ABSTRACT
El carcinoma neuroendocrino primario de vejiga es una neoplasia infrecuente que representa el 0,5por ciento de todos los tumores vesicales. La asociación de carcinoma neuroendocrino de vejiga en un paciente con infección por VIH nunca hasta hoy había sido descrita. Presentamos el primer caso clínico español y mundial de esta desconocida y nunca descrita asociación. MATERIAL Y MÉTODOS: Se presenta el caso clínico de una paciente de 46 años con infección por VIH que desarrolló un carcinoma neuroendocrino de vejiga urinaria de evolución fatal. Se describe su clínica de presentación, métodos de diagnóstico utilizados y su tratamiento. La paciente debutó con retención urinaria aguda que rápidamente progresó a la instauración de una uropatía obstructiva alta con deterioro de la función renal. El diagnóstico se efectuó mediante TAC, resección transuretral y estudio histopatológico donde la clave del diagnóstico fue el estudio inmunohistoquímico intensamente positivo para la cromogranina A. El tratamiento adyuvante con quimioterapia le ocasionó una aplasia medular severa, falleciendo por fallo multiórganico a los 26 días de su diagnóstico. A propósito de este caso, se revisa la literatura inglesa en PubMed sobre carcinoma neuroendocrino de vejiga y sobre tumores vesicales en pacientes con infección VIH, no existiendo ningún caso publicado de carcinoma neuroendocrino de vejiga en un paciente con infección por VIH. CONCLUSIONES: El carcinoma neuroendocrino de vejiga es un tumor infrecuente y muy agresivo. Es un tumor que suele presentarse clínicamente en estadios avanzados o metastásicos donde ninguna terapia es eficaz. El tratamiento incluye resección trans-uretral (RTU), cistectomía parcial, cistectomía radical y quimioterapia. El estudio inmunohistoquímico (IHQ) y la tinción con cromogranina A dan la clave para su diagnóstico. Su presentación en pacientes VIH implica muy mal pronóstico. Éste caso es el primer caso mundial publicado de carcinoma neuroendocrino...
The primary neuroendocrine carcinome of the bladder is an infrequent neoplasm which represents 0.5 percent of all vesical tumors. The association of neuroendocrine carcinome of the bladder in a patient with HIV infection has never been described before today. We present the first clinical case in the Spanish-speaking world and worldwide, of this unknown and never written about association. MATERIAL AND METHODS: The clinical case of a 46-yearoldpatient with HIV infection who developed a neuroendocrine carcinoma of the urinary bladder with a fatal evolution, its clinical presentation, the diagnosis methods used and its treatment, are described. The patient started with a severe urinary retention which rapidly progressed to the establishment of a high obstructive uropathy with deterioration in the renal function. The diagnosis was done using TAC, transurethral resection and histopathological study where the key to diagnosis was the intensely positive immunohistochemical study for the chromogranin A. The adjuvant treatment with chemotherapy led to a severe medular aplasia, with the patient dying due to a multi-organ failure, 26 days after her diagnosis. As a result of this case, English literature on the matter in PubMed about neuroendocrine carcinome of the bladder and about vesical tumors in patients with HIV infection was revised, with no published case existing about neuroendocrine carcinome in a patient with HIV. CONCLUSIONS: The neuroendocrine carcinome of the bladder is an infrequent and very aggressive tumor. It is a tumor that tends to be clinically present in advanced or metastasic states, where no therapy is efficient. The treatment includes transurethral resection (TUR), partial cystectomy, radical cystectomy and chemotherapy. The immunohistochemical study (IHC), and the stain with chromogranin A are key for its diagnosis. Its presentation in HIV patients implies a very bad prognosis. This case is the first published case worldwide of neuroendocrine...
Subject(s)
Humans , Female , Middle Aged , Carcinoma, Neuroendocrine/complications , HIV Infections/complications , Urinary Bladder Neoplasms/complications , Fatal OutcomeABSTRACT
We report the case of unilocular cystic renal cell carcinoma and its radiological findings. Cystic renal cell carcinomas are among 3 to 7% of kidney cancers and sometimes are difficult to diagnose, as it happened in this case.
