ABSTRACT
To evaluate aerobic capacity, strength and other physiological, nutritional, and psychological variables which may influence the performance of transgender women (TW) athletes and compare them to cisgender women (CW) and cisgender men (CM) athletes, as well as changes in TW performance over the course of a year. Prospective cohort study including three groups: TW, CW and CM volleyball athletes. Subjects will be comprehensively assessed at two different moments: baseline and after 6-12 months of adequate hormonal therapy. Evaluation will comprise clinical, medical, nutritional and psychological interviews, incremental treadmill cardiopulmonary exercise testing, hand grip strength test, vertical jump test, analysis of sleep quality (Pittsburgh Sleep Quality Index), hormonal profile, echocardiogram, analysis of resting energy expenditure, assessment of bone mass and body composition through dual-energy X-ray absorptiometry scans, and untargeted metabolomic analysis. CW and CM matched by age, body mass index and level of physical activity will undergo a similar evaluation. The assessment of the strength, aerobic capacity, haematological, nutritional and psychological status of TW using gold-standard tests will contribute to understanding the impact of oestrogen therapy on the exercise performance of these athletes and how they compare with CW and CM.
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE: Plinia edulis (Vell.) Sobral (Myrtaceae) is native and endemic to the Brazilian Atlantic Rainforest. Popularly known as "cambucá", it has been used in folk medicine for the treatment of stomach disorders, diabetes, bronchitis, inflammation and as tonic. Although there are numerous records concerning its popular use as analgesic and anti-inflammatory, scientific information regarding these pharmacological activities is limited. Therefore, the aim of this study was to characterize the anti-inflammatory and antinociceptive activity of P. edulis leaf infusion (AEPe) in mice. MATERIALS AND METHODS: The acetic acid-induced writhing response and mechanical nociceptive paw tests were used to evaluate the antinociceptive activity. Carrageenan-induced paw edema and lipopolysaccharide-induced peritonitis were used to investigate the anti-inflammatory activity. The substances in AEPe were identified by HPLC-MS analysis. RESULTS: At the test doses 30-300mg/kg p.o., AEPe has clearly exhibited anti-inflammatory effects, reducing carrageenan-induced paw edema and inhibiting leukocyte recruitment into the peritoneal cavity. The infusion has shown significant antinociceptive activity in both models of nociception. Gallic acid, myricitrin, guaijaverin, quercitrin, quercetin, corosolic acid, maslinic acid, oleanolic acid and ursolic acid were identified in AEPe. CONCLUSION: P. edulis infusion presented antinociceptive and anti-inflammatory activities in all experiments realized in this study, which could be related to the presence of triterpenoids and flavonoids. These results provide scientific support for the traditional use of this species in the management of pain and inflammation.
Subject(s)
Analgesics/pharmacology , Anti-Inflammatory Agents/pharmacology , Edema/prevention & control , Myrtaceae/chemistry , Nociception/drug effects , Nociceptive Pain/prevention & control , Peritonitis/prevention & control , Plant Extracts/pharmacology , Plant Leaves/chemistry , Acetic Acid , Analgesics/isolation & purification , Animals , Anti-Inflammatory Agents/isolation & purification , Behavior, Animal/drug effects , Carrageenan , Chemotaxis, Leukocyte/drug effects , Chromatography, High Pressure Liquid , Disease Models, Animal , Dose-Response Relationship, Drug , Edema/chemically induced , Edema/immunology , Lipopolysaccharides , Male , Mice , Nociceptive Pain/chemically induced , Nociceptive Pain/physiopathology , Nociceptive Pain/psychology , Peritonitis/chemically induced , Peritonitis/immunology , Phytochemicals/isolation & purification , Phytochemicals/pharmacology , Phytotherapy , Plant Extracts/isolation & purification , Plants, Medicinal , Spectrometry, Mass, Electrospray Ionization , Time FactorsABSTRACT
In Argentina more than 7,000 people die each year due to traffic injuries. It is an endemic disease, a serious public health problem. There are evidence-based recommendations about how children should ride safety in cars; children through 8 years or 4 feet 9 inches cannot be fastened by the seat belt so they should ride in a child restraint system. These devices significantly reduce the chances of suffering serious injuries and fatalities. Although in our country the use of car safety seats is not yet legislated nor compulsory, pediatricians should recommend parents how and why to use them.
