Emotional information processing in young and older adults: meta-analysis reveals faces elicit distinct biases.

Although a number of empirical studies have found support for distinct emotional information processing biases in young versus older adults, it remains unclear whether these biases are driven by differential processing of positive or negative emotional information (or both) and whether they are moderated by stimulus type, in particular face versus non-face, the former of which is known to be subject to distinct processing. To address these gaps in the literature, our analyses included 2237 younger (mean age = 21.61 years) and 2136 older (mean age = 70.58 years) adults from 73 data sets, 19 involving face stimuli and 54 involving non-face stimuli (objects or scenes). Our findings indicated a significant overall age-related positivity effect (Hedge's g = 0.35) when comparing positive and negative stimuli, but consideration of emotionally neutral stimuli revealed significant age differences in emotional processing for negative stimuli only, with younger adults showing a stronger negativity bias. Furthermore, compared to emotionally neutral stimuli, both younger and older adults showed evidence of biases toward non-face positive and negative stimuli and toward positive but not negative face stimuli. Thus, although the present meta-analysis found evidence of an overall age-related positivity effect consistent with a shift toward positivity with aging, a different picture emerged when comparing emotional against neutral stimuli, and consideration of stimulus type revealed a distinct pattern for face stimuli, which may reflect the biological and social significance of facial expressions. Supplementary Information: The online version contains supplementary material available at 10.1007/s10433-021-00676-w.

Effects of a Brief Stair-Climbing Intervention on Cognitive Functioning and Mood States in Older Adults: A Randomized Controlled Trial.

Despite an abundance of evidence that exercise benefits cognition and mood, physical activity levels among older adults remain low, with time and inaccessibility posing major barriers. Interval stair climbing is an accessible time-efficient form of physical activity demonstrated to benefit cognition and mood in young adults, but effectiveness in older adults remains unknown. To address this, 28 older adults (Mage = 69.78 years, 16 females) undertook cognitive and mood assessments twice, 1 week apart, once preceded by interval stair climbing. A fairly large, albeit only marginally significant, effect size (ηp2=.12) indicated improved cognition following the moderate- to high-intensity intervention; however, rather than improving mood, older adults reported feeling more tired (g = 0.51). These outcomes provide initial indications that this mode of exercise that can easily translate to naturalistic settings offers promise as an intervention strategy, but more research is needed to optimize the protocol to suit aged populations (ACTRN1261900169014).

Investigation of the complex structure, comparative DNA-binding and DNA cleavage of two water-soluble mono-nuclear lanthanum(III) complexes and cytotoxic activity of chitosan-coated magnetic nanoparticles as drug delivery for the complexes.

Two water-soluble mono-nuclear macrocyclic lanthanum(III) complexes of 2,6-diformyl-4-methylphenol with 1,3-diamino-2-propanol (C1) or 1,3-propylenediamine (C2) were synthesized and characterized by UV-Vis, FT-IR, 13C and 1H NMR spectroscopy and elemental analysis. C1 complex was structurally characterized by single-crystal X-ray diffraction, which revealed that the complex was mononuclear and ten-coordinated. The coordination sites around lanthanum(III) were occupied with a five-dentate ligand, two bidentate nitrates, and one water molecule. The interaction of complexes with DNA was studied in buffered aqueous solution at pH7.4. UV-Vis absorption spectroscopy, emission spectroscopy, circular dichroism (CD) and viscometric measurements provided clear evidence of the intercalation mechanism of binding. The obtained intrinsic binding constants (Kb) 9.3×103 and 1.2×103M-1 for C1 and C2, respectively confirmed that C1 is better intercalator than C2. The DNA docking studies suggested that the complexes bind with DNA in a groove binding mode with the binding affinity of C1>C2. Moreover, agarose gel electrophoresis study of the DNA-complex for both compounds revealed that the C1 intercalation cause ethidium bromide replacement in a competitive manner which confirms the suggested mechanism of binding. Finally, the anticancer experiments for the treated cancerous cell lines with both synthesized compounds show that these hydrophilic molecules need a suitable carrier to pass through the hydrophobic nature of cell membrane efficiently.

The Relationship between Obsessions and Compulsions and Negative and Positive Symptoms in Schizophrenia.

OBJECTIVE: The aim of the present study is to investigate the relationship between obsessive-compulsive symptoms (OCSs) and negative and positive symptoms in schizophrenia. METHODS: Subjects of the study comprised of 31 schizophrenia with obsessive-compulsive symptoms (19 men and 12 women) selected by convenience sampling method from Iran psychiatric Hospital. The diagnoses were established on the basis of DSM-IV-TR. The required data were obtained using Positive and Negative Syndrome Scale (PANSS) and Yale-Brown Obsessive-Compulsive scale (Y-BOC). RESULTS: The results of multiple regression analysis indicated that obsessive symptoms inversely predict negative symptoms. In other words, as the obsessive symptoms increase, the negative symptoms of schizophrenia decrease. Nevertheless, no significant relationship was found between OCSs and positive symptoms. CONCLUSION: This study reveals that OCSs exert a protective effect on schizophrenia and do not necessarily cause poorer prognosis.