ABSTRACT
The matrix metalloproteases are the big family of endopeptidases that takes part in degradation of extracellular matrix. The investigation of clinical significance of matrix metalloproteases in heart and vascular pathology can organize the pathogenetic treatment of the patients with heart and vascular diseases.
Subject(s)
Cardiovascular Diseases/diagnosis , Matrix Metalloproteinases/metabolism , Animals , Cardiovascular Diseases/metabolism , HumansABSTRACT
The aim of this study was to estimate the role of matrix metalloproteinases activity (MMP-9, TIMP-1) and gene polymorphism at the patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation. The 60 patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation were investigated with estimation of serum levels of MMP-9, TIMP-1 and mutation of genes of angiotenzinogen 1 Thr 174 Met, angiotenzinogen 2 Met 235 Thr and apolipoprorein C3 C3238 G. In patients with metabolic syndrome in combination with paroxysmal form of atrial fibrillation the significant increase synthesis of MMP-9 level can lead to increase of atrial fibrillation paroxysms because of increase synthesis of collagen tissue in myocard and vessel walls. Also the significant high incidence of angiotenzinogen 2 Met 235 Thr mutation was established.
Subject(s)
Atrial Fibrillation/blood , Matrix Metalloproteinase 9/blood , Metabolic Syndrome/complications , Tissue Inhibitor of Metalloproteinase-1/blood , Adult , Angiotensin I/genetics , Angiotensin II/genetics , Apolipoproteins C/genetics , Atrial Fibrillation/etiology , Atrial Fibrillation/genetics , Case-Control Studies , Humans , Male , Middle Aged , Mutation , Polymorphism, GeneticABSTRACT
The aim of the study was to evaluate effectiveness and safety of angiotensin II receptor blockers and inhibitors of angiotensin-converting enzyme (ECE) for protective therapy following medicamentous cardioversion with propafen at a loading dose of 600 mg in patients with paroxysmal atrial fibrillation and arterial hypertension. 101 patients were divided in 2 groups. Group 1 included 75 patients who received ACE inhibitor lisinopril (10 mg BID) after recovery of sinus rhythm by propanorm. 26 patients of group 2 were treated with angiotensin II receptor blocker candesartan (8 mg daily). Combined treatment with angiotensin II receptor blocker and propafenone leads to cardioversion faster than therapy with ACR inhibitor. It is concluded that alternative approach to the maintenance of sinus rhythm using angiotensin II receptor blockers has advantages over traditional anti-arrhythmic therapy; it is well tolerated by the patients and produced no serious side effects.
Subject(s)
Angiotensin II Type 1 Receptor Blockers/administration & dosage , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Anti-Arrhythmia Agents/administration & dosage , Atrial Fibrillation/prevention & control , Hypertension/drug therapy , Propafenone/administration & dosage , Atrial Fibrillation/etiology , Atrial Fibrillation/physiopathology , Benzimidazoles/administration & dosage , Biphenyl Compounds , Blood Pressure/drug effects , Dose-Response Relationship, Drug , Drug Therapy, Combination , Female , Follow-Up Studies , Heart Rate/drug effects , Humans , Hypertension/complications , Hypertension/physiopathology , Lisinopril/administration & dosage , Male , Middle Aged , Tetrazoles/administration & dosage , Treatment OutcomeABSTRACT
The effect of pathogenetic therapy in the normalization of homeostasis disturbances in monkeys has been shown under experimental conditions. Data on the possibility of using hemosorption in the treatment of severe forms of glanders are presented. The conclusion on the necessity of using complex treatment for the effective therapy of glanders in humans has been made.
Subject(s)
Burkholderia Infections/therapy , Glanders/therapy , Monkey Diseases/therapy , Papio , Acute Disease , Animals , Biomarkers/blood , Burkholderia Infections/blood , Burkholderia Infections/etiology , Burkholderia Infections/immunology , Cell Migration Inhibition , Combined Modality Therapy , Disease Models, Animal , Glanders/blood , Glanders/etiology , Glanders/immunology , Hemoperfusion/instrumentation , Hemoperfusion/methods , Male , Monkey Diseases/blood , Monkey Diseases/etiology , Monkey Diseases/immunologyABSTRACT
Some aspects of homeostasis impairment in monkeys infected with Pseudomonas mallei were investigated. The levels of the hormonal shifts, complement components, beta 2-microglobulin and prostaglandins evident of the infection severity were estimated. The pathomorphological profiles of various forms of malleus in the primates were studied.
