ABSTRACT
Central nervous system involvement is an uncommon complication of systemic non-Hodgkin lymphomas. The majority of these cases concern B-cell lymphomas. We report a case of systemic T-cell anaplastic large cell lymphoma CD30+ ALK- with CNS involvement at the time of diagnosis and unusual MRI characteristics resembling acute disseminated encephalomyelitis.
Subject(s)
Encephalomyelitis, Acute Disseminated/complications , Lymphoma, Large-Cell, Anaplastic/complications , Anaplastic Lymphoma Kinase , Brain/diagnostic imaging , Brain/pathology , Encephalomyelitis, Acute Disseminated/diagnostic imaging , Encephalomyelitis, Acute Disseminated/immunology , Encephalomyelitis, Acute Disseminated/pathology , Humans , Ki-1 Antigen/immunology , Lymphoma, Large-Cell, Anaplastic/diagnostic imaging , Lymphoma, Large-Cell, Anaplastic/immunology , Lymphoma, Large-Cell, Anaplastic/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Receptor Protein-Tyrosine Kinases/immunologyABSTRACT
Bilateral internuclear ophthalmoplegia has been linked with various pathological conditions of the central nervous system (CNS), such as multiple sclerosis, stroke, tumours, and brainstem inflammatory processes. Herein the authors report a case of a 45-year-old female patient who presented with diplopia due to bilateral internuclear ophthalmoplegia, with no evidence of brainstem lesion in brain magnetic resonance imaging (MRI) and was diagnosed with primary Sjögren's syndrome.
