ABSTRACT
PURPOSE: To investigate the potential clinical efficacy of Taufon eye drops in silicone hydrogel soft contact lens wearers with nonprogressive myopia. MATERIAL AND METHODS: A total of 90 patients with non-progressive myopia aged from 28 to 45 years were divided in 3 homogeneous groups (30 patients in each). For vision correction silicone hydrogel Air Optix Night & Day ("Ciba Vision") and Pure Vision 2HD ("Bausch & Lomb") contact lenses were used. The average period of contact lens wear was 5.5 +/- 3.3 years. Apart from conventional ophthalmic assessment, all patients underwent a complex lacrimal system examination, which included Schirmer's test and tear film break-up time (TBUT). The Ocular Surface Disease Index (OSDI) was used for dry eye symptoms assessment. The condition of the corneal epithelium was evaluated after 0.2% fluorescein instillation. Group 1 patients received 4% Taufon eye drops, group 2--natural tears ("Alcon"). Group 3 patients did not use any eye drops at all. RESULTS: Baseline Schirmer's test results, TBUT, and OSDI score were similar in all groups (p < 0.05, Mann-Whitney test). Drug therapy was considered effective if Schirmer's test result remained > 10 mm, TBUT--not less than 10 sec, OSDI--not more than 15, there were positive dynamics or at least no negative changes in dry eye signs and symptoms. The patients from group 1 presented no subjective complaits and their corneal and conjunctival changes were less significant than that in other groups (p < 0.05). Regression of dry eye signs at biomicroscopy in this group was confirmed by Schirmer's test results, TBUT, and OSDI. In groups 2 and 3 dry eye sings were more pronounced. CONCLUSION: The study of the 4% Taufon eye drops efficacy for dry eye prevention in silicone hydrogel Air Optix Night & Day and Pure Vision 2HD contact lens wearers with non-progressive myopia showed that the clinical effect was more significant in the treatment group (group 1) as compared to both group 2 (natural tear) and 3 (p < 0.05).
Subject(s)
Contact Lenses, Hydrophilic/adverse effects , Dry Eye Syndromes/drug therapy , Myopia/therapy , Taurine/administration & dosage , Adult , Diagnostic Techniques, Ophthalmological , Drug Monitoring , Dry Eye Syndromes/diagnosis , Dry Eye Syndromes/etiology , Dry Eye Syndromes/physiopathology , Female , Humans , Male , Middle Aged , Ophthalmic Solutions/administration & dosage , Product Surveillance, Postmarketing , Russia , Silicone Gels , Treatment OutcomeSubject(s)
Aminophenols/toxicity , Equipment and Supplies/standards , Food Handling/instrumentation , Naval Medicine/standards , Ships/standards , Water Supply/standards , Aminophenols/analysis , Aminophenols/chemistry , Animals , Corrosion , Food Handling/standards , Humans , Maximum Allowable Concentration , Mice , Rats , Russia , Water Supply/analysisABSTRACT
A method for opening the anterior chamber from under the conjunctival corneal flap was developed. Experimental study of the healing characteristics of the back' profile corneal incision and of the method suggested by the authors, that was used in 12 isolated cadaver eyes, has demonstrated the advantages of the new technique. Clinical trials have confirmed better healing characteristics of the new incision as against the corneal incision. This helped reduce the number of the healing sutures from 7-8 to 4-5. The functional results of treatment (vision acuity, postoperative astigmatism) were also better after anterior chamber opening from under the conjunctival corneal flap.