Subject(s)
Carcinoma, Renal Cell/diagnosis , Kidney Neoplasms/diagnosis , Humans , Male , Middle AgedABSTRACT
We report two cases of pulmonary BCG-induced pneumonitis recently diagnosed amongst our patients. The first case is a 81 year old man under BCG bladder instillation treatment because of high grade superficial bladder cancer who developed a severe interstitial granulomatous pneumonitis. The patient was treated with corticosteroids and tuberculostatics with a rapid and complete response. The second patient is a young man who presented only with persistent fever and also had a complete response after treatment.
Subject(s)
Adjuvants, Immunologic/adverse effects , BCG Vaccine/adverse effects , Granuloma/chemically induced , Pneumonia/chemically induced , Adjuvants, Immunologic/administration & dosage , Administration, Intravesical , Aged, 80 and over , BCG Vaccine/administration & dosage , Humans , Male , Middle Aged , Urinary Bladder Neoplasms/drug therapyABSTRACT
UNLABELLED: Differentiating a primary retroperitoneal seminoma from a metastatic testicular tumor with an occult testicular primary or a burned out testicular cancer remains difficult. We present a case of a burned out tumor. The patient had a retroperitoneal seminoma with ultrasonically and pathologically demonstrated abnormalities in both testes, but without evidence of tumor. The patient received chemotherapy and underwent surgery of the residual retroperitoneal mass and bilateral orchiectomy. All surgical specimens were negative for testis cancer. CONCLUSION: Primary extragonadal germ cell tumors in the retroperitoneum are a rare entity. The presence of a retroperitoneal tumor with ultrasonographical abnormalities in testicular evaluation should be considered as a metastases of a burned out testicular cancer, and biopsy is mandatory. Surgical evaluation and orchiectomy should be evaluated in a individual setting.
Subject(s)
Neoplasms, Multiple Primary , Retroperitoneal Neoplasms , Seminoma , Testicular Neoplasms , Adult , Humans , Male , Neoplasms, Multiple Primary/diagnosis , Retroperitoneal Neoplasms/diagnosis , Seminoma/diagnosis , Testicular Neoplasms/diagnosisABSTRACT
We report a case of a man with erythrocytosis secondary to hydronephrosis in a right horseshoe kidney. The patient had an advanced hydronephrosis because of ureteropelvic junction obstruction occupying the right hemiabdomen. Following nephrectomy of the right kidney erythrocyte count returned to normal values. Secondary polyglobulia may be due to increased erythropoietine values and has been related in some patients with renal diseases such as hydronephrosis, but very rarely in association with hydronephrotic horseshoe kidney.
Subject(s)
Hydronephrosis/complications , Kidney/abnormalities , Polycythemia/etiology , Adult , Humans , Hydronephrosis/diagnostic imaging , Hydronephrosis/surgery , Kidney/pathology , Kidney/surgery , Male , Nephrectomy , Platelet Count , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
INTRODUCTION: The ambulatory surgery includes those surgical procedures that require a limited period of post-operative recovery, so that patients will be discharged from hospital on the same day of their surgical operation. OBJECTIVES: This publication aims at both, explaining our Service way of working as an integrated unit of ambulatory surgery, and it also tries to revise the results which have been obtained during our first 5 years working together. METHOD AND MATERIALS: Three hundred and thirty-nine patients, with an average age of 37.5 years (3-84), have been included in this report which sets out the medical record of this patients selection, their pathologies, the different procedures used, the kind of anaesthesia as well as the criterion to discharge them from hospital. RESULTS: Intra-surgical complications have arisen in 4 (1.2%) of our patients, immediate complications in 24 patients (7%) and late ones in 33 (9.7%) of our patients. According to the results of an anonymous inquiry which has been polled systematically to all our patients, 95% of those polled are completely satisfied with this new way of medical attention. CONCLUSIONS: The ambulatory surgery means a slight change in our patients' way of life. It also diminishes hospital costs, morbidity is similar to the one produced in hospitalization and it implies an important challenge for the professionals of this Service.
