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Transplant Proc ; 55(6): 1449-1450, 2023.
Article in English | MEDLINE | ID: mdl-37516626

ABSTRACT

Patients who have undergone organ transplantation are immunosuppressed hosts, leaving them at a higher risk of infections. SARS-COV-2 has been shown to affect heart-transplanted patients. In this case report, we present the case of a 14-year-old heart transplant recipient who developed signs and symptoms of heart failure, along with fatigue, after a COVID-19 infection. An endomyocardial biopsy was performed to diagnose rejection and to evaluate whether this was myocarditis due to SARS-COV-2. The biopsy showed intense acute cellular rejection (3R) and antibody rejection PAMR1 H+ but was negative for the SARS-CoV-2 virus. The patient received organ rejection therapy with high-dose methylprednisolone and human immunoglobulin. After treatment, her heart function recovered, with biopsy investigations showing a lower level of cellular rejection (1R).


Subject(s)
COVID-19 , Heart Transplantation , Myocarditis , Humans , Adolescent , Female , Myocarditis/diagnosis , Myocarditis/pathology , Graft Rejection , SARS-CoV-2 , Heart Transplantation/adverse effects , Biopsy , COVID-19 Testing
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