Subject(s)
Child Restraint Systems , Child , Child, Preschool , Health Knowledge, Attitudes, Practice , Humans , Infant , Infant, Newborn , PhysiciansABSTRACT
En la Argentina mueren más de 7000 personas por año debido a lesiones de tránsito. Es una endemia y un serio problema de salud pública. Existen recomendaciones basadas en la evidencia sobre cómo deben viajar los niños en los automóviles; los menores de 8 años o de 150 cm de altura no pueden ser sujetados por el cinturón de seguridad y deben viajar en un sistema de retención infantil. Estos dispositivos disminuyen significativamente las probabilidades de sufrir lesiones y muerte en una colisión. Si bien en nuestro país aún no está legislada la obligatoriedad de su uso, los pediatras deben recomendar a los padres cómo y por qué utilizarlos.
In Argentina more than 7,000 people die each year due to traffic injuries. It is an endemic disease, a serious public health problem. There are evidence-based recommendations about how children should ride safety in cars; children through 8 years or 4 feet 9 inches cannot be fastened by the seat belt so they should ride in a child restraint system. These devices significantly reduce the chances of suffering serious injuries and fatalities. Although in our country the use of car safety seats is not yet legislated nor compulsory, pediatricians should recommend parents how and why to use them.
Subject(s)
Child , Child, Preschool , Humans , Infant , Infant, Newborn , Child Restraint Systems , Health Knowledge, Attitudes, Practice , PhysiciansABSTRACT
En la Argentina mueren más de 7000 personas por año debido a lesiones de tránsito. Es una endemia y un serio problema de salud pública. Existen recomendaciones basadas en la evidencia sobre cómo deben viajar los niños en los automóviles; los menores de 8 años o de 150 cm de altura no pueden ser sujetados por el cinturón de seguridad y deben viajar en un sistema de retención infantil. Estos dispositivos disminuyen significativamente las probabilidades de sufrir lesiones y muerte en una colisión. Si bien en nuestro país aún no está legislada la obligatoriedad de su uso, los pediatras deben recomendar a los padres cómo y por qué utilizarlos.(AU)
In Argentina more than 7,000 people die each year due to traffic injuries. It is an endemic disease, a serious public health problem. There are evidence-based recommendations about how children should ride safety in cars; children through 8 years or 4 feet 9 inches cannot be fastened by the seat belt so they should ride in a child restraint system. These devices significantly reduce the chances of suffering serious injuries and fatalities. Although in our country the use of car safety seats is not yet legislated nor compulsory, pediatricians should recommend parents how and why to use them.(AU)
Subject(s)
Child , Child, Preschool , Humans , Infant , Infant, Newborn , Child Restraint Systems , Health Knowledge, Attitudes, Practice , PhysiciansABSTRACT
In Argentina more than 7,000 people die each year due to traffic injuries. It is an endemic disease, a serious public health problem. There are evidence-based recommendations about how children should ride safety in cars; children through 8 years or 4 feet 9 inches cannot be fastened by the seat belt so they should ride in a child restraint system. These devices significantly reduce the chances of suffering serious injuries and fatalities. Although in our country the use of car safety seats is not yet legislated nor compulsory, pediatricians should recommend parents how and why to use them.
