1.
Chem Commun (Camb)
; 57(99): 13598-13601, 2021 Dec 14.
Article
in English
| MEDLINE
| ID: mdl-34853840
ABSTRACT
Herein, we report highly diastereoselective arylative cyclization of enone-tethered cyclohexadienones via Rh(III)-catalyzed C-H activation of N-methoxybenzamides. This reaction proceeds through the formation of a five-membered rhodacycle followed by bis-Michael cascade annulation to access functionalized bicyclic scaffolds with four contiguous stereocenters with a broad substrate scope. These products have excellent functional handles, allowing further synthetic transformation to increase the structural complexity. Furthermore, mechanistic studies of arylative cyclization and a gram-scale experiment are also presented.