[Efficiency of mexidol during perinatal encephalopathy in early age children].

We have investigated 200 patients 0-4 months of age (boys 110 and girls - 90), 120 of them under 1 month of age and 80 children from 1 to 4 months. The evaluation of the neurologic status of patients was performed 40-60 minutes after feeding in a relaxed condition. From the additional methods of the investigation of the nervous system, the most informative was the neurosonoscopy. We have divided patients into two groups according to the clinical syndromes: I gr. neuro-reflexion irritation syndrome (118 patients), II gr.--depression syndrome (82 patients). According to the treatment regimen patients also have been divided into two groups: the basic group (104 patients) with treatment only by mexydol (mexydol in a dose of 5 mg/kg and 0,3 ml in the form of injections twice a day. Injections were initiated at the acute stage of the disease) and the control group (96 patients) with no treatment. Efficiency of mexidol was estimated comparison of the findings in the basic and control groups based both on a clinical status and on the neurosonoscopic findings. Positive dynamics was observed in patients of the basic group. Verification of mexydol efficiency was performed by neurosonoscopic investigations. In a small portion of patients positive dynamics was not observed. These patients were from the age group from 3 to 4 months, which confirms that earlier and optimal treatment contribute to the prevention of severe neurological outcomes. It may be concluded that: 1. Mexydol acting on the pathogenetic mechanisms of perinatal encephalopathy, reduces reflexion irritation and depression syndromes both in neonatal and early age children. 2. Mexydol induces normalization of pathological neurosonoscopic patterns. 3. Mexydol with its wide pharmacological spectrum of action is an effective medicine in treatment of perinatal encephalopathy.

[A case of familial Marfan syndrome without manifested ocular anomalies]. / Semeinyi sluchai sindroma Marfana bez manifestatsii glaznykh anomalii.

Three sibs aged 14, 13 and 10 years are described. The Marfan's syndrome was inherited from their father. Full penetration and pseudovariable expressivity of the mutant gene were characteristic of the case. With pronounced phenotypic manifestations of the mutation inherited, the lack of typical ocular anomalies was evident.

[Value of the "startle" symptom in predicting the development of epileptic phenomena in infancy]. / Znachenie simptoma "ispuga" v prognozirovanii razvitiia épilepticheskikh fenomenov v mladencheskom vozraste.

This is the first description of the "startle reaction" observed in young children and of the technique of its stimulation. On the basis of the study of 38 children with the given symptom and of 30 control children aged up to 6 months the independence and pathologic nature of the startle reaction have been proved. 12-month follow-up of both groups has allowed the authors to draw up the conclusion about the prognostic significance of the symptom for the development of epileptic phenomena in children. A principle of preventive therapy for the prophylaxis of convulsive manifestations and reducing the duration of the anticonvulsive therapy is proposed.

[Course of Duchenne muscular dystrophy and its treatment]. / O techenii miodistrofii Diushenna i ee terapii.

The results of a 12 month follow-up of 3 groups of age-matched children (7 boys in each group) with an identically malignant course of Duchenne's myodystrophy determined by means of a genealogical analysis are presented. The fastest progression of the disease was observed in children receiving conventional treatment. Untreated children showed slower progression of the disease. In patients on allopurinol treatment the process was somewhat checked or there was some regression of symptomatology.