Subject(s)
Dental Enamel Hypoplasia/diagnosis , Amelogenesis Imperfecta/diagnosis , Amelogenesis Imperfecta/etiology , Amelogenesis Imperfecta/therapy , Child , Child, Preschool , Cross-Sectional Studies , Dental Caries/diagnosis , Dental Caries/epidemiology , Dental Caries/etiology , Dental Caries/therapy , Dental Enamel Hypoplasia/epidemiology , Dental Enamel Hypoplasia/etiology , Dental Enamel Hypoplasia/therapy , Fluorosis, Dental/diagnosis , Fluorosis, Dental/epidemiology , Fluorosis, Dental/etiology , Fluorosis, Dental/therapy , Humans , Infant , Risk Factors , Tooth Injuries/complications , Tooth Injuries/diagnosisABSTRACT
Dihydropyrimidine deshydrogenase (DPD) is the rate limiting enzyme of 5-fluorouracil (5-FU) catabolism and its activity is generally determined in peripheral blood mononuclear cells. Several studies have highlighted interactions between toxicities to 5-FU and a DPD activity deficiency. Circadian variations in 5-FU anabolism enzymes are suggested. Circadian variations in 5-FU catabolism enzymes, and especially for DPD in healthy subjects or patients, have shown in some cases circadian variations in DPD activity but with different peak times. Based on this knowledge, chronomodulated therapy for the association 5-FU-folinic acid with maximal delivery rate in the first half of the night was shown clearly to be 5 times less toxic than control flat therapy. Nevertheless, in the most active chronotherapy pattern, 30% of the patients have also toxicities. However the timing of the individual peak of DPD activity remains controversial.
Subject(s)
Circadian Rhythm , Dihydrouracil Dehydrogenase (NADP)/metabolism , Fluorouracil/pharmacokinetics , Biotransformation , Humans , Kinetics , Leukocytes, Mononuclear/enzymologyABSTRACT
This case report describes the esthetic management of a dental trauma at the first visit and its subsequent treatments to restore the esthetics and function. Today, patients expect adequate esthetics and the ability to confidently smile immediately after the first appointment. In addition, they require that esthetics is maintained throughout the definitive treatment phase as well. After the use of the fractured crown as a temporary replacement crown, an orthodontic extrusion was undertaken to restore the physiological periodontal attachment. The tooth was then splinted for 6 months and at completion of this orthodontic stage, the permanent restoration was fabricated.
Subject(s)
Incisor/injuries , Tooth Crown/injuries , Tooth Fractures/therapy , Tooth Root/injuries , Adult , Combined Modality Therapy , Crowns , Dental Prosthesis Design , Esthetics, Dental , Follow-Up Studies , Humans , Male , Post and Core Technique , Root Canal Therapy , Tooth Movement TechniquesABSTRACT
In spite of a spectacular drop of dental caries in children during the last ten years, the young child polycaries syndrome has not disappeared. Baby Bottle Tooth Decay is a dental pathology of temporary teeth affecting very young children, related to prolonged and frequent use of baby bottle with high carbohydrates content. The important destruction of the temporary teeth hard tissues, and the rapid extension of the lesions carry a high risk of infectious and orthodontic complications with repercussion on the permanent teeth. It is important that pediatricians actively participate to its prevention and early detection.
