ABSTRACT
A hiperplasia endotelial intravascular ou tumor de Masson é uma lesão vascular benigna que não possui patogênese bem definida. Acredita-se que a resposta à lesão dos vasos sanguíneos seja um dos principais motivos para o seu desenvolvimento. É uma lesão tipicamente indolor, única e de evolução lenta. O objetivo deste relato é descrever um caso de tumor de Masson em uma região não habitual, na matriz ungueal do hálux, e discutir suas principais características
Intravascular endothelial hyperplasia, or Masson's tumor, is a benign vascular lesion with no well-defined pathogenesis. The response to vascular damage is believed to be one of the main reasons for its development. It is a typically painless injury, solitary, with slow evolution. This report aims to describe a case of Masson's tumor in an unusual place, the hallux nail matrix, and discuss its main characteristics.
ABSTRACT
BACKGROUND: Striae distensae (SD), an unsightly cutaneous condition characterized by epidermal atrophy, can affect the quality of life of women. OBJECTIVES: The aim of our study was to compare the efficacy of a neodymium:yttrium-aluminum-perovskite 1340 nm non-ablative fractional laser (NAFL) and the microneedling (MN) technique to treat striae alba (SA). MATERIALS AND METHODS: NAFL and MN were used to treat striae on the longitudinally divided abdominal surface of 20 women classified as Fitzpatrick skin type III or IV (five sessions at monthly intervals). Photographs and skin biopsies were obtained during pretreatment and after the third and fifth treatment sessions for all patients. Patients and two independent evaluators assessed the clinical response using the Global Aesthetic Improvement Scale. RESULTS: Patient-reported evaluation showed improvement of striae using both modalities, with no statistically significant difference between the groups. Collagen and elastic fibers were significantly increased (p < 0.01) after the third and fifth treatment sessions, with no significant difference between the modalities. In addition, Dermatology Life Quality Index scores showed significant improvement (p < 0.001) after the third and fifth treatment sessions compared with pretreatment values, with average values of 8.4 (standard error [SE] ± 1.21), 3.17 (SE ± 0.55), and 2.64 (SE ± 0.60), respectively. The mean pain score using the Visual Analog Scale in the MN group versus the NAFL group was 5.23 (SE ± 0.31) versus 2.39 (SE ± 0.22) [p < 0.001], and the mean duration of adverse events in the NAFL group versus the MN group was 4.03 days (SE ± 0.45) versus 3 days (SE ± 0.37) [p = 0.02]. CONCLUSION: NAFL and MN are safe for treating SD, particularly in individuals classified as phototype III or IV. MN is a useful non-technology-dependent, low-cost alternative therapy for SA. CLINICAL TRIAL REGISTRATION NUMBER: NCT03390439.
Subject(s)
Cosmetic Techniques , Lasers, Solid-State/therapeutic use , Needles , Striae Distensae/therapy , Adult , Biopsy , Collagen/metabolism , Female , Humans , Quality of Life , Striae Distensae/pathology , Treatment OutcomeABSTRACT
O sarcoma congênito da família Ewing é uma doença extremamente rara, que se manifesta através do surgimento de uma massa e sinais sistêmicos como dor e febre. Cerca de 70 a 80% dos casos ocorrem antes dos 20 anos de idade. Histologicamente se caracteriza pela presença de pequenas células arredondadas e azuis. Além disso, pode se manifestar em tecidos moles ou osso e em qualquer parte do corpo, sendo a forma congênita mais comumente encontrada nas extremidades. O diagnóstico é estabelecido através de exames de imagem, histopatologia e imuno-histoquímica. Esses tumores costumam ser agressivos e apresentar elevada mortalidade. Aqui, relatamos o caso de um recém-nascido que apresentou uma massa no membro superior esquerdo diagnosticada como sarcoma congênito da família Ewing por biópsia cutânea por punch e pela presença do marcador CD99 (AU)
