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Bioorg Med Chem Lett
; 24(18): 4598-4602, 2014 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-25149506
ABSTRACT
The synthesis and pharmacological data of some new and potent hydrophilic 5-HT4 receptor antagonists are described. Propanediol derivative 25 was identified as a potent antagonist with low affinity for the hERG potassium channel and promising pharmacokinetics.