood , beta-Thalassemia/complications , beta-Thalassemia/diagnosis , Biomarkers/blood , Osteoporosis/blood , Osteoporosis/etiology , Osteoporosis/diagnosis , Middle Aged , Prognosis
2.
J Endocrinol Invest ; 2024 Mar 15.
Article in English | MEDLINE | ID: mdl-38488977

ABSTRACT

PURPOSE: Graves' ophthalmopathy (GO) is an autoimmune disease that affects orbital soft tissues and represents the most common extrathyroidal manifestation of Graves' disease (GD). The European Group of Graves' Ophthalmopathy (EUGOGO) has attempted to shed light on the European epidemiological picture of GO, suggesting that GO in newly diagnosed patients in recent years has a trend towards a less severe clinical presentation. There are no studies that focus this issue on the population of our area; we aimed to evaluate the trend of GO clinical presentation in our outpatient clinic through an observation period of 10 years. METHODS: We compared 55 consecutive patients, 11 males (F) and 44 females (M), who came to our observation from January 2005 to December 2006 [Group 1 (G1)], with 56 patients, 15 males, and 41 females, who were referred to us from 2015 to 2016 [Group 2 (G2)]. We studied the following putative predictors of GO presentation and severity: thyroid function, smoking, diabetes, hypercholesterolemia, time from GO diagnosis to referral to our thyroid centre (TGOD), sex and age. RESULTS: GO severity was significantly reduced in G2 vs. G1 (p = 0.04). TGOD ≥ 3 months was related to clinical characteristics of GO (severity and Clinical Activity Score ≥ 4) and was an independent predictor of GO severity (p = 0.01). The other variables evaluated had no independent effects. CONCLUSIONS: We found that GO severity at presentation was significantly reduced over a ten-year observation period (2005-2006 vs. 2015-2016) in GO patients referred to our tertiary thyroid centre. TGOD ≥ 3 months was an independent predictor of GO severity.

4.
Ann Rheum Dis ; 74(11): 2043-9, 2015 Nov.
Article in English | MEDLINE | ID: mdl-25038238

ABSTRACT

OBJECTIVE: To evaluate genetic, demographic and clinical features in patients with cryopyrin-associated periodic syndrome (CAPS) from the Eurofever Registry, with a focus on genotype-phenotype correlations and predictive disease severity markers. METHODS: A web-based registry retrospectively collected data on patients with CAPS. Experts in the disease independently validated all cases. Patients carrying NLRP3 variants and germline-mutation-negative patients were included. RESULTS: 136 patients were analysed. The median age at disease onset was 9 months, and the median duration of follow-up was 15 years. Skin rash, musculoskeletal involvement and fever were the most prevalent features. Neurological involvement (including severe complications) was noted in 40% and 12% of the patients, respectively, with ophthalmological involvement in 71%, and neurosensory hearing loss in 42%. 133 patients carried a heterozygous, germline mutation, and 3 patients were mutation-negative (despite complete NLRP3 gene screening). Thirty-one different NLRP3 mutations were recorded; 7 accounted for 78% of the patients, whereas 24 rare variants were found in 27 cases. The latter were significantly associated with early disease onset, neurological complications (including severe complications) and severe musculoskeletal involvement. The T348M variant was associated with early disease onset, chronic course and hearing loss. Neurological involvement was less strongly associated with V198M, E311 K and A439 V alleles. Early onset was predictive of severe neurological complications and hearing loss. CONCLUSIONS: Patients carrying rare NLRP3 variants are at risk of severe CAPS; onset before the age of 6 months is associated with more severe neurological involvement and hearing loss. These findings may have an impact on treatment decisions.


