Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
1.
BMC Infect Dis ; 13: 2, 2013 Jan 02.
Article in English | MEDLINE | ID: mdl-23282073

ABSTRACT

There are approximately from 1,100 to 1,200 HIV-infected children in a follow-up in Spain. In 2008 an open, multicentral, retrospective and prospective Cohort of the Spanish Paediatric HIV Network (CoRISpe) was founded. The CoRISpe is divided into the node 1 and node 2 representing geographically almost the whole territory of Spain. Since 2008 seventy-five hospitals have been participating in the CoRISpe. All the retrospective data of the HIV-infected children have been kept in the CoRISpe since 1995 and prospective data since 2008. In this article we are going to present the notion of CoRISpe, its role, the structure, how the CoRISpe works and the process how a child is transferred from Paediatric to Adults Units. The main objective of the CoRISpe is to contribute to furthering scientific knowledge on paediatric HIV infection by providing demographic, sociopsychological, clinical and laboratory data from HIV-infected paediatric patients. Its aim is to enable high-quality research studies on HIV-infected children.


Subject(s)
Databases, Factual , Electronic Health Records , HIV Infections/epidemiology , Adult , Biomedical Research , Child , Child, Preschool , Cohort Studies , Female , HIV Infections/transmission , Humans , Infant , Infant, Newborn , Infectious Disease Transmission, Vertical/statistics & numerical data , Male , Spain/epidemiology , Viral Load
2.
Clin Infect Dis ; 38(11): 1605-12, 2004 Jun 01.
Article in English | MEDLINE | ID: mdl-15156450

ABSTRACT

We performed a retrospective observational study of 253 children vertically infected with human immunodeficiency virus (1994-2001) to assess the effectiveness of antiretroviral therapies (ARTs) on survival and surrogate markers at the population level. Children were divided into 3 groups according to the ART protocols used during the follow-up period: calendar period (CP) 1 (1994-1996) received combined therapy with 2 nucleoside reverse transcriptase inhibitors (NRTIs); CP2 (1997-1998) received implementation of highly active ART (HAART) with 3 drugs (NRTIs, protease inhibitors, and non-NRTIs); and CP3 (1999-2001) received extensive HAART. The children in the CP3 group had statistically significant longer survival periods, lower virus load (VL), highest undetectable VL proportion, and highest CD4+ T cell counts. HAART is effective at the population level at decreasing VL, increasing CD4+ T cells, and increasing the survival in a higher percentage of HIV-infected children.


Subject(s)
Antiretroviral Therapy, Highly Active/methods , HIV Infections/drug therapy , HIV Infections/transmission , Infectious Disease Transmission, Vertical , Anti-HIV Agents/administration & dosage , Anti-HIV Agents/therapeutic use , Biomarkers/analysis , CD4 Lymphocyte Count , CD4-Positive T-Lymphocytes/metabolism , Child , Child, Preschool , Cohort Studies , Drug Administration Schedule , Drug Therapy, Combination , HIV Infections/mortality , HIV Reverse Transcriptase/antagonists & inhibitors , HIV Reverse Transcriptase/physiology , Humans , Retrospective Studies , Reverse Transcriptase Inhibitors/administration & dosage , Reverse Transcriptase Inhibitors/therapeutic use , Survival Analysis , Time , Viral Load/trends
3.
AIDS ; 18(2): 247-55, 2004 Jan 23.
Article in English | MEDLINE | ID: mdl-15075542

ABSTRACT

OBJECTIVE: To investigate the effects of salvage therapy with lopinavir-ritonavir on HIV-1 phenotype in heavily antiretroviral experienced HIV-infected children. DESIGN: Twenty antiretroviral experienced HIV-infected children were studied during a mean of time of 16.1 months from initiation of the treatment with lopinavir-ritonavir. METHODS: Besides CD4 T cells, viral load and clinical status, we analyzed 91 serial viral isolates to study the phenotype, and biological clones derived from co-cultivation techniques. RESULTS: We observed an increase in CD4 T cells, a statistically significant decrease in viral load and clinical benefits from 3 months after treatment. Ninety per cent of children had SI/X4 bulk isolates in peripheral blood mononuclear cells at study entry. The viral phenotype changed to non syncitium-inducing (NSI)/R5 in 94% of the children after a mean of 5.7 months (95% confidence interval, 2.1-9.3 months) of salvage therapy. The remaining 10% of children had NSI/R5 isolates at entry and at all follow-up study. Similar results were found at the clonal level. Thus, at study entry in PBMC of three children with bulk syncitium-inducing (SI) phenotype, we recovered 65 biologic clones, 56 being SI and nine NSI. After salvage therapy bulk isolates changed to NSI and of 40 biologic clones recovered only five were SI and the rest were NSI. CONCLUSIONS: Our data suggest that lopinavir-ritonavir salvage therapy led not only to a viral load decrease but also to a phenotypic change. X4 virus appeared to be preferentially suppressed. Shifts in co-receptor usage may thereby contribute to the clinical efficacy of anti-HIV drugs in vertically infected infants.


Subject(s)
HIV Infections/drug therapy , HIV Protease Inhibitors/therapeutic use , HIV-1/physiology , Pyrimidinones/therapeutic use , Ritonavir/therapeutic use , Drug Combinations , Female , HIV Infections/transmission , Humans , Infant , Infectious Disease Transmission, Vertical , Leukocytes, Mononuclear/virology , Lopinavir , Male , Phenotype , Salvage Therapy , T-Lymphocyte Subsets , Viral Load , Virus Replication/drug effects
SELECTION OF CITATIONS
SEARCH DETAIL
...