Subject(s)
Ambulatory Surgical Procedures/statistics & numerical data , Urologic Surgical Procedures/statistics & numerical data , Adolescent , Adult , Aged , Aged, 80 and over , Anesthesia/statistics & numerical data , Child , Child, Preschool , Circumcision, Male/statistics & numerical data , Female , Genital Diseases, Male/surgery , Humans , Intraoperative Complications/epidemiology , Male , Middle Aged , Patient Selection , Postoperative Complications/epidemiology , Retrospective Studies , Spain/epidemiology , Urologic Diseases/surgeryABSTRACT
We have analyzed a set of 27 patients diagnosed of penile cancer who have been treated in our Hospital during the last 17 years (since january 1984 to december 2000). The annual incidence was set in 1.7 patients/100,000 men/year. The average age has been 64 years (range 42-85). Patients delayed medical consulting of their lesions for 15 months (2-120). Histologic analysis found an epidermoid carcinoma in 19 patients, and verrucous carcinoma in 8. The average follow-up has been 48 months (range 2-120). As a conclusion we don't belive necessary prophylactic inguinal lymphadenectomy. Correct followup, for early detection of lymph nodes does not worsen survival and it avoids unnecessary operations with a high rate of morbidity. The prognostic factors in our patients have been the presence of lymph nodes and the degree of local extension. We lack of experience with radiotherapy and chemotherapy.
Subject(s)
Penile Neoplasms/epidemiology , Adult , Aged , Aged, 80 and over , Humans , Male , Middle Aged , Retrospective Studies , SpainABSTRACT
Cases of uterine perforation through to the bladder during the placement of an intrauterine device are rare. There have been only 25 previous reported cases. This type of perforation is no different to any other by an intravesical foreign body. A detailed anamnesis and sonographic examination is usually sufficient to provide a diagnosis. Complications can be diagnosed by an uretrocytoscopy which is also therapeutic in non-complicated cases. If there are associated complications surgery can be necessary. In conclusion, quick detection of any complication, by sonographic detection after placement, assists in the extraction of the foreign body and avoids the appearance of associated complications such as lithiasis.
Subject(s)
Foreign-Body Migration/complications , Intrauterine Devices/adverse effects , Uterine Perforation/etiology , Female , Humans , Middle AgedABSTRACT
The androgen insensitivity syndrome is the most frequent form of masculine psedohermafroditism. The affected patients present female phenotype without sexual ambiguity but with karyotype 46 XY. In this syndrome the frequency of malignización of the testicles increases progressively with the age, because of this, the importance of an earlier diagnosis. We present a case of later diagnosis late of the androgen insensitivity syndrome, that debut with a great inguinal mass.
Subject(s)
Androgen-Insensitivity Syndrome/complications , Testicular Neoplasms/etiology , Adult , Androgen-Insensitivity Syndrome/diagnosis , Female , Groin , Humans , MaleABSTRACT
OBJECTIVE: Evaluation of the effectiveness of the surveillance tumoral by means of computerized protocols. MATERIAL AND METHODOLOGY: We have carried out a retrospective study, taking as example the superficial bladder cancer, where we have compared the execution of the tumoral surveillance of the computerized protocols regarding the conventional ones. RESULTS: It has been demonstrated that the execution percentage and the adjustment to the predetermined terms of the explorations requested by the facultative are superior in the computerized protocols that in the conventional ones. CONCLUSION: The computerization of the tumoral protocols is user-friendly, it improves the execution degree and it saves time, providing bigger effectiveness and scientific rigor.
Subject(s)
Guideline Adherence , Medical Records Systems, Computerized , Records , Urinary Bladder Neoplasms/therapy , Follow-Up Studies , Humans , Population Surveillance , Retrospective StudiesABSTRACT
AIM OF THE STUDY: To describe a simplified technique for nephroureterectomy based on a prior endoscopic disconnection of the ureter or transurethral circumcision of the ureteral orifice. PATIENTS AND METHODS: From November 1993 to December 1997 we treated 16 patients diagnosed with cancer of the renal pelvis of proximal ureter, using this technique. Mean age was 68.8, 15 males and 1 female. RESULTS: There was no operative or postoperative complications. Mean follow up was 17 months and the mean hospital stay was 7.2 days. CONCLUSIONS: We believe that this is an easy technique to learn, that significantly cut down the operating time, reduce postoperative complications and it is adequate for upper tract urothelial cancer treatment.