Subject(s)
Carrier Proteins/genetics , Cryopyrin-Associated Periodic Syndromes/genetics , Registries , Adolescent , Adult , Alleles , Arthralgia/etiology , Arthralgia/genetics , Arthritis/etiology , Arthritis/genetics , Child , Child, Preschool , Cohort Studies , Conjunctivitis/etiology , Conjunctivitis/genetics , Cryopyrin-Associated Periodic Syndromes/complications , Cryopyrin-Associated Periodic Syndromes/physiopathology , Europe , Exanthema/etiology , Exanthema/genetics , Female , Genotype , Germ-Line Mutation , Headache/etiology , Headache/genetics , Hearing Loss, Sensorineural/etiology , Hearing Loss, Sensorineural/genetics , Heterozygote , Humans , Infant , Male , Meningitis/etiology , Meningitis/genetics , Mutation , Myalgia/etiology , Myalgia/genetics , NLR Family, Pyrin Domain-Containing 3 Protein , Papilledema/etiology , Papilledema/genetics , Phenotype , Retrospective Studies , Severity of Illness Index , Uveitis/etiology , Uveitis/genetics , Young Adult
6.
Childs Nerv Syst ; 23(2): 219-23, 2007 Feb.
Article in English | MEDLINE | ID: mdl-17058088

ABSTRACT

OBJECTS: Genetic syndromes associated with ependymoma are uncommon, with the exception of NF2. We describe two cases of ependymoma presenting with Klinefelter's Syndrome (KS) as co-morbid condition. MATERIALS AND METHODS: The first patient was diagnosed for KS during pregnancy; he also presented a thyroid agenesis and a deficit of methyltetrahydrofolate reductase (MTHFR); at 30 months of age he was operated on for a grade II ependymoma of IV ventricle; after a multiple-stage surgery, he underwent oral chemotherapy and stereotactic radiotherapy, but after 15 months he presented a local recurrence and died. The second patient was diagnosed for KS at the age of 16 months; at 10 years of age, due to back pain, he underwent an MRI, which showed a cauda equine tumor. He underwent surgery and radiotherapy. Histology was of mixopapillary ependymoma. CONCLUSION: In a review of literature, various neoplasms have been described in association with KS. To our knowledge, these are the first two cases reported of ependymoma associated to KS. A retrospective study of 44 monoinstitutional ependymoma cases demonstrated association with genetic syndromes in 22%.


Subject(s)
Central Nervous System Neoplasms/genetics , Ependymoma/genetics , Klinefelter Syndrome/genetics , Methylenetetrahydrofolate Reductase (NADPH2)/deficiency , Central Nervous System Neoplasms/complications , Child , Child, Preschool , Ependymoma/complications , Glial Fibrillary Acidic Protein/metabolism , Humans , Klinefelter Syndrome/complications , Male
7.
Horm Res ; 51(4): 168-72, 1999.
Article in English | MEDLINE | ID: mdl-10474017

ABSTRACT

Recently, 1997, Tanner and co-workers provided a new scale converting TW-RUS standard maturity scores to skeletal age for European North American youths (US90). The aim of the present study was to test if the accuracy of TW-RUS bone age assessments in the Italian population could be improved by evaluating the estimates obtained with this new scale in comparison with other standards (UK60: original British series, B70: Belgian series and S80: Spanish series). 1,831 hand-wrist radiographs (Italian healthy subjects aged from 8 to 16.8 years) were evaluated. The US90 reference values are resulted the most suitable TW-RUS standards. Therefore, it seems useful to update the reference values of TW-RUS SMS in Italian youths, using this new scale.


Subject(s)
Age Determination by Skeleton/methods , Aging/physiology , Bone Development , Adolescent , Child , Female , Humans , Italy , Male , Reference Standards
8.
J Pediatr Gastroenterol Nutr ; 29(3): 339-42, 1999 Sep.
Article in English | MEDLINE | ID: mdl-10468002

ABSTRACT

BACKGROUND: The aim of this study was to report on the long-term growth and development in a group of treated patients with celiac disease. METHODS: The study includes 26 patients (11 boys and 15 girls) with typical celiac disease who were younger than 2.5 at diagnosis and were followed by means of a growth longitudinal monitoring from the introduction of a gluten-free diet (mean age, 1.7 +/- 0.5 years) until adulthood, over a median period of 15.3 years. Growth indicators used were: height, skeletal age, weight and BMI. RESULTS: At the time of admission, the patients had a general tendency to short stature, underweight and retarded skeletal maturation. They did not catch up completely in height and skeletal age after a dietary treatment period of 3 years. Most of them were seen to be slightly below average height for age during childhood and adolescence with skeletal maturity retardation, even if a fairly large interindividual variation of height profiles was evident. CONCLUSIONS: Notwithstanding the early treatment, the careful follow-up, and the good adhesion to the dietary rules of the patients under study, slight negative effects of the disease on growth were not avoided.


Subject(s)
Bone Development , Celiac Disease/diet therapy , Celiac Disease/physiopathology , Growth , Body Height , Body Mass Index , Child, Preschool , Female , Glutens/administration & dosage , Humans , Infant , Longitudinal Studies , Male
9.
Pediatr Radiol ; 28(11): 851-5, 1998 Nov.
Article in English | MEDLINE | ID: mdl-9799317

ABSTRACT

A pair of monozygotic twin girls with trichorhinophalangeal syndrome type I (TRPS I), followed from 8.3 to 16.1 years of age, is described. Both showed typical dysmorphic features and severe short stature, but only one had Perthes-like changes in the right capital femoral epiphysis. The radiographic findings and evolutionary changes of phalangeal cone-shaped epiphyses (PCSE) of the hands are illustrated in this report. The unusual bone maturation and growth of the twins are also described. Both presented poor growth and delayed bone age until about 13 years, followed by marked acceleration of bone age and stunted pubertal height spurt.


Subject(s)
Diseases in Twins/diagnosis , Femur/diagnostic imaging , Growth , Legg-Calve-Perthes Disease/diagnostic imaging , Osteochondrodysplasias/diagnostic imaging , Twins, Monozygotic , Adolescent , Epiphyses/diagnostic imaging , Epiphyses/pathology , Female , Femur/pathology , Hand/diagnostic imaging , Humans , Legg-Calve-Perthes Disease/pathology , Osteochondrodysplasias/pathology , Pelvic Bones/diagnostic imaging , Phenotype , Radiography
10.
Clin Genet ; 53(5): 391-5, 1998 May.
Article in English | MEDLINE | ID: mdl-9660059

ABSTRACT

Severe hypercholesterolemia was found in an 11-year-old boy with no family history of familial hypercholesterolemia. The reduced LDL-receptor activity in cultured skin fibroblasts (40% 125I-LDL degradation as compared with a control cell line) indicated the presence of an LDL-receptor defect. The analysis of the promoter region and the exons of LDL-receptor gene by single strand conformation polymorphism revealed an abnormal migration pattern in exon 1, which was due to a T --> A transversion at nucleotide 28 of the cDNA. This novel mutation causes an arginine for tryptophane substitution at position - 12 of the signal peptide (W-12R) and introduces an AviII restriction site in exon 1. Screening of the mutation by polymerase chain reaction (PCR) amplification of exon 1 and AviII digestion revealed that none of the proband's family members carried the mutation. Non-paternity was excluded after the analysis of a battery of 14 short tandem repeats located in 13 different chromosomes. These results are consistent with the hypothesis that the proband is heterozygous for a 'de novo' mutation of the LDL-receptor gene producing a non-conservative amino acid substitution. We suggest that the change in the net charge of the signal peptide, caused by the addition of a positively charged amino acid, impairs the co-translational translocation of the nascent receptor protein across the endoplasmic reticulum membrane.


Subject(s)
Genes/genetics , Hypercholesterolemia/genetics , Receptors, LDL/genetics , Adolescent , Adult , Amino Acid Substitution , Cholesterol/blood , Exons/genetics , Family Health , Fathers , Humans , Hypercholesterolemia/blood , Hypercholesterolemia/epidemiology , Italy/epidemiology , Male , Middle Aged , Mothers , Nuclear Family , Point Mutation/genetics
11.
J Pediatr Endocrinol Metab ; 11 Suppl 3: 817-25, 1998.
Article in English | MEDLINE | ID: mdl-10091152

