Measurement of Isfahan heavy water zero-power reactor kinetic parameters using advanced pulsed neutron source method in a near critical state.

The pulsed neutron source (PNS) technique was used to determine the prompt neutron decay constant for two different lattice pitches in the HWZPR heavy water zero power reactor. The results were compared to the variance-to-mean ratio (VTM) method. The neutron mean generation time was also calculated for both pitches, and the results were compared to previous Monte Carlo calculations. The findings of this research can be used as a benchmark nuclear codes to validate kinetic parameters.

Pharmacist-driven antimicrobial stewardship interventions in patients with COVID-19: a scoping review.

BACKGROUND: Coronavirus Disease 2019 (COVID-19) is a highly infectious disease that can be treated with antivirals in addition to other antimicrobials in cases of secondary or concomitant infections. This creates potential for antimicrobials misuse, which increases antimicrobial resistance (AMR). Pharmacists are known to undertake prominent roles in combatting AMR. AIM: The aim of this review was to characterize pharmacist-driven interventions that have been performed in patients with COVID-19 globally and describe their impact on antimicrobial use. METHOD: We followed the Joanna Briggs Institutes manual framework for scoping reviews in our study. Studies that reported antimicrobial stewardship (AMS) interventions performed by pharmacists in COVID-19 patients were included. Articles that did not report outcomes or did not mention pharmacists in the intervention were excluded. Restrictions included English-only articles from inception date until June 2022. Articles were searched from four databases. RESULTS: Eleven publications were included in the review. The most common AMS intervention was pharmacist-driven interventions reported in 63.2% of all studies, followed by guideline development and application (26.3%), and medication supply coordination (10.5%), respectively. The outcomes of the interventions were difficult to compare but showed a reduction in antimicrobial use and prevention of adverse drug reactions with a relatively high acceptance rate from physicians. CONCLUSION: Pharmacists played an important role in performing AMS-related interventions in COVID-19 patients and helped in the fight against the worsening of AMR during the pandemic. The impact of pharmacist-driven AMS interventions in patients with COVID-19 seemed to be positive and improved outcomes related to antimicrobial use.

eIF4F suppression in breast cancer affects maintenance and progression.

Levels of eukaryotic initiation factor 4E (eIF4E) are frequently elevated in human cancers and in some instances have been associated with poor prognosis and outcome. Here we utilize transgenic and allograft breast cancer models to demonstrate that increased mammalian target of rapamycin (mTOR) signalling can be a significant contributor to breast cancer progression in vivo. Suppressing mTOR activity, as well as levels and activity of the downstream translation regulators, eIF4E and eIF4A, delayed breast cancer progression, onset of associated pulmonary metastasis in vivo and breast cancer cell invasion and migration in vitro. Translation of vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP9) and cyclin D1 mRNAs, which encode products associated with the metastatic phenotype, is inhibited upon eIF4E suppression. Our results indicate that the mTOR/eIF4F axis is an important contributor to tumor maintenance and progression programs in breast cancer. Targeting this pathway may be of therapeutic benefit.

[Isolated radiocarpal luxation. A case report and general review of the literature]. / La luxation radio-carpienne pure. A propos d'un cas et revue générale de la littérature.

PURPOSE OF THE STUDY: We describe a case of an isolated radiocarpal dislocation and review the literature. CASE REPORT: A young 29-year-old male, suffering from a wrist injury after a motor cycle accident, was diagnosed as dorsal radiocarpal joint dislocation with distal radioulnar dislocation and no fracture, close reduction was immediately performed followed by plaster cast immobilisation. After five months satisfactory stability and motion were obtained without signs of carpal instability. DISCUSSION: This pathology is exceptional with less than 15 published cases. Dislocation is due to wrist hyperextension with ulnar motion but without, probably, intracarpal supination. After immediate treatment, this lesion appeared to have a good prognosis without post-traumatic carpal instability, when compared to the poorer result of perilunar dislocation.

[Modular construction (2 HS-1 SH), using Cotrel-Dubousset's universal instrumentation for comminuted fractures of the thoracolumbar junction. Comparison with various other constructions]. / Le montage "intermédiaire" (2 CV-1 VC) par l'instrumentation "universelle" de Cotrel-Dubousset pour les fractures comminutives de la jonction thoraco-lombaire. Comparaison avec une série de montages variés.

INTRODUCTION: The authors' objective was to study the anatomical and functional results of an original construct using the Cotrel-Dubousset instrumentation. MATERIAL AND METHODS: This construct is called "Modular construct" or "2 H.S.-1 S.H." fits up two vertebrae above the fracture and a single below. So if the fracture is situated on the L1 level, a supra-laminar hook is set up on each side of T11, and two pedicular screws in T12 (2 H.S.). In the same way, a pedicular screw and an infra-laminar hook are set up on each side of L2 (1.S.H.). Two transverse bars connect together the right and the left rod. This retrospective work is based on the study of 24 patients who had a Thoraco-lumbar burst fracture according to Denis'classification, who were operated on in our Department, and started again to walk without external contention. All the patients had a postero-lateral bone graft. There were no [corrected] anterior arthrodesis performed. The average follow up was 4 years. This series was compared with a concomitant series of miscellaneous constructs realized by the same operators with the C.D. instrumentation. RESULTS: The average regional kyphosis angles went from 16.9 degrees in pre-operative to 3.9 degrees in post-operative, and 8 degrees at the maximum follow up. The average vertebral kyphosis angles went from 18 degrees in pre-operative to 3.8 degrees in post-operative, and 6.3 degrees at the maximum follow up. The miscellaneous constructs had poorer results. There were two severe infections, one early the other late. DISCUSSION: These results compared with the literature show that the 2 H.S.-1 S.H. construct is a competitive one. We think that its mechanical qualities arise from adding systematically hooks at the ends of the construct. These hooks protect the screws during flexion and from pull out constraints.

Sexualidad y sexismo bajo el capitalismo

Se ha considerado necesario reubicar el problema de la sexualidad y el sexismo para su estudio en psicología, en el terreno de lo político, lo social y lo económico. A tales efectos se realiza un estudio de la diferenciación jerarquizada de los papeles asignados a los individuos en razón del sexo a que pertenecen y a las características socio-económicas de una sociedad dada. Luego del análisis de las condiciones materiales que impiden la transformación de esta situación bajo el capitalismo, así como aquellas que en el socialismo permiten la transformación de la condición humana en general y, en especial, de la emancipación de la mujer, se concluye que la lucha de las mujeres es también la lucha de todos los obreros contra el enemigo común: el capital (AU)