Subject(s)
Child Restraint Systems , Child , Child, Preschool , Health Knowledge, Attitudes, Practice , Humans , Infant , Infant, Newborn , PhysiciansABSTRACT
The reactive system La(2)O(3)(s)-Cl(2)(g) was studied in the temperature range 260-950 °C. The reaction course was followed by thermogravimetry, and the solids involved were characterized by X-ray diffraction, scanning electron microscopy, and energy dispersive spectroscopy. The results showed that the reaction leads to the formation of solid LaOCl, and for temperatures above 850 °C, the lanthanum oxychloride is chlorinated, producing LaCl(3)(l). The formation of the oxychloride progresses through a nucleation and growth mechanism, and the kinetic analysis showed that at temperatures below 325 °C the system is under chemical control. The influence of diffusive processes on the kinetics of production of LaOCl was evaluated by studying the effect of the reactive gas flow rate, the mass of the sample, and the chlorine diffusion through the boundary layer surrounding the solid sample. The conversion curves were analyzed and fitted according to the Johnson-Mehl-Avrami description, and the reaction order with respect to the chlorine partial pressure was obtained by varying this partial pressure between 10 and 70 kPa. The rate equation was obtained, which includes the influence of the temperature, chlorine partial pressure, and reaction degree.
ABSTRACT
Existen dos amebas, morfológicamente idénticas, cuyas diferencias determinanque una de ellas, Entamoeba histolytica, pueda ser patógena. La otra, Entamoeba dispar, es inocua.Surgió la presunción de que casos tratados como amebiasis, no lo fueran. Objetivo. Identificar E. histolytica en niños con disenterías supuestamente amebianas. Métodos. Estudio transversal y observacional realizado en Santa Fe, entre marzo de 2005 y noviembre de 2007. En niños de 2 meses a 15 años con disentería y exámenes directos con E. histolytica/dispar, se realizó ELISA para detectar la adhesina de E. histolytica (adhesina Eh) en heces.Se efectuaron coloraciones para amebas, coprocultivos y se registraron datos clínicos.Resultados. De 75 casos estudiados, 35 fueron varones y 40 mujeres, con edad (mediana) de 3 años. Todos presentaron diarreas agudas con leucocitos;73 por ciento en sangre visible microcópicamente y 27 por ciento en el estudio microscópico. Tuvieron adhesina Eh positiva, 21. En 3 de ellos se detectaron trofozoítos hematófagos.Se realizaron 15 coprocultivos, en 5 desarrolló S. flexneri de tipo S2. Otros parásitos: 6 (Blastocystis homini 5).Tuvieron adhesina Eh negativa, 54. El 19 por ciento de las coloraciones demostró E. dispar.A 44 se les realizaron coprocultivos; desarrollaron bacterias invasivas 12 casos: S. flexneri de tipo S2 (13), Shigella sp (1), C. jejuni (5), otros (3). Otros parásitos: 12 (Blastocystis hominis 9).Conclusión. En este grupo de niños con disenterías amebianas, en la mitad de los casos seidentificaron bacterias invasivas y sólo en el 28 por ciento se detectó E. histolytica en heces, con lo cual cabría esperar una prevalencia de 18-38 por ciento de casos positivos en la población [IC 95 por ciento (0,179; 0,381)].
Subject(s)
Humans , Male , Adolescent , Infant , Child, Preschool , Child , Female , Amebiasis , Dysentery, Bacillary , Dysentery, Amebic/diagnosis , Entamoeba histolytica , Intestinal Diseases, Parasitic , Cross-Sectional Studies , Diagnosis, Differential , Epidemiology, Descriptive , Observational Studies as Topic , Data Interpretation, StatisticalABSTRACT