ABSTRACT

We report skeletal changes due to deferoxamine (DF) in 15/29 patients with transfusion-dependent thalassaemia major (TM), followed longitudinally for growth assessment. Clinically the earliest signs were decline in height and/or sitting height growth rate, leg and back pain with restricted movement and limb deformity. Radiologically metaphyseal and spinal changes were seen in 5 subjects and vertebral lesions alone in 10. The metaphyseal changes were mild, moderate or severe and affected all long bones, but were most pronounced at wrists and knees. They progressed from widening of the growth plate and defects of metaphyseal margins to appearance of radiolucent pseudocystic areas and, in severe cases, of cupped, rickets-like metaphyses. The spinal changes proceeded from osseous defects of ventral upper and lower edges of vertebrae and biconvex contours of end-plates to platyspondyly with decreased vertebral body height. After DF dose reduction, metaphyseal changes regressed in 2 patients, while they progressed in 3, requiring corrective surgery for severe valgus knee. Spinal abnormalities either remained unchanged or progressed. Final height was very short in patients with spondylometaphyseal lesions, short and disproportionate in patients with only spinal involvement.


Subject(s)
Bone Diseases, Developmental/chemically induced , Deferoxamine/adverse effects , Iron Chelating Agents/adverse effects , beta-Thalassemia/therapy , Adolescent , Adult , Blood Transfusion , Body Height , Bone Diseases, Developmental/diagnostic imaging , Female , Follow-Up Studies , Growth Disorders/chemically induced , Growth Plate/diagnostic imaging , Human Growth Hormone/therapeutic use , Humans , Knee , Male , Radiography , Spinal Diseases/chemically induced , Spinal Diseases/diagnostic imaging , Wrist , beta-Thalassemia/physiopathology
12.
Clin Exp Allergy ; 27(8): 949-56, 1997 Aug.
Article in English | MEDLINE | ID: mdl-9291294

ABSTRACT

BACKGROUND: Hydrolysed casein and whey protein formulas have been developed with the aim of preventing sensitization in infants at high risk of cow milk allergy. Subsequently these products have also been used for treatment of children with cow milk allergy. However, severe reactions have occurred in some allergic infants fed with these formulas raising doubts about their absolute safety and suggest the need for developing in vitro techniques for detection of eventual residual allergenic activity in such preparations. OBJECTIVES: Our purpose was to evaluate the usefulness of monoclonal and polyclonal antibodies against casein components (alpha, beta and kappa casein) as reagents for the detection of the residual antigenic activity of casein components in several hydrolysed formulas. METHODS: The monoclonal and polyclonal antibodies were produced according to standard procedures by immunizing female Balb/c mice with casein fraction (a mixture of alpha, beta and kappa casein). ELISA assays were developed to test the specificity of the antibodies and to detect and evaluate the amount of residual antigenic activity of the casein components in hydrolysed formulas. RESULTS: Use of polyclonal antiserum specific for casein allowed detection of residual antigenic activity of casein components in all partial hydrolysates and in the two extensive whey protein hydrolysates in the amounts ranging from 0.05 to 0.67% of total protein. No such activity was detectable in either the two extensive casein hydrolysates tested or the aminoacid based formula. The polyclonal antiserum proved to be more suitable than monoclonals for detecting residual antigenic activity in the hydrolysates. The monoclonal antibodies were directed against epitopes expressed on different casein components. CONCLUSIONS: In this study the ELISA inhibition assay with polyclonal antibodies specific for casein components of cow milk proved to be a sensitive method for estimating residual antigenicity in the hydrolysed formulas commercially available for infants with cow milk allergy suggesting their potential application for the quality control of hypoallergenic infant formulas.


Subject(s)
Antibodies, Monoclonal/immunology , Antibodies/immunology , Antigens/analysis , Antigens/immunology , Caseins/immunology , Food Hypersensitivity/prevention & control , Infant Food/analysis , Milk/immunology , Animals , Antibody Specificity , Antigen-Antibody Reactions/immunology , Caseins/analysis , Enzyme-Linked Immunosorbent Assay , Female , Humans , Hydrolysis , Immune Sera/immunology , Infant , Infant, Newborn , Mice , Mice, Inbred BALB C , Milk Hypersensitivity/immunology , Milk Proteins/analysis , Milk Proteins/immunology , Protein Hydrolysates/analysis , Protein Hydrolysates/immunology
13.
Am J Med Genet ; 73(3): 263-6, 1997 Dec 19.
Article in English | MEDLINE | ID: mdl-9415681

ABSTRACT

We describe a girl with Niikawa-Kuroki (Kabuki) syndrome (NKS) with conical incisors, hypodontia, hypoplastic nails, and brittle hair. Abnormal teeth are common in NKS and support a hypothesis of autosomal dominant inheritance of the syndrome [Halal et al., 1989; Silengo et al., 1996]. Hair abnormalities have never been investigated in NKS. The ectodermal involvement in NKS could represent an important clue for the understanding of the pathogenesis of this syndrome.


