ABSTRACT
Nephrogenic ascites is a complex problem with a poorly understood pathophysiology. We report the case of a patient with nephrogenic ascites and concomitant secondary hyperparathyroidism who was resistant to the usual treatment but had a complete resolution after subtotal parathyroidectomy. We believe that secondary hyperparathyroidism might be implicated in the pathogenesis of nephrogenic ascites.
Subject(s)
Ascites/etiology , Hyperparathyroidism, Secondary/complications , Kidney Failure, Chronic/complications , Adult , Humans , Hyperparathyroidism, Secondary/blood , Hyperparathyroidism, Secondary/surgery , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/therapy , Male , Parathyroidectomy , Renal DialysisABSTRACT
PIP: The effects of the oral contraceptive pill on th blood and urinary levels of various hormones was studies using 5 groups of women. Group 1 consisted of 59 women using combined contraceptive pills for 1 to 12 years under the commercial names of primovlar (25 cases) Anovlar (19 cases) and Ovral (15) cases; group 2 consisted of 50 pregnant women during the 1st trimester; group 3 consisted of 50 pregnant women during th 2nd trimester; group 4 consisted of 50 pregnant women during the 3rd trimester and group 5 was the control group consisting of 10 fertile nonpregnant women. Triiodothynine (T3) and throxine (T4) were determined in the sera of 59 women using combined contraceptive pills (estrogen 0.05 mg and progestogen 0.5 mg/pill), 150 pregnant women during the 1st, 2nd and 3rd trimesters and 10 normal fertile women used as controls. There were marked differences in the value of thyroid function tests in the euthyroid nonpregnant and euthyroid pregnant women. The effect of contraceptive pills coincided with the effect of pregnancy during the 3rd trimester. The protein bound iodine (PBI) shows insignificant increase during the 1st and 2nd trimester, while significant increase has been found during the 3rd trimester and in contraceptive pill users, p0.05. Total serum thyroxine shows insignificant increase occurred during the 3rd trimester and in contraceptive pill users. Thyro-binding Index showed no change than normal control during the first, second and third trimesters, while a nonsignificant increase has been found in contraceptive pill users, p0.05% uptake of T3 is not changed during the 1st and 2nd trimesters, while a decrease has been noticed in contraceptive pill users (21.8%) and a slight decrease occurred during 3rd trimester(27.9%) compared to the normal nonpregnant group^ieng
Subject(s)
Blood , Contraception , Contraceptive Agents, Female , Contraceptives, Oral , Hormones , Pregnancy , Research Design , Thyroid Gland , Time Factors , Africa , Africa, Northern , Biology , Clinical Laboratory Techniques , Contraceptive Agents , Contraceptives, Oral, Combined , Contraceptives, Oral, Hormonal , Demography , Developing Countries , Egypt , Endocrine Glands , Endocrine System , Estrogens , Ethinyl Estradiol , Family Planning Services , Hematologic Tests , Metabolism , Middle East , Norgestrel , Physiology , Population , Population Dynamics , Progesterone , Reproduction , ResearchABSTRACT
PIP: Potential adjuvants for use in immunizing women against beta hCG (beta-chain human chorionic gonadotropin) for contraception were tested in mice for their trapping effect: trapping refers to the sequestation of lymphocytes in the draining lymph node after immunization. The substances tested were Freund's complete adjuvant (FCA) as a positive control, Corynebacterium parvum, tetanus toxoid as a carrier protein for beta-hCG, hCG, beta-hcg-tetanus toxoid conjugate + C. parvum, and saline as a negative control. FCA is unsuitable for human use. Female mice were injected in the left food pad and the popliteal lymph nodes were studied histologically at 4 and 8 days. Tetanus toxoid induced enlargement and blast cell formation at 8 days. Fca caused enlargement and blast cell transformation at 4 days and marked enlargement and formation of germinal centers at 8 days. C. Parvum evoked a similar response to FCA, with slight enlargement of the right lymph nodes at Day 8. hCG brought no response except for slight enlargement at 8 days. The combined beta-hCG-tetanus toxoid + C. parvum elicited the greatest response, enlargement, hypercellular paracortex, blast cell transformation at 4 days and numerous germinal centers at 8 days, with enlargement of the contralateral nodes also. Since, neither tetanus toxoid nor beta-hCG causes trapping, the use of C. parvum as an adjuvant is suggested to enhance women's immune response to beta-hCG.^ieng
Subject(s)
Animals, Laboratory , Chorionic Gonadotropin , Contraception, Immunologic , Contraception , Immunity , Tetanus , Africa , Africa, Northern , Biology , Developing Countries , Disease , Egypt , Endocrine System , Family Planning Services , Gonadotropins , Hormones , Infections , Middle East , Physiology , ResearchABSTRACT
Impetigo contagiosa in Cairo affected young children of both sexes, the face being the main site. Post-impetigo nephritis, confirmed by a low serum C3 level and by urinalysis, occurred in only 11% of cases. Streptococcus pyogenes strains were recovered from 84% of the skin lesions. Sixteen types were identified according to their T-protein, and most infections were associated with T3/B3264, T13/B3264, T5, T11, T12, T8/25/Imp 19 and T14/49; the majority of these types were also recovered from houseflies. The types isolated from cases of post-impetigo nephritis were T4 (M 60), T14/49 (M49), T8/25/Imp 19 (mostly M 55) and T11. Seventy percent of the patients infected with T4 (M 60) and 40% of those infected with T14/49 (M 49) developed nephritis. Strains isolated from the skin bore a closer resemblance to those isolated from the nose than to those found in the throat. The ASO response was poor in uncomplicated impetigo but the titre rose more aften in post-impetigo nephritis.
Subject(s)
Glomerulonephritis/microbiology , Impetigo/microbiology , Acute Disease , Antistreptolysin/analysis , Child , Child, Preschool , Complement C3/analysis , Egypt , Female , Glomerulonephritis/immunology , Humans , Impetigo/immunology , Male , Streptococcus pyogenes/isolation & purificationABSTRACT
Three Staphylococcus epidermidis strains produced a factor giving rise to opacity in different sera but not in albumin. Serum opacity factor was resistant to age and heat and active in acidic media.
