Subject(s)
Basal Ganglia Diseases/diagnostic imaging , Basal Ganglia Diseases/pathology , Brain/diagnostic imaging , Brain/pathology , Fragile X Syndrome/complications , Heredodegenerative Disorders, Nervous System/diagnostic imaging , Heredodegenerative Disorders, Nervous System/pathology , Aged , Ataxia/diagnostic imaging , Ataxia/genetics , Ataxia/pathology , Atrophy/diagnostic imaging , Atrophy/genetics , Atrophy/pathology , Basal Ganglia Diseases/genetics , Binding, Competitive/physiology , Brain/physiopathology , Corpus Striatum/diagnostic imaging , Corpus Striatum/pathology , Corpus Striatum/physiopathology , Diagnosis, Differential , Diagnostic Errors/prevention & control , Extrapyramidal Tracts/diagnostic imaging , Extrapyramidal Tracts/pathology , Extrapyramidal Tracts/physiopathology , Heredodegenerative Disorders, Nervous System/genetics , Humans , Magnetic Resonance Imaging , Male , Mesencephalon/diagnostic imaging , Mesencephalon/pathology , Mesencephalon/physiopathology , Middle Aged , Parkinson Disease/diagnosis , Parkinson Disease/physiopathology , Predictive Value of Tests , Radiography , Radioisotopes , Receptors, Dopamine/metabolism , Syndrome , Tomography, Emission-Computed, Single-Photon , Tremor/diagnostic imaging , Tremor/genetics , Tremor/pathologyABSTRACT
OBJECTIVE: To concurrently investigate with magnetic resonance (MR) the brain activation and regional brain atrophy in patients with Huntington disease (HD). METHODS: Nine symptomatic HD patients and 11 healthy subjects underwent an MR study including functional MR acquisition during finger tapping of the right hand and high-resolution T1-weighted images. Functional and structural data were analyzed using Statistical Parametric Mapping 2 software. RESULTS: As compared with control subjects, HD patients showed decreased activation in the left caudate nucleus and medial frontal and anterior cingulate gyri and increased activation in the right supplementary motor area and supramarginal gyrus and left intraparietal sulcus. The pattern of atrophy included thinning of the gray matter (GM) in the insula, inferior frontal gyrus, caudate, lentiform nucleus, and thalamus, bilaterally, in the left middle frontal, middle occipital, and middle temporal gyri, and of periventricular, subinsular, right temporal lobe, and left internal capsule white matter. Only the decreased activation in the caudate nucleus correlated topographically with the caudate GM loss. CONCLUSION: The cortical areas of functional changes do not correspond to those of GM atrophy in patients with HD and are likely to reflect decreased output of the motor basal ganglia-thalamo-cortical circuit and compensatory recruitment of accessory motor pathways.