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1.
J Pharm Bioallied Sci ; 9(Suppl 1): S187-S190, 2017 Nov.
Article in English | MEDLINE | ID: mdl-29284961

ABSTRACT

BACKGROUND: The transalveolar extraction and the use of pharmacological antibiotic therapy following the surgical procedure in management of postoperative infection go hand in hand in minor oral surgery. Attention has often been focused on antibiotic therapy administered at different time schedules (before or after surgery or both). This investigation reveals how the use of different molecules and dosages is critical in the postoperative period and has always provided positive result. METHODOLOGY: A prospective randomized study was carried out in 100 healthy controls of age group 20-50 years undergoing transalveolar extraction in the Department of Oral and Maxillofacial Surgery, Vivekanandha Dental College for Women. A 5-day regimen of amoxicillin or ciprofloxacin group of antibiotics along with regular analgesics was administered to the patients following transalveolar extraction. The patients were evaluated for postoperative infection, inflammation and wound care on postoperative days: day zero, day 2, day 5, day 7, day 15, day 30, and analyzed. A P < 0.05 was considered statistically significant. RESULTS AND CONCLUSION: A total of 100 patients aged 23-50 years (24.6-4.43) met the inclusion criteria. Male accounted for 44, while female were 55, giving male:female ratio 1:1.4. Postoperative infection was minimum with ciprofloxacin group as compared to amoxicillin group and was more significant (P < 0.005) on evaluation. A complete review has also been taken into an account, various strategies used such as surgical flaps, no traumatic osteotomy, and primary or secondary closure.

2.
Clin Nephrol ; 83(2): 121-3, 2015 Feb.
Article in English | MEDLINE | ID: mdl-24361058

ABSTRACT

Enzymatic creatinine assays are considered superior to Jaffe assays due to greater analytical specificity. We report a case of phenindione interference with an enzymatic assay resulting in significant misclassification in a patient with chronic kidney disease (CKD). Analysis of creatinine values of a further 36 patients who were treated with phenindione showed significant negative interference of phenindione with the Roche enzymatic creatinine assay.


Subject(s)
Creatinine/blood , Enzyme Assays/methods , Phenindione/adverse effects , Renal Insufficiency, Chronic/diagnosis , Anticoagulants/administration & dosage , Anticoagulants/adverse effects , Anticoagulants/blood , Diagnostic Errors , Glomerular Filtration Rate , Humans , Male , Middle Aged , Phenindione/administration & dosage , Phenindione/blood , Renal Insufficiency, Chronic/physiopathology
3.
J Pharm Bioallied Sci ; 5(Suppl 2): S135-8, 2013 Jul.
Article in English | MEDLINE | ID: mdl-23956591

ABSTRACT

A dentigerous cyst is an odontogenic cyst associated with the crown of the impacted or unerupted teeth. Such cyst remain initially completely asymptomatic unless when infected and can be discovered only on routine radiographic examination. Here, such a case of dentigerous cyst, which was discovered on routine radiographic examination, is discussed here.

4.
J Pharm Bioallied Sci ; 5(Suppl 2): S142-6, 2013 Jul.
Article in English | MEDLINE | ID: mdl-23956593

ABSTRACT

Cherubism was first described by Jones in 1933 as "familial multilocular cystic disease of jaws." Renamed as cherubism in 1938 because of classical characteristics of full round cheeks and upward cast of the eyes to the angelic look of the cherubs immortalized by renaissance art. It is characterized by progressive painless bilateral swelling of jaws involving either maxilla or mandible producing chubby face. It is uncommon fibro-osseous disorder of bone. Mutation in the gene encoding SH3-binding protein 2 (SH3BP2) plays a role in the disease. There are indications that the gene SH3BP2 plays a role in regulating the increased osteoblast and osteoclast activities that are seen in normal tooth eruption and point mutations in the gene could cause pathologic activation of osteoclasts. The purpose of this paper is to present the uncommon form of cherubism and to review the clinicoradiographic, histopathologic features and treatment so as to facilitate diagnosis of disease.

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