ABSTRACT
Leprosy has been a challenge in different areas of medicine; in underdeveloped countries it remains a public health problem, in which the social and economic problems facilitate the disease persistence. The diagnosis and consequently the treatment are delayed due to the clinical polymorphism of leprosy, which especially at the beginning the manifestations are not as evident, as is the case of diffuse lepromatous leprosy. This favors the disabilities and the development of the reaction episodes. Fortunately, reaction episodes have decreased with the use of multidrug therapy, and better control of the type 2 reactions has been managed with the use of thalidomide, as in Lucio's phenomenon.
Subject(s)
Leprostatic Agents/administration & dosage , Leprosy, Lepromatous/drug therapy , Leprosy, Lepromatous/pathology , Mycobacterium leprae/drug effects , Skin Physiological Phenomena/drug effects , Skin Ulcer/pathology , Biopsy, Needle , Disease Progression , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Immunohistochemistry , Leprosy, Lepromatous/complications , Male , Risk Assessment , Severity of Illness Index , Skin Ulcer/drug therapy , Skin Ulcer/etiology , Thalidomide/administration & dosage , Thalidomide/adverse effects , Treatment OutcomeABSTRACT
Leprosy has been a challenge in different areas of medicine; in underdeveloped countries it remains a public health problem, in which the social and economic problems facilitate the disease persistence. The diagnosis and consequently the treatment are delayed due to the clinical polymorphism of leprosy, which especially at the beginning the manifestations are not as evident, as is the case of diffuse lepromatous leprosy. This favors the disabilities and the development of the reaction episodes. Fortunately, reaction episodes have decreased with the use of multidrug therapy, and better control of the type 2 reactions has been managed with the use of thalidomide, as in Lucio's phenomenon.
Subject(s)
Humans , Male , Female , Skin Physiological Phenomena/drug effects , Skin Ulcer/pathology , Leprosy, Lepromatous/drug therapy , Leprostatic Agents/administration & dosage , Skin Ulcer/therapy , Mycobacterium leprae/drug effectsABSTRACT
We present a severe case of disseminated phaeohyphomycosis due to Veronaea botryosa. A 32-year-old female, native from Cuautla, Morelos, Mexico, presented a chronic dermatosis which started 10 years earlier with multiple exophytic, multilobulated, soft, and pedunculated or sessile neoformations of diverse sizes from 2 to 10 cm in diameter, which became verrucose and increased in size. The patient was immunocompetent, and no hereditary or familiar precedents of importance were known. No treatment was given, and the dermatosis remained relatively stable until the patient became pregnant in 2001 and 2003. The infection then exacerbated and worsened, leading to dissemination to the extremities, trunk, and face. The initial diagnosis was chromoblastomycosis which was treated with terbinafine and itraconazole but without visible improvement. Histopathology revealed pigmented, irregular, unbranched, and septate hyphae. Veronaea botryosa was isolated (CBS 127264 = JX566723), and its identity was confirmed by sequencing the internal transcribed spacer (ITS) rDNA. Therapy with posaconazole (800 mg/day) was started showing a gradual improvement of lesions with a reduction in size and flattening of the eruptions.
Subject(s)
Ascomycota/isolation & purification , Phaeohyphomycosis/diagnosis , Phaeohyphomycosis/pathology , Adult , Antifungal Agents/therapeutic use , DNA, Fungal/chemistry , DNA, Fungal/genetics , DNA, Ribosomal Spacer/chemistry , DNA, Ribosomal Spacer/genetics , Female , Histocytochemistry , Humans , Mexico , Phaeohyphomycosis/drug therapy , Phaeohyphomycosis/microbiology , Pregnancy , Sequence Analysis, DNA , Skin/pathology , Treatment Outcome , Triazoles/therapeutic useSubject(s)
Amyloidosis/etiology , Multiple Myeloma/diagnosis , Aged , Anemia/complications , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Goiter/complications , Humans , Male , Multiple Myeloma/complications , Multiple Myeloma/drug therapy , Ocular Motility Disorders/complications , Renal Insufficiency/complicationsABSTRACT
La hiperqueratosis acral focal se caracteriza por el mismo aspecto clínico que la acroqueratoelastoidosis, pero sin anormalidades en las fibras elásticas. Presentamos el caso de una mujer con dermatosis localizada en palmas, plantas y dorso de articulaciones metacarpofalángicas, de 10 años de evolución, constituida por múltiples pápulas poligonales e hiperhidrosis asociadas, clínicamente compatibles con acroqueratoelastoidosis. Tenía el antecedente de enfermedad en el padre. Además, la paciente presentaba queratolisis punteada palmoplantar. Además, la paciente presentaba queratolisis punteada palmoplantar. El estudio histopatológico descartó elastorrexis y la queratolisis punteada se corroboró por el aspecto clínico y la presencia de elementos cocoides en la capa córnea, evidentes con tinción de PAS. En nuestra opinión, la hiperqueratosis acral focal no constituye una entidad independiente de la acroqueratoelastoidosis