Existen dos amebas, morfológicamente idénticas, cuyas diferencias determinanque una de ellas, Entamoeba histolytica, pueda ser patógena. La otra, Entamoeba dispar, es inocua.Surgió la presunción de que casos tratados como amebiasis, no lo fueran. Objetivo. Identificar E. histolytica en niños con disenterías supuestamente amebianas. Métodos. Estudio transversal y observacional realizado en Santa Fe, entre marzo de 2005 y noviembre de 2007. En niños de 2 meses a 15 años con disentería y exámenes directos con E. histolytica/dispar, se realizó ELISA para detectar la adhesina de E. histolytica (adhesina Eh) en heces.Se efectuaron coloraciones para amebas, coprocultivos y se registraron datos clínicos.Resultados. De 75 casos estudiados, 35 fueron varones y 40 mujeres, con edad (mediana) de 3 años. Todos presentaron diarreas agudas con leucocitos;73 por ciento en sangre visible microcópicamente y 27 por ciento en el estudio microscópico. Tuvieron adhesina Eh positiva, 21. En 3 de ellos se detectaron trofozoítos hematófagos.Se realizaron 15 coprocultivos, en 5 desarrolló S. flexneri de tipo S2. Otros parásitos: 6 (Blastocystis homini 5).Tuvieron adhesina Eh negativa, 54. El 19 por ciento de las coloraciones demostró E. dispar.A 44 se les realizaron coprocultivos; desarrollaron bacterias invasivas 12 casos: S. flexneri de tipo S2 (13), Shigella sp (1), C. jejuni (5), otros (3). Otros parásitos: 12 (Blastocystis hominis 9).Conclusión. En este grupo de niños con disenterías amebianas, en la mitad de los casos seidentificaron bacterias invasivas y sólo en el 28 por ciento se detectó E. histolytica en heces, con lo cual cabría esperar una prevalencia de 18-38 por ciento de casos positivos en la población [IC 95 por ciento (0,179; 0,381)].(AU)
Subject(s)
Humans , Male , Adolescent , Infant , Child, Preschool , Child , Female , Dysentery, Amebic/diagnosis , Entamoeba histolytica , Amebiasis , Intestinal Diseases, Parasitic , Dysentery, Bacillary , Observational Studies as Topic , Cross-Sectional Studies , Epidemiology, Descriptive , Diagnosis, Differential , Data Interpretation, StatisticalABSTRACT
INTRODUCTION: There are morphologically identical amebaes, but with differences that can distinguish them; one as pathogenic: Entamoeba histolytica, and the other: Entamoeba dispar, as inoffensive. That brought the new hypothesis that many of the cases treated as amebiasis, weren't so. OBJECTIVE: To identify E. hystolitica in patients with dysentery, supposed to be caused by amebae. METHODS: Transversal and observational study performed between March 2005 and November 2007 in the city of Santa Fe, Argentina. Stools from children aged 2 months to 15 years-old with dysentery and direct exams with E. hystolitica/ dispar, were studied with ELISA to detect the adhesin of E. histolytica (adhesin Eh). Permanent stains for amebae were done as well as stool cultures. Clinical data were charted. RESULTS: 75 children were studied; 35 were male and 40, female, with a median age of 3 years-old. All of them presented diarrhea with leucocyte, 73% macroscopic blood on stool and 27% detectable on the microscope. Elisa Eh was positive in 21; 3 cases had hematophagous trophozoites. In 15 stool cultures were found: S. flexneri S2 type in 5 cases. Other parasites: 6 (Blastocystis homini 5). In 54 adhesin Eh was negative, 19% of the coulouring detected E. dispar. From 44 stool cultures: S. flexneri S2 type was detected in 13, Shigella sp in 1, C jejuni 5, other: 3. Other parasites: 12 (Blastocystis homini 9). CONCLUSION: In this group of children with "amebic dysentery", half of them developed invasive bacteriae and only 28% had E. histolytica on stools; that means that the prevalence of positive cases in the population could be 18% to 38% [CI 95% (0.179; 0.381)].
Subject(s)
Dysentery, Amebic , Dysentery/epidemiology , Dysentery/parasitology , Adolescent , Argentina/epidemiology , Child , Child, Preschool , Diagnosis, Differential , Dysentery, Amebic/complications , Dysentery, Amebic/diagnosis , Dysentery, Amebic/epidemiology , Enzyme-Linked Immunosorbent Assay , Female , Humans , Infant , Male , PrevalenceABSTRACT
Con el presente estudio tratamos de averiguar la incidencia del Estreptococo beta hemolítico en nuestro medio como causa de Faringoamigdalitis aguda o crónica. A 100 pacientes con este cuadro clínico se les realizó Exudado Faringeo y dosaje de Antiestreptolisinas O. Los resultados encontrados nos dan aproximadamente una incidencia de 20% de casos con Estreptococo beta hemolítico en el Exudado Faringeo. Es la Penicilina el antibiótico adecuado para el tratamiento de la Faringoamigdalitis ya que nuestro estudio lo corrobora una vez más
