ABSTRACT
AIM: To study characteristics of phenotypes of chronic obstructive pulmonary disease (COPD) basing on the findings of modern clinical, functional and roentgenomorphological tests in the course of the disease. MATERIAL AND METHODS: Basing on the results of high performance computed tomography, 64 COPD patients aged 46-75 years (FEV1 51 +/- 24%) were divided into two groups: 53 patients with emphysematous phenotype (group 1) and 11 patients with bronchytic phenotype (group 2). The groups were compared by constitutional, clinical, functional and roentgenological parameters. RESULTS: Group 1 patients had significantly less body mass index, more severe edema by Borg's scale, low FEV1, FEV1/FLC, diffuse lung capacity and lung tissue density compared to group 2. Bronchoectases occurred more frequently in group 1 (33 and 9%, respectively). CONCLUSION: Heterogenous COPD phenotypes differ not only at the stage of chronic respiratory insufficiency but also at all stages of the disease.
Subject(s)
Lung/physiopathology , Pulmonary Disease, Chronic Obstructive/physiopathology , Aged , Female , Forced Expiratory Volume/physiology , Humans , Lung/diagnostic imaging , Lung/pathology , Male , Middle Aged , Phenotype , Pulmonary Disease, Chronic Obstructive/diagnostic imaging , Pulmonary Disease, Chronic Obstructive/pathology , Radiography , SpirometryABSTRACT
Examination covered 213 workers of asbestos technical ware plant. Standard X-ray examination no pulmonary and pleural changes were revealed. External respiration studies demonstrated moderate ventilation disorders in half of the examinees: in hardware workshop workers--restrictive type disorders, in autofriction components workshop workers--obstructive type ones with hyperventilation. Lower diffusing lung capacity in one-third of the workers in one of two autofriction components workshops proves most likely distributive disorders. Moderately increased serum alveolar mucin 3EG5 in 20% of the examinees could be a predictive criterion of slow formation of chisotyle pulmonary fibrosis.
Subject(s)
Asbestosis/blood , Mucins/blood , Adult , Asbestosis/physiopathology , Biomarkers/blood , Disease Progression , Female , Humans , Lung Volume Measurements , Male , Severity of Illness IndexABSTRACT
AIM: To study cardiorespiratory system in adult patients with mucoviscedosis. MATERIAL AND METHODS: External respiration function, echocardiographic and dopplercardiographic evidence were analysed for 22 patients with mucoviscedosis. RESULTS: 66.7% examinees had mixed pulmonary ventilation disorders, 46% were found to have low diffuse capacity of the lungs correlating in degree with ventilatory abnormalities. Dilated right heart and high systolic pressure in the pulmonary artery were registered in 14% patients with marked obstruction. Left ventricular systolic and diastolic defects occurred in 23%. CONCLUSION: Adult patients with mucoviscedosis have mixed disorders of pulmonary ventilation, high pressure in pulmonary circulation and developing pulmonary heart in patients with severe obstruction.