Focal acral hyperkeratosis is characterized by the same clinical appearance as acrokeratoelastoidosis, but without abnormalities in the elastic fibers. We present the case of a woman with a 10-year case of dermatosis localized on the palms, soles and dorsum of the metacarpophalangeal joints, consisting of multiple polygonal papules and associated hyperhydrosis, clinically compatible with acrokeratoelastoidosis. Her father had a history of the disease. In addition, the patient presented with palmoplantar pitted keratolysis. The histopathological study ruled out elastorrhexis, and the pitted keratolysis was corroborated by the clinical appearance and the presence of coccoid elements in the stratum corneum, evident with a PAS stain. In our opinion, the focal acral hyperkeratosis is not a separate entity from the acrokeratoelastoidosis
Subject(s)
Adolescent , Female , Humans , Keratoderma, Palmoplantar/diagnosis , Keratoderma, Palmoplantar/therapy , Hyperhidrosis/complications , Hyperhidrosis/diagnosis , Erythromycin/therapeutic use , Hyperhidrosis/etiology , Hyperhidrosis/therapy , Micrococcus/cytology , Micrococcus/pathogenicity , Papilloma/complications , Papilloma/diagnosis , BiopsyABSTRACT
Focal acral hyperkeratosis is characterized by the same clinical appearance as acrokeratoelastoidosis, but without abnormalities in the elastic fibers. We present the case of a woman with a 10-year case of dermatosis localized on the palms, soles and dorsum of the metacarpophalangeal joints, consisting of multiple polygonal papules and associated hyperhydrosis, clinically compatible with acrokeratoelastoidosis. Her father had a history of the disease. In addition, the patient presented with palmoplantar pitted keratolysis. The histopathological study ruled out elastorrhexis, and the pitted keratolysis was corroborated by the clinical appearance and the presence of coccoid elements in the stratum corneum, evident with a PAS stain. In our opinion, the focal acral hyperkeratosis is not a separate entity from the acrokeratoelastoidosis.
Subject(s)
Keratoderma, Palmoplantar/pathology , Adolescent , Female , Humans , Keratoderma, Palmoplantar/complicationsABSTRACT
Se presenta un caso de micosis fungoides en fase tumoral que ha respondido favorablemente al manajo con cobalto luego de 15 sesiones con dosis fraccionadas de 200 rads diarios. Posteriormente, se ha manejado con puvaterapia, obteniendo excelentes resultados hasta el momento
Subject(s)
Humans , Female , Adult , Cobalt , Cobalt/therapeutic use , Methoxsalen , Methoxsalen/therapeutic use , Mycosis Fungoides/drug therapy , Mycosis Fungoides/pathology , PUVA Therapy/statistics & numerical data , Radiotherapy DosageABSTRACT
Mujer de 57 años, tratada quirúrgicamente a causa de un tumor triquilemal proliferante en la piel cabelluda, cuya evolución era de un año. El tumor triquilema proliferante es poco frecuente y representa el 0.1 por ciento de los tumores cutáneos benignos. Se hace una breve revisión acerca del tema
Subject(s)
Humans , Female , Middle Aged , Carcinoma/surgery , Scalp/surgery , Skin Neoplasms/surgery , Carcinoma/pathology , Scalp/pathology , Skin Neoplasms/pathologyABSTRACT
Se comunican cinco casos de nevo lipomatoso de Hoffmann y Zurhelle. Todos en pacientes del sexo masculino. Tres con localización en región glútea; uno en región lumbar y otro en región dorso lumbar. En los casos 1 y 2 se extirpó la lesión y se hizo colgaje de Limberg; en el caso 4 se realizó una extirpación en dos tiempos. Los casos 3 y 5 no fueron tratados. Los resultados cosméticos y funcionales son muy buenos.
Subject(s)
Humans , Male , Adolescent , Adult , Middle Aged , Adipose Tissue , Buttocks/pathology , Lumbosacral Region/pathology , Mexico , Nevus/diagnosis , Skin Neoplasms/diagnosisABSTRACT
Se presenta y comenta un caso de neurilemoma en una de sus topografías habituales: cavidad oral. Se trata de una mujer de 23 años de edad, con evolución de 12 años. Asintómatico. El diagnóstico fue histológico y el tratamiento la extirpación quirúrgica.
Subject(s)
Humans , Female , Adult , Neurilemmoma/pathology , Tongue Neoplasms/pathology , MexicoABSTRACT
Comunicamos un caso excepcional de hidradenoma nodular múltiple en una mujer de 55 años de edad. El diagnóstico fue establecido histológicamente y el tratamiento fue extirpación quirúrgica.