Congenital Ewing's sarcoma is an extremely rare disease, manifested by the appearance of a mass and systemic signs such as pain and fever. About 70-80% of cases occur before 20 years of age. This condition is histologically characterized by the presence of small round blue cells and can manifest in bone or soft tissue, anywhere in the body, with the congenital form being the most commonly found in the extremities. The diagnosis is established by imaging, histopathology, and immunohistochemistry. These tumors tend to be aggressive and have high mortality rates. Here, we report the case of a newborn who presented a mass in the left upper limb diagnosed as congenital Ewing's sarcoma by punch skin biopsy and the presence of the CD99 marker (AU)
Subject(s)
Humans , Male , Infant, Newborn , Sarcoma, Ewing/congenital , Bone Neoplasms/congenital , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Neuroectodermal Tumors, Primitive, Peripheral/congenital , Sarcoma, Ewing/diagnostic imaging , Sarcoma, Ewing/pathologyABSTRACT
O crescimento do número de pessoas idosas foi acompanhado por um aumento de comorbidades geradoras de imobilidade e de institucionalização. Objetivamos identificar as variáveis associadas à imobilidade e à realização das atividades básicas da vida diária (AVDs) em uma Instituição de Longa Permanência (ILPI). A média etária das idosas institucionalizadas foi de 72,8 anos, sendo 40,3% dependentes quanto a AVDs. Os fatores associados à imobilidade foram: doenças reumatológicas, gastrointestinais e incontinência urinária (p<0,05).(AU)
The increasing number of elderly has growth the prevalence of comorbidities that generate immobility and of institutionalization. We aimed identify the variables associated with immobility and performingbasic activities of daily living (AVD) on a ILP. The average age of institutionalized elderly was 72.8 years and 40.3% were dependent about the AVDs.The factors associated with immobility were: rheumatic diseases, gastrointestinal and urinary incontinence (p <0.05).(AU)
Subject(s)
Humans , Aged , Aged , Immobilization , Institutionalization , Homes for the AgedABSTRACT
O crescimento do número de pessoas idosas foi acompanhado por um aumento de comorbidades geradoras de imobilidade e de institucionalização. Objetivamos identificar as variáveis associadas à imobilidade e à realização das atividades básicas da vida diária (AVDs) em uma Instituição de Longa Permanência (ILPI). A média etária das idosas institucionalizadas foi de 72,8 anos, sendo 40,3% dependentes quanto a AVDs. Os fatores associados à imobilidade foram: doenças reumatológicas, gastrointestinais e incontinência urinária (p<0,05).
The increasing number of elderly has growth the prevalence of comorbidities that generate immobility and of institutionalization. We aimed identify the variables associated with immobility and performingbasic activities of daily living (AVD) on a ILP. The average age of institutionalized elderly was 72.8 years and 40.3% were dependent about the AVDs.The factors associated with immobility were: rheumatic diseases, gastrointestinal and urinary incontinence (p <0.05).
Subject(s)
Humans , Aged , Aged , Homes for the Aged , Immobilization , InstitutionalizationABSTRACT
Polyamines, including spermidine, facilitate seizures by positively modulating N-methyl-d-aspartate receptors (NMDAr). Although NMDAr antagonists decrease seizures, it remains to be determined whether traxoprodil, a selective antagonist at the NR2B subunit of the NMDAr, decreases seizures and whether spermidine facilitates pentylenetetrazol (PTZ)-induced seizures. Adult male Wistar rats were injected in the lateral ventricle with 0.9% NaCl (1µl, i.c.v.), spermidine (0.02, 0.2 or 2nmol/site, i.c.v.) or traxoprodil (0.2, 2 or 20nmol, i.c.v.) and with PTZ (35 or 70mg/kg, i.p.). The effect of orally administered traxoprodil (60mg/kg, p.o.) on seizures was also investigated. Latencies to clonic and generalized seizures, as well the total time spent in seizures were recorded by behavioral and electrographic methods (EEG). Spermidine (2nmol/site; i.c.v.) facilitated the seizures induced by a sub-threshold dose of PTZ (35mg/kg; i.p.), but did not alter seizure activity induced by a convulsant dose of PTZ (70mg/kg; i.p.). Traxoprodil (20nmol i.c.v.) increased the latency to generalized tonic-clonic seizures induced by PTZ (70mg/kg; i.p.). Traxoprodil (60mg/kg, p.o.) increased the latency to clonic and generalized seizures, and decreased the total time spent in seizures. These results support the role for the NR2B subunit in PTZ-induced seizures.