Subject(s)
Abnormalities, Multiple/pathology , Anodontia/pathology , Bone and Bones/abnormalities , Child , Face/abnormalities , Female , Hair/abnormalities , Hearing Loss, Sensorineural/genetics , Humans , Incisor/abnormalities , Intellectual Disability/genetics , Nails, Malformed , Syndrome
15.
Clin Genet ; 49(1): 37-41, 1996 Jan.
Article in English | MEDLINE | ID: mdl-8721570

ABSTRACT

In this report, we describe a male infant with a 45,X karyotype; the entire short arm and the centromere of the Y chromosome were translocated onto the short arm of chromosome 18, resulting in an unbalanced dicentric chromosome. Breakpoints were identified by in situ fluorescence hybridization (FISH) on the proximal Yq11 and 18p11.2. Both Y and 18 centromeric alphoid sequences were identified on the derived 18 chromosome. Clinical features were compatible with 18p- syndrome and no Turner stigmata were present in our propositus. Short stature was likely to be related to the deletion of 18p and/or Yq, where a gene involved in stature determination has been located proximal to a gene involved in spermatogenesis (AZF).


Subject(s)
Abnormalities, Multiple/genetics , Chromosomes, Human, Pair 18 , Translocation, Genetic , X Chromosome , Y Chromosome , Abnormalities, Multiple/physiopathology , Child, Preschool , Dwarfism/genetics , Dwarfism/physiopathology , Face/abnormalities , Humans , In Situ Hybridization, Fluorescence , Karyotyping , Male , Phenotype
16.
J Lipid Res ; 36(6): 1315-24, 1995 Jun.
Article in English | MEDLINE | ID: mdl-7545204

ABSTRACT

A novel point mutation of the LDL-receptor gene was found in an Italian patient with homozygous familial hypercholesterolemia. The SSCP analysis of the promoter and of 16 out of the 18 exons of the LDL-receptor gene was negative, suggesting that the mutation might be located in the region of the gene encompassing exons 14 and 15, a region that had not been amenable to polymerase chain reaction (PCR) amplification from genomic DNA. This region was amplified from cDNA by reverse transcription PCR (RT-PCR). RT-PCR of proband cDNA generated three fragments of 800, 600, and 550 bp, respectively, as opposed to a single 720 bp fragment obtained from control cDNA. The sequence of these fragments showed that: i) in the 800-bp fragment exon 14 continued with the 5' end of intron 15 (90 nucleotides), which in turn was followed by exon 16; ii) in the 600-bp fragment exon 14 was followed by the 5' end of exon 15 (50 nucleotides), which continued with exon 16; iii) in the 550-bp fragment exon 14 joined directly to exon 16. These abnormally spliced mRNAs resulted from a G-->A transition at the +1 nucleotide of intron 15, which changed the invariant GT dinucleotide of the 5' donor splice site. That was associated with the activation of two cryptic donor splice sites in intron 15 and exon 15, respectively, and the use of an alternative splicing leading to the skipping of exon 15. Northern blot analysis showed that the overall content of these aberrantly spliced mRNAs in proband fibroblasts was one-fourth that found in control cells. These abnormally spliced mRNAs are predicted to encode three abnormal receptor proteins: the first would contain an insertion of 30 novel amino acids; the second would be a truncated protein of 709 amino acids; the third would be devoid of the 57 amino acids of the O-linked sugar domain. Ligand blot experiments indicated that the amount of LDL-receptor present in proband's fibroblasts was approximately one-tenth that found in control cells.


