[Risk factors and clinical features of the course of recurrent acute otitis media in children]. / Faktory riska i klinicheskie osobennosti techeniya retsidiviruyushchego srednego otita u detei.

This article discusses the problem of recurrent acute otitis media (RAOM) in children. OBJECTIVE: To study the risk factors and the clinical course of RAOM in children. MATERIAL AND METHODS: 148 children (81 boys and 67 girls) from 1 to 14 years old were examined with a diagnosis of recurrent otitis media. The work was carried out in the ENT departments of Pediatric Clinical Hospital No. 13 named after N.F. Filatov, Pediatric Clinical Hospital named after Z.A. Bashlyaeva. The average age of the children was 4.1±1.5 years.All children underwent a clinical study, a laboratory study on the content of the main metabolite of vitamin D - 25(OH)D3 (25-hydroxyvitamin D, or calcidiol) in blood serum. RESULTS: Our clinical examination of children with RAOM allows us to identify the main risk factors for this pathology. Thus, the most significant risk factors for the development of RAOM in children included in the study were: early visits by children to preschool institutions (50.6%), allergic history (39.1%), pathology during pregnancy (28.3%), mixed (38.5%) or artificial (27.7%) feeding in the first year of life, frequent upper respiratory tract diseases (41.2%), burdened heredity in close relatives according to RAOM (33.7%), smoking in the family of one of the parents (65.5%) presence in the family of one more child (34.4%). CONCLUSION: It was shown that the absolute number of children (96%) with RAOM is characterized by a reduced level of 25(OH) vitamin D in the blood serum, which can increase the likelihood of developing episodes of acute otitis media in children and requires therapeutic correction.

[Use of laser therapy in inflammatory diseases of the paranasal sinuses]. / Primenenie lazernoi terapii pri vospalitel'nykh zabolevaniiakh okolonosovykh pazukh.

105 patients with acute and chronic inflammation of the paranasal sinuses were exposed to the radiation of the semiconductor laser Uzor using gallium arsenide. The treatment combined antiinflammatory drugs with vasoconstrictive nasal drops, maxillary puncture and laser radiation. Intolerance to laser effects was registered in 3 patients. The course of treatment included 5-6 sessions in acute sinusitis and 10 sessions in chronic sinusitis. Laser therapy was found effective as it reduced the time of treatment by 1-2 days.

[The effect of isoprenaline on the aggregation and adhesive properties of circulating rat neutrophils]. / Vliianie izoprenalina na agregatsionnye i adgezivnye svoistva tsirkuliruiushchikh neitrofilov krys.t

It is well known that isoprenaline (1-3-4-dihydroxy-phenyl-isopropyl-aminoethanol) (IP) induce necrosis in myocardium of laboratory animals, which is similar to pathomorphological development of clinical myocardial infarction. This process is accompanied by peripheral blood leukocytes. The IP-inductor effects on arachidonate-dependent aggregation and endothelial adhesion of peripheral blood neutrophils (PN) were studied in this paper. The enhancement of PN aggregational properties within 2-4 hours after intravenous IP-injection to rats was demonstrated. Using the method of vital microscopy it was shown that intravenous IP-injection to rats or IP-application on rat mesentery lead to an increase of leukocyte's marginal pool on the endothelium of mesenteric venules. However, it was noted that the change of cell functional properties is not due to the direct influence of IP on PN. The pathogenetic mechanisms of IP-induced cardiomyopathy in rats were discussed.

[Functional activity of polymorphonuclear leukocytes in isoprenaline-induced cardiomyopathy in rats]. / Funktsional'naia aktivnost' polimorfnoiadernykh leikotsitov krovi pri izoprenalinovoi kardiomiopatii krys.

The article studies the dynamics of changes of the parameters of the functional activity using chemiluminescent and turbidimetric methods as well as blood plasma myocardium and liver homogenates in isoprenaline cardiomyopathy in rats. Mechanisms of pathogenesis of isoprenaline-induced cardiomyopathy in rats is being discussed.

[Effects of low-intensity laser irradiation on the functional activity of leukocytes and blood antioxidant system in acute myocardial infarction]. / Vliianie nizkointensivnogo lazernogo izlucheniia na funktsional'nuiu aktivnost' leikotsitov i antioksidantnuiu sistemu plazmy krovi pri ostrom infarkte miokarda.

Activation of lipid peroxidation and inadequate antioxidant activity essentially contribute to the pathogenesis of acute myocardial infarction, this fact dictating the necessity of correcting these processes. High efficacy of of He-Ne laser therapy was demonstrated in the treatment of 92 patients with myocardial infarction in the acute and subacute periods. This treatment modality corrected lipid peroxidation parameters, which fact manifested by reduction of leukocytic functional activity and elevation of blood plasma antioxidant characteristics.

[Effect of phenothiazines on the viscosity and electrical stability of model phospholipid membranes]. / Vliianie fenotiazinov na viazkost' i élektricheskui stabil'nost' model'nykh fosfolipidnykh membran.

The effect of five phenothiazine derivatives on the viscosity of model phospholipid membranes (by eximerization of pyrene) and on their electrical stability has been studied All the phenothiazines tested (chlorpromazine, propazine, triftazin and nonachlazine), except for chloracyzine, considerably increase the viscosity of phospholipid liposome bilayer at a concentration of 10(-5)-10(-4) M. Phenothiazines have been also shown to decrease liposome break-down potential even at a concentration of 10(-7) M. No correlation between the magnitude of break-down potential and changes in liposome membrane viscosity has been revealed.