ABSTRACT
In rats, administration of 96% ethanol to the stomach causes ulcerative damages to its mucosa just 8 minutes later, which are of significant dimensions, reaching their maximum size following 3 hours. The sydnonimine psychostimulant OF-743 in combination with ethanol substantially reduces mucosal damage. The use of ethanol after OF-743 injections results in less ulcerative damage. The findings suggest that the drug has not only protective (preventive) effects, but beneficial properties.
Subject(s)
Anti-Ulcer Agents/pharmacology , Antidepressive Agents/pharmacology , Sydnones/pharmacology , Animals , RatsABSTRACT
It has been revealed that OF 743, one of the psychostimulators belonging to phenylalkylsydnonimine derivatives, exerts anti-ulcerogenic action in case of stress- and ethanol-induced damage of gastric mucosa in rats. However OF 743 was not effective in case of indomethacin-induced gastric mucosal damage. Complex administration of OF 743 and arginine was accompanied by a considerable decrease of indomethacin-induced gastric mucosal damage. That combination was more effective than OF 743 alone in case of ethanol-induced gastric mucosal damage.
Subject(s)
Anti-Ulcer Agents/pharmacology , Antidepressive Agents/pharmacology , Arginine/pharmacology , Sydnones/pharmacology , Animals , Drug Therapy, Combination , Ethanol/antagonists & inhibitors , Gastric Mucosa/drug effects , Indomethacin , Male , Rats , Stress, Physiological/physiopathologyABSTRACT
Intragastric administration of 96% ethanol, 1 ml/100 g of body mass, induced ulcerous impairments of rat gastric mucosal membrane, which were marked within 8 min after ethanol administration and reached the maximal size within 3 hrs. Psychostimulants of the phenylalkyl sydnonimime series OF 743, administered after the ethanol treatment, decreased distinctly the ethanol-induced impairments of gastric mucosal membrane and this effect was higher in simultaneous inoculation of the drug and ethanol. The data obtained suggest that preparation OF 743 exhibited both protective and curative antiulcerogenic efficiency.
Subject(s)
Psychotropic Drugs/therapeutic use , Sydnones/therapeutic use , Ulcer/drug therapy , Animals , Ethanol/toxicity , Rats , Ulcer/chemically induced , Ulcer/prevention & controlABSTRACT
The possibility of the inhibitory influence of one of the psychostimulators of sydnonimine derivatives OF 743 on stress--and ethanol-induced mucosal lesions was studied in rats. Large doses (15 mg/kg) OF 743, which induced both central, psychostimulator, peripheral, and vagolytic effects equally decrease stress- and ethanol-induced mucosal lesions. The smaller doses, which show only peripheral effects, largely inhibit ethanol-induced lesions. The degree of the inhibitory influence of OF 743 is comparable with the same atropine influence and considerably exceeds the degree of the inhibitory influence of pirenzepine.
Subject(s)
Antidepressive Agents/pharmacology , Ethanol/adverse effects , Gastric Mucosa/drug effects , Parasympatholytics/pharmacology , Stomach Ulcer/prevention & control , Stress, Physiological/pathology , Sydnones/pharmacology , Animals , Atropine/pharmacology , Cold Temperature , Gastric Mucosa/pathology , Immobilization , Male , Pirenzepine/pharmacology , Rats , Stomach Ulcer/chemically induced , Stomach Ulcer/etiologyABSTRACT
Mucosal gastric damages in rats induced by intragastric ethanol introduction decreased considerably on the background of action of one of the antidepressants (asaphen, inkasan and OF-743) in combination with arginine. The combination OF-743 with arginine has the largest protective action, the least one--asaphen with arginine. A comparison of protective action of some antidepressants with action of antidepressants in combination with arginine revealed a tendency to more expressed antiulcerogenic effect in studied combinations.