Subject(s)
Hyperlipoproteinemia Type II/genetics , Point Mutation , RNA Splicing , Receptors, LDL/genetics , Base Sequence , Blotting, Northern , Blotting, Southern , Child , DNA, Complementary/chemistry , Exons , Humans , Iodine Radioisotopes , Italy , Lipoproteins, LDL/metabolism , Male , Molecular Sequence Data , Polymerase Chain Reaction , Polymorphism, Single-Stranded Conformational , Promoter Regions, Genetic , RNA, Messenger/metabolism , RNA-Directed DNA Polymerase , Receptors, LDL/metabolism
18.
Clin Exp Rheumatol ; 9 Suppl 6: 41-5, 1991.
Article in English | MEDLINE | ID: mdl-2060177

ABSTRACT

Deflazacort, a new glucocorticoid (DFZ) which has recently become available, is known to have lower adverse effects on the skeletal metabolism and is expected to inhibit growth to a lesser extent in long-term treated children than earlier cortisone analogues. With the aim of verifying this hypothesis a multicenter study was planned to compare the effects of deflazacort and prednisone on linear growth and skeletal maturation in a group of prepubertal children requiring chronic steroid therapy. The data presented in this interim analysis refer to 24 children (11 females and 13 males ranging in age from 2.4 to 11.8 yrs) with rheumatoid arthritis (18), systemic lupus erythematosus (4) or dermatomyositis, selected from the total sample of 65 subjects included in the trial. They were randomly allocated to DFZ or PDN treatment and received the minimum effective dose of either steroid for at least 6 months per year. Longitudinal height measurements were obtained with standard instruments and techniques, and the bone age was assessed according to Greulich and Pyle. The following indicators of growth retardation were considered: bone age delay (difference between bone age and chronological age), statural age delay (statural age, with respect to the 50th percentile minus the chronological age) and statural age loss (statural age with respect to the individual height percentile at the first observation minus the chronological age).(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Body Height , Bone Development , Prednisone/therapeutic use , Pregnenediones/therapeutic use , Puberty , Rheumatic Diseases/physiopathology , Age Determination by Skeleton , Anti-Inflammatory Agents/therapeutic use , Child , Child, Preschool , Connective Tissue Diseases/pathology , Connective Tissue Diseases/physiopathology , Female , Growth , Humans , Infant , Male , Rheumatic Diseases/pathology
19.
Minerva Pediatr ; 42(7-8): 291-6, 1990.
Article in Italian | MEDLINE | ID: mdl-2274006

ABSTRACT

A comparative study as carried out between skin-fold thickness tests and bioelectric impedance analysis (BIA) to assess the validity of the latter as a method for evaluating body composition in childhood and youth. The percentage values of total body fat obtained using both methods in 117 boys and girls aged between 8 and 14 appear to be significantly correlated (p less than 0.01) in both sexes (males: r = 0.891; females: r = 0.830) and in each group of subjects subdivided according to stage of puberal development (8-11 years: r = 0.905; 12-14 years: r = 0.864) or the degree of physical activity performed (active: r = 0.880; sedentary: r = 0.915). The results of the study confirm that BIA represents a valid and reliable method to analyse body composition even during circumpuberal development in phase opposition. Moreover, BIA provides an estimate of total body fat which is independent of the differences in distribution between surface and deep deposits.


Subject(s)
Body Composition , Electric Conductivity , Skinfold Thickness , Adipose Tissue , Adolescent , Age Factors , Body Height , Body Weight , Child , Female , Humans , Male , Sex Factors
20.
Eur J Pediatr ; 149(5): 314-7, 1990 Feb.
Article in English | MEDLINE | ID: mdl-2311626

ABSTRACT

Modified Greulich-Pyle (GP), Tanner et al. 2, radius, ulna and short bones (TW2-RUS), TW2-20-bone and Roche-Wainer-Thissen RWT (knee) skeletal age assessments were made in an Italian population sample of 128 males and 93 females aged 4.1-16.9 years. All the scales appear to be well-suited to the Italian population despite minor differences. A very high correlation was found between the assessment of knee skeletal ages by the RWT method and that of the hand-wrist by the GP and TW2 systems in the same subject without sex and age-associated variations.


Subject(s)
Age Determination by Skeleton , Adolescent , Bone Development , Child , Child, Preschool , Female , Hand/growth & development , Humans , Italy , Knee/growth & development , Male , Methods , Wrist/growth